Results 31 to 40 of about 3,877 (200)

Tristetraprolin: Roles in cancer and senescence [PDF]

Ageing Research Reviews, 2012
Cancer and senescence are both complex transformative processes that dramatically alter many features of cell physiology and their interactions with surrounding tissues. Developing the wide range of cellular features characteristic of these conditions requires profound alterations in global gene expression patterns, which can be achieved by suppressing,
Christina R, Ross, Sarah E, Brennan-Laun, Gerald M, Wilson   +2 more
openaire   +2 more sources

Tristetraprolin Gene Single-Nucleotide Polymorphisms and mRNA Level in Patients With Rheumatoid Arthritis

Frontiers in Pharmacology, 2021
To observe and evaluate the correlation between single-nucleotide polymorphisms (SNPs) and messenger RNA (mRNA) level related to tristetraprolin (TTP) in Chinese rheumatoid arthritis (RA).
Xiaoke Yang, Bo Chen, Mingyue Zhang, Shengqian Xu, Zongwen Shuai   +4 more
doaj   +1 more source

Tristetraprolin is a novel regulator of BDNF [PDF]

SpringerPlus, 2014
AbstractBrain-derived neurotrophic factor (BDNF) regulates multiple biological processes ranging from central nervous system development and function to neuroinflammation and myogenic differentiation and repair. While coordination of BDNF levels is central in determining the biological outcome, mechanisms involved in controlling BDNF levels are not ...
Kumar, Anmol, Varendi, Kärt, Peränen, Johan, Andressoo, Jaan-Olle   +3 more
openaire   +3 more sources

The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma

Frontiers in Cell and Developmental Biology, 2023
Introduction: Asthma is the most common chronic inflammatory disease of the airways. The airway epithelium is a key driver of the disease, and numerous studies have established genome-wide differences in mRNA expression between health and asthma. However,
Jennifer Rynne, Elena Ortiz-Zapater, Elena Ortiz-Zapater, Dustin C. Bagley, Onofrio Zanin, George Doherty, Varsha Kanabar, Jon Ward, David J. Jackson, Maddy Parsons, Jody Rosenblatt, Ian M. Adcock, Rocio T. Martinez-Nunez   +12 more
doaj   +1 more source

Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice

Frontiers in Immunology, 2020
Tristetraprolin (TTP) is a mRNA binding protein that binds to adenylate-uridylate-rich elements within the 3′ untranslated regions of certain transcripts, such as tumor necrosis factor (Tnf) mRNA, and increases their rate of decay.
Ishita Choudhary, Thao Vo, Chandra S. Bathula, Richa Lamichhane, Brandon W. Lewis, Jayme Looper, Samithamby Jeyaseelan, Perry J. Blackshear, Yogesh Saini, Sonika Patial   +9 more
doaj   +1 more source

The Stability of Tristetraprolin mRNA Is Regulated by Mitogen-activated Protein Kinase p38 and by Tristetraprolin Itself [PDF]

Journal of Biological Chemistry, 2004
Tristetraprolin (TTP) is an mRNA-destabilizing protein that negatively regulates the expression of proinflammatory mediators such as tumor necrosis factor alpha, granulocyte/macrophage colony-stimulating factor, and cyclooxygenase 2. Here we investigate the regulation of TTP expression in the mouse macrophage cell line RAW264.7.
Tchen, C, Brook, M, Saklatvala, J, Clark, A   +3 more
openaire   +3 more sources

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

eLife, 2023
Tristetraprolin (TTP) is a critical negative immune regulator. It binds AU-rich elements in the untranslated-regions of many mRNAs encoding pro-inflammatory mediators, thereby accelerating their decay.
Sara Scinicariello, Adrian Soderholm, Markus Schäfer, Alexandra Shulkina, Irene Schwartz, Kathrin Hacker, Rebeca Gogova, Robert Kalis, Kimon Froussios, Valentina Budroni, Annika Bestehorn, Tim Clausen, Pavel Kovarik, Johannes Zuber, Gijs A Versteeg   +14 more
doaj   +1 more source

Regulation and localization of endogenous human tristetraprolin [PDF]

Arthritis Res Ther, 2003
Tumor necrosis factor (TNF) has been implicated in the development and pathogenicity of infectious diseases and autoimmune disorders, such as septic shock and arthritis. The zinc-finger protein tristetraprolin (TTP) has been identified as a major regulator of TNF biosynthesis.
Fairhurst, Anna-Marie, Connolly, John E, Hintz, Katharine A, Goulding, Nicolas J, Rassias, Athos J, Yeager, Mark P, Rigby, William, Wallace, Paul K   +7 more
openaire   +2 more sources

Tristetraprolin, Inflammation, and Metabolic Syndrome in Arab Adults: A Case Control Study

Biology, 2021
Tristetraprolin (TTP) is an mRNA binding protein suggested to have a substantial role in regulating the mRNA expression of numerous inflammatory factors, but data on TTP and its association with metabolic syndrome (MetS), a chronic low-grade inflammatory
Nasser M. Al-Daghri, Albatul Y.A. Al-Shuwaie, Amani Alghamdi, Osama E. Amer, Malak N.K. Khattak, Mohammed G.A. Ansari, Abdullah M. Alnaami, Shaun Sabico   +7 more
doaj   +1 more source

Tristetraprolin Is Required for Alveolar Bone Homeostasis [PDF]

Journal of Dental Research, 2018
Tristetraprolin (TTP) is an RNA-binding protein that targets numerous immunomodulatory mRNA transcripts for degradation. Many TTP targets are key players in the pathogenesis of periodontal bone loss, including tumor necrosis factor–α. To better understand the extent that host immune factors play during periodontal bone loss, we assessed alveolar bone ...
H M, Steinkamp, J D, Hathaway-Schrader, M B, Chavez, J D, Aartun, L, Zhang, T, Jensen, A, Shojaee Bakhtiari, K L, Helke, D J, Stumpo, A V, Alekseyenko, C M, Novince, P J, Blackshear, K L, Kirkwood   +12 more
openaire   +2 more sources