Results 11 to 20 of about 3,877 (200)

Tristetraprolin affects invasion-associated genes expression and cell motility in triple-negative breast cancer model. [PDF]

Cytoskeleton (Hoboken)
Tristetraprolin (TTP) is an RNA‐binding protein that negatively regulates its target mRNAs and has been shown to inhibit tumor progression and invasion.
Hubiernatorova A, Novak J, Vaskovicova M, Sekac D, Kropyvko S, Hodny Z.   +5 more
europepmc   +3 more sources

Role of Tristetraprolin in the Resolution of Inflammation [PDF]

Biology, 2021
Inflammation is a crucial part of immune responses towards invading pathogens or tissue damage. While inflammatory reactions are aimed at removing the triggering stimulus, it is important that these processes are terminated in a coordinate manner to ...
Peter Rappl, Bernhard Brüne, Tobias Schmid   +2 more
doaj   +5 more sources

Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells

Frontiers in Immunology, 2022
Aging results in enhanced myelopoiesis, which is associated with an increased prevalence of myeloid leukemias and the production of myeloid-derived suppressor cells (MDSCs).
Kyu Hwan Kwack, Kyu Hwan Kwack, Lixia Zhang, Elliot D. Kramer, Elliot D. Kramer, Ramkumar Thiyagarajan, Ramkumar Thiyagarajan, Ramkumar Thiyagarajan, Natalie A. Lamb, Natalie A. Lamb, Yukitomo Arao, Jonathan E. Bard, Jonathan E. Bard, Kenneth L. Seldeen, Kenneth L. Seldeen, Kenneth L. Seldeen, Bruce R. Troen, Bruce R. Troen, Bruce R. Troen, Perry J. Blackshear, Perry J. Blackshear, Scott I. Abrams, Keith L. Kirkwood, Keith L. Kirkwood   +23 more
doaj   +2 more sources

Tristetraprolin Family Members and Processing Bodies: A Complex Regulatory Network Involved in Fatty Liver Disease, Viral Hepatitis and Hepatocellular Carcinoma. [PDF]

Cancers (Basel)
Simple Summary Tristetraprolin (TTP) family members are major regulators of gene expression involved in metabolic, inflammatory and carcinogenic processes.
Gellée N, Legrand N, Jouve M, Devaux PJ, Dubuquoy L, Sobolewski C.   +5 more
europepmc   +2 more sources

RNA-binding protein tristetraprolin inhibits Th2 cell activation and differentiation in allergic rhinitis by promoting TRIM18 mRNA decay. [PDF]

J Biol Chem
Tristetraprolin (TTP), which encodes an RNA-binding protein, was identified as a biomarker in three types of IgE-driven allergic tissues. Remarkably, in the nasal mucosa of the ragweed pollen-induced AR mouse model, TTP mRNA levels were increased ...
Xing D, Cao H, Yang Y, Liu S, Yu H, Liu Z, Wang K, Wei X, Yan A.   +8 more
europepmc   +2 more sources

GLA-3 mediates the heat shock response in Caenorhabditis elegans germ cells: A key role for the tristetraprolin (TTP) family. [PDF]

PLoS One
Tristetraprolin or TTP is an RNA-binding protein that possesses two CCCH-like zinc-finger domains that bind AU-rich elements to promote their degradation. One of its targets is the mRNA of tumor necrosis factor alpha (TNF-α).
Salinas LS, Dámazo-Hernández ÁA, Cristino-Miranda AM, Zurita-León M, Morales-Oliva E, Láscarez-Lagunas LI, Navarro RE.   +6 more
europepmc   +2 more sources

Tristetraprolin Posttranscriptionally Downregulates TRAIL Death Receptors [PDF]

Cells, 2020
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has attracted attention as a potential candidate for cancer therapy. However, many primary cancers are resistant to TRAIL, even when combined with standard chemotherapy.
Won Hyeok Lee, Myung Woul Han, Song Hee Kim, Daseul Seong, Jae Hee An, Hyo Won Chang, Sang Yoon Kim, Seong Who Kim, Jong Cheol Lee   +8 more
doaj   +3 more sources

Shiga Toxins Produced by Enterohaemorrhagic Escherichia coli Induce Inflammation in Toxin-Sensitive Cells through the p38 MAPK/MK2/Tristetraprolin Signaling Pathway. [PDF]

J Microbiol Biotechnol
Shiga toxins (Stxs), produced by Shigella dysenteriae serotype 1 and certain Escherichia coli pathotypes, cause hemorrhagic colitis, which can progress to hemolytic uremic syndrome (HUS) and central nervous system (CNS) pathology.
Park SY, Jeong YJ, Lee KS, Park JY, Park J, Tesh VL, Lee MS.   +6 more
europepmc   +2 more sources

miR-182-5p attenuates Schistosoma japonicum-induced hepatic fibrosis by targeting tristetraprolin

Acta Biochimica et Biophysica Sinica, 2022
Egg granuloma formation in the liver is the main pathological lesion caused by Schistosoma japonicum infection, which generally results in liver fibrosis and may lead to death in advanced patients.
Zhao Xuejun, Xia Zijie, Wang Ziang, Zhou Mengsi, Qiu Xuebing, Wang Cheng, Xu Tian, Fang Qian, Ming Zhenping, Dong Huifen   +9 more
doaj   +2 more sources

Low tristetraprolin expression activates phenotypic plasticity and primes transition to lethal prostate cancer in mice. [PDF]

J Clin Invest
Phenotypic plasticity is a hallmark of cancer and is increasingly realized as a mechanism of resistance to androgen receptor–targeted (AR-targeted) therapy.
Morel KL, Germán B, Hamid AA, Nanda JS, Linder S, Bergman AM, van der Poel H, Hofland I, Bekers EM, Trostel SY, Burkhart DL, Wilkinson S, Ku AT, Kim M, Kim J, Ma D, Plummer JT, You S, Su XA, Zwart W, Sowalsky AG, Sweeney CJ, Ellis L.   +22 more
europepmc   +2 more sources