Results 21 to 30 of about 3,877 (200)

Tristetraprolin-mediated mRNA destabilization regulates basophil inflammatory responses

Allergology International
Background: Basophils, despite being the least common granulocytes, play crucial roles in type 2 immune responses, such as chronic allergic inflammation and protective immunity against parasites.
Junya Ito, Kensuke Miyake, Tomoki Chiba, Kazufusa Takahashi, Yutaro Uchida, Perry J. Blackshear, Hiroshi Asahara, Hajime Karasuyama   +7 more
doaj   +2 more sources

Tristetraprolin promotes survival of mammary progenitor cells by restraining TNFα levels

Frontiers in Cell and Developmental Biology, 2023
Tristetraprolin (TTP) is an RNA binding protein that destabilizes mRNAs of factors involved in proliferation, invasiveness, and inflammation. Disruption of the gene that codes for TTP (Zfp36) led to severe arthritis, autoimmunity, cachexia and dermatitis
Micaela Stedile, Angela Lara Montero, Martín Emilio García Solá, María Victoria Goddio, Inés Beckerman, Emilia Bogni, Marina Ayre, Zaira Naguila, Omar A. Coso, Omar A. Coso, Edith C. Kordon, Edith C. Kordon   +11 more
doaj   +2 more sources

PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis

Molecular Oncology, 2018
Tristetraprolin (TTP) is an AU‐rich element‐binding protein that regulates mRNA stability and plays important roles in cancer. The mechanisms by which TTP is regulated in breast cancer are poorly understood.
Chune Ren, Pengyun Qiao, Shijun Lv
exaly   +2 more sources

The Tristetraprolin Family of RNA-Binding Proteins in Cancer: Progress and Future Prospects

Cancers, 2020
Post-transcriptional regulation of gene expression plays a key role in cellular proliferation, differentiation, migration, and apoptosis. Increasing evidence suggests dysregulated post-transcriptional gene expression as an important mechanism in the ...
Yogesh Saini, Sonika Patial, Saini Yogesh   +2 more
exaly   +2 more sources

Tristetraprolin expression by keratinocytes protects against skin carcinogenesis [PDF]

JCI Insight, 2021
Cancer is caused primarily by genomic alterations resulting in deregulation of gene regulatory circuits in key growth, apoptosis, or DNA repair pathways.
Assiya Assabban, Ingrid Dubois-Vedrenne, Laurye Van Maele, Rosalba Salcedo, Brittany L. Snyder, Lecong Zhou, Abdulkader Azouz, Bérengère de Toeuf, Gaëlle Lapouge, Caroline La, Maxime Melchior, Muriel Nguyen, Séverine Thomas, Si Fan Wu, Wenqian Hu, Véronique Kruys, Cédric Blanpain, Giorgio Trinchieri, Cyril Gueydan, Perry J. Blackshear, Stanislas Goriely   +20 more
doaj   +4 more sources

Tristetraprolin regulation of interleukin-22 production [PDF]

Scientific Reports, 2015
AbstractInterleukin (IL)-22 is a STAT3-activating cytokine displaying characteristic AU-rich elements (ARE) in the 3′-untranslated region (3′-UTR) of its mRNA. This architecture suggests gene regulation by modulation of mRNA stability. Since related cytokines undergo post-transcriptional regulation by ARE-binding tristetraprolin (TTP), the role of this
Härdle, Lorena, Bachmann, Malte, Bollmann, Franziska, Pautz, Andrea, Schmid, Tobias, Eberhardt, Wolfgang, Kleinert, Hartmut, Pfeilschifter, Josef, Mühl, Heiko   +8 more
openaire   +6 more sources

Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1. [PDF]

PLoS ONE, 2012
BACKGROUND: Tristetraprolin binds mRNA AU-rich elements and thereby facilitates the destabilization of mature mRNA in the cytosol. METHODOLOGY/PRINCIPAL FINDINGS: To understand how tristetraprolin mechanistically functions, we biopanned with a phage ...
Yu-Lun Su, Shun-Chang Wang, Pei-Yu Chiang, Nien-Yi Lin, Yu-Fang Shen, Geen-Dong Chang, Ching-Jin Chang   +6 more
doaj   +1 more source

Post-Transcriptional Regulation of Immune Responses and Inflammatory Diseases by RNA-Binding ZFP36 Family Proteins

Frontiers in Immunology, 2021
Post-transcriptional regulation is involved in the regulation of many inflammatory genes. Zinc finger protein 36 (ZFP36) family proteins are RNA-binding proteins involved in messenger RNA (mRNA) metabolism pathways. The ZFP36 family is composed of ZFP36 (
Sohei Makita, Hiroaki Takatori, Hiroaki Takatori, Hiroshi Nakajima   +3 more
doaj   +1 more source

Phosphorylation of Recombinant Tristetraprolin In vitro [PDF]

The Protein Journal, 2007
Tristetraprolin/zinc finger protein 36 (TTP/ ZFP36) binds and destabilizes some proinflammatory cytokine mRNAs. TTP-deficient mice develop a profound inflammatory syndrome due to excessive production of proinflammatory cytokines. TTP gene expression is induced by various factors including insulin, cinnamon, and green tea extracts. Previous studies have
Heping, Cao, Rui, Lin
openaire   +2 more sources

The role of tristetraprolin in cancer and inflammation [PDF]

Frontiers in Bioscience, 2012
Messenger RNA decay is a critical mechanism to control the expression of many inflammation- and cancer-associated genes. These transcripts are targeted for rapid degradation through AU-rich element (ARE) motifs present in the mRNA 3' untranslated region (3'UTR). Tristetraprolin (TTP) is an RNA-binding protein that plays a significant role in regulating
Sandhya, Sanduja, Fernando F, Blanco, Lisa E, Young, Vimala, Kaza, Dan A, Dixon   +4 more
openaire   +2 more sources