Results 61 to 70 of about 3,877 (200)
Frontiers in Neuroscience, 2018 Early brain injury (EBI) following subarachnoid hemorrhage (SAH) can lead to inflammation and neuronal dysfunction. There is a need for effective strategies to mitigate these effects and improve the outcome of patients who experience SAH.
Jian Yin +8 more
doaj +1 more source
Tristetraprolin mediates radiation-induced TNF-α production in lung macrophages. [PDF]
PLoS ONE, 2013 The efficacy of radiation therapy for lung cancer is limited by radiation-induced lung toxicity (RILT). Although tumor necrosis factor-alpha (TNF-α) signaling plays a critical role in RILT, the molecular regulators of radiation-induced TNF-α production ...
Dipankar Ray +15 more
doaj +1 more source
Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment
Frontiers in Oncology, 2021 Tristetraprolin (TTP), a well-known RNA-binding protein, primarily affects the expression of inflammation-related proteins by binding to the targeted AU-rich element in the 3’ untranslated region after transcription and subsequently mediates messenger ...
Diwen Zhang +10 more
doaj +1 more source
Cancers, 2022 Simple Summary AU-rich Element Binding Proteins (AUBPs) represent important post-transcriptional regulators of gene expression by regulating mRNA decay and/or translation.
Cyril Sobolewski +2 more
semanticscholar +1 more source
Frontiers in Aging Neuroscience, 2022 Alzheimer’s disease (AD) is a heterogeneous degenerative disorder of the brain that is on the rise worldwide. One of the critical processes that might be disturbed in AD is gene expression regulation. Tristetraprolin (TTP) and RC3H1 gene (ROQUIN) are two
M. Asadi +8 more
semanticscholar +1 more source
hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay. [PDF]
PLoS ONE, 2014 The tristetraprolin (TTP) family of zinc-finger proteins, TTP, BRF1 and BRF2, regulate the stability of a subset of mRNAs containing 3'UTR AU-rich elements (AREs), including mRNAs coding for cytokines, transcription factors, and proto-oncogenes.
Boris Reznik +2 more
doaj +1 more source
HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation
bioRxiv, 2022 Tristetraprolin (TTP) is a critical negative immune regulator. It binds AU-rich elements in the untranslated-regions of many mRNAs encoding pro-inflammatory mediators, thereby accelerating their decay.
Sara Scinicariello +14 more
semanticscholar +1 more source
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
Tristetraprolin: a novel mediator of the anticancer properties of resveratrol
Genetics and Molecular Research, 2016 Resveratrol is a natural compound that exhibits anticancer properties. Previous studies have proved that it can inhibit the proliferation of breast cancer cell lines and upregulate some cytokines such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF).
C, Li, C, Tang, G, He
openaire +2 more sources
Tristetraprolin Prevents Gastric Metaplasia in Mice by Suppressing Pathogenic InflammationSummary
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Aberrant immune activation is associated with numerous inflammatory and autoimmune diseases and contributes to cancer development and progression.
Jonathan T. Busada +8 more
doaj +1 more source