Results 51 to 60 of about 3,877 (200)
Tristetraprolin Regulates TH17 Cell Function and Ameliorates DSS-Induced Colitis in Mice
Frontiers in Immunology, 2020 TH17 cells have been extensively investigated in inflammation, autoimmune diseases, and cancer. The precise molecular mechanisms for TH17 cell regulation, however, remain elusive, especially regulation at the post-transcriptional level.
Hui Peng +10 more
doaj +1 more source
Clinical & Translational Immunology, 2019 Objective Chronic obstructive pulmonary disease (COPD) is a progressive disease that causes significant mortality and morbidity worldwide and is primarily caused by the inhalation of cigarette smoke (CS). Lack of effective treatments for COPD means there
Prema M Nair +11 more
doaj +1 more source
Journal of Inflammation, 2021 Background Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain.
Hsin-Hui Hsieh +8 more
doaj +1 more source
Tristetraprolin in cardiomyocytes has a protective role in pressure-overloaded hearts
European Heart Journal, 2023 Elevated circulating levels of TNFα, IL-6 and the soluble TNF receptors predict adverse outcomes in patients with heart failure. However, the targeted anti TNF approaches resulted in worsening heart failure or death.
S. Omiya, K. Otsu
semanticscholar +1 more source
Interferons limit inflammatory responses by induction of tristetraprolin [PDF]
Blood, 2006 Interferons (IFNs) are cytokines with pronounced proinflammatory properties. Here we provide evidence that IFNs also play a key role in decline of inflammation by inducing expression of tristetraprolin (Ttp). TTP is an RNA-binding protein that destabilizes several AU-rich element-containing mRNAs including TNFalpha.
Sauer, Ines +7 more
openaire +3 more sources
Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis
Cell Reports, 2020 Summary: The resolution phase of acute inflammation is essential for tissue homeostasis, yet the underlying mechanisms remain unclear. We demonstrate that resolution of inflammation involves interactions between CD38 and tristetraprolin (TTP). During the
Yeonsoo Joe +11 more
doaj +1 more source
Journal of Immunology, 2023 Immune evasion of Mycobacterium tuberculosis (Mtb) facilitates intracellular bacterial growth. The mechanisms of immune evasion, however, are still not fully understood. In this study, we reveal that tristetraprolin (TTP), one of the best characterized
Jianguo Liu +7 more
semanticscholar +1 more source
Tristetraprolin‐driven regulatory circuit controls quality and timing of mRNA decay in inflammation
Molecular Systems Biology, 2011 For a successful yet controlled immune response, cells need to specifically destabilize inflammatory mRNAs but prevent premature removal of those still used. The regulatory circuits controlling quality and timing in the global inflammatory mRNA decay are
Franz Kratochvill +13 more
doaj +1 more source
Serum S100A8/A9 and RNA-binding protein, tristetraprolin as prognostic markers of renal damage
Anaesthesia, Pain & Intensive Care, 2023 Background & objective: The kidneys are vital and complex organs responsible for maintaining normal body functions. Kidney disease or a loss of kidney function and, in severe cases, complete kidney failure disrupt whole of the body systems ...
Fatima Al-Zahra’a Mohammed Radhi +2 more
semanticscholar +1 more source
Clinical implications of tristetraprolin (TTP) modulation in the treatment of inflammatory diseases
Pharmacology and Therapeutics, 2022 Abnormal regulation of pro-inflammatory cytokine and chemokine mediators can contribute to the excess inflammation characteristic of many autoimmune diseases, such as rheumatoid arthritis, psoriasis, Crohn’s disease, type 1 diabetes, and many others. The
Brittany L Snyder, P. Blackshear
semanticscholar +1 more source