Results 81 to 90 of about 3,877 (200)

RNA binding protein ZFP36L1 promotes ferroptosis in chronic rhinosinusitis by destabilizing CAMK2A mRNA and impairing mitochondrial quality control

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
This graphical abstract illustrates the novel ZFP36L1–CAMK2A regulatory axis in chronic rhinosinusitis (CRS) pathogenesis: 1. Molecular initiation: In nasal epithelial cells, the RNA‐binding protein ZFP36L1 (upregulated in CRS) directly binds to AU‐rich elements (AREs) in the 3′‐untranslated region (3′‐UTR) of CAMK2A mRNA, promoting its degradation and
Jiayi Xiong, Shihan Zhang, Chunhua Li, Yufeng Ai, Xinru Liu, Yuxiang Liu, Hongbing Liu   +6 more
wiley   +1 more source

mTOR Regulates Cellular Iron Homeostasis through Tristetraprolin [PDF]

Cell Metabolism, 2012
Iron is an essential cofactor with unique redox properties. Iron-regulatory proteins 1 and 2 (IRP1/2) have been established as important regulators of cellular iron homeostasis, but little is known about the role of other pathways in this process. Here we report that the mammalian target of rapamycin (mTOR) regulates iron homeostasis by modulating ...
Bayeva, Marina, Khechaduri, Arineh, Puig, Sergi, Chang, Hsiang-Chun, Patial, Sonika, Blackshear, Perry J., Ardehali, Hossein   +6 more
openaire   +2 more sources

FOXO1 Is a Key Mediator of Glucocorticoid-Induced Expression of Tristetraprolin in MDA-MB-231 Breast Cancer Cells

International Journal of Molecular Sciences, 2022
The mRNA destabilizing factor tristetraprolin (TTP) functions as a tumor suppressor by down-regulating cancer-associated genes. TTP expression is significantly reduced in various cancers, which contributes to cancer processes.
Do Yong Jeon, Soyeon Jeong, Ju Won Lee, Jeonghwan Kim, Jee Hyun Kim, H. Chu, Wonjoon Jeong, B. Lee, B. Ahn, Junil Kim, Seong Hee Choi, Jeong Woo Park   +11 more
semanticscholar   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Diverse immunological roles of liver‐resident immune cells in liver diseases

Precision Medical Sciences, Volume 15, Issue 1, Page 4-17, March 2026.
Based on their origin and functional characteristics, LRICs can be classified into four categories. These cells differ in the focus of their immune functions in liver diseases, yet all exhibit the characteristic of functional bidirectionality.
Zhengyi Fan, Xinqiang Li, Peng Jiang, Dahong Teng, Jinzhen Cai   +4 more
wiley   +1 more source

Tristetraprolin Impairs NF-κB/p65 Nuclear Translocation [PDF]

Journal of Biological Chemistry, 2009
Tristetraprolin (TTP) is a prototypic family member of CCCH-type tandem zinc-finger domain proteins that regulate mRNA destabilization in eukaryotic cells. TTP binds to AU-rich elements (AREs) in the 3'-untranslated region of certain mRNAs, including tumor necrosis factor alpha, granulocyte macrophage colony-stimulating factor, and immediate early ...
Yvonne M, Schichl, Ulrike, Resch, Renate, Hofer-Warbinek, Rainer, de Martin   +3 more
openaire   +2 more sources

MicroRNA-29a Promotes Pancreatic Cancer Growth by Inhibiting Tristetraprolin

Cellular Physiology and Biochemistry, 2015
Background/Aims: The microRNA (miR) 29 family has been studied extensively for its involvement in several diseases, and aberrant expression of its members is associated with tumorigenesis and cancer progression.
Xian-Jun Sun, Bing-Yan Liu, Shuo Yan, Ting-Hui Jiang, Hui-Qin Cheng, Hao-Sheng Jiang, Yan Cao, Ai-Wu Mao   +7 more
doaj   +1 more source

Hydroxychloroquine attenuates double‐stranded RNA‐stimulated hyper‐phosphorylation of tristetraprolin/ZFP36 and AU‐rich mRNA stabilization

Immunology
The human innate immune system recognizes dsRNA as a pathogen‐associated molecular pattern that induces a potent inflammatory response. The primary source of pathogenic dsRNA is cells infected with replicating viruses, but can also be released from ...
E. Hitti, Zeyad Muazzen, Walid Moghrabi, Suhad Al-Yahya, Khalid S A Khabar   +4 more
semanticscholar   +1 more source

Loss of the RNA Binding Protein HuR in Early Murine Limb Mesenchyme Does Not Affect Development but Leads to Impaired Bone Homeostasis in Adulthood

The FASEB Journal, Volume 39, Issue 22, 30 November 2025.
The RNA‐binding protein HuR (Elavl1) is essential for limb development. In germline HuR knockouts, apical ectodermal ridge signaling is lost, though mesenchymal signals persist. Mesenchyme‐specific HuR deletion does not affect embryonic limbs, but adult mutants are affected and exhibit markedly reduced trabecular bone density.
Shijian Fu, Kirsty A. Johnson, Phaedra Winstanley‐Zarach, Ufuk Ersoy, Elena Adlmanninger, Benjamin T. McDermott, Craig Keenan, Aphrodite Vasilaki, Ioannis Kanakis, Peter I. Milner, Rob J. van’t Hof, Dimitris Kontoyiannis, George Bou‐Gharios, David A. Turner, Simon R. Tew   +14 more
wiley   +1 more source

Tristetraprolin and E6-AP: Killing the messenger in cervical cancer [PDF]

Cell Cycle, 2010
Cervical cancer, a human papillomavirus (HPV)-induced malignancy, is the most common gynecological cancer worldwide. Infection of cervical epithelium with highrisk HPV subtypes-16 and -18 followed by HPV integration into the host genome allows for constitutive expression of viral oncoproteins.
Sandhya, Sanduja, Dan A, Dixon
openaire   +2 more sources