Results 41 to 50 of about 3,877 (200)
Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay
eLife, 2015 Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population.
Melissa A Hausburg +7 more
doaj +1 more source
Frontiers in Immunology, 2020 The bioavailability of the major pro-inflammatory cytokines IL-1α and IL-1β is tightly controlled by transcription and post-translational processing to prevent hyperinflammation.
Lucy Sneezum +8 more
doaj +1 more source
Tristetraprolin as a Therapeutic Target in Inflammatory Disease [PDF]
Trends in Pharmacological Sciences, 2016 Members of the tristetraprolin (TTP) family of RNA-binding proteins are found in all major eukaryotic groups. TTP family members, from plants through humans, can bind adenosine-uridine rich elements in target mRNAs with high affinity. In mammalian cells, these proteins then promote deadenylation and decay of target transcripts.
Sonika, Patial, Perry J, Blackshear
openaire +2 more sources
RNA Biology, 2023 Inhibition of apoptosis is one of the hallmarks of cancer and is a target of various therapeutic interventions. BIRC5 is an inhibitor of apoptosis that is aberrantly expressed in cancer leading to sustained growth of tumours. Post-transcriptional control
Suhad Al-Yahya +5 more
semanticscholar +1 more source
Decreased Sensitivity of Tristetraprolin-deficient Cells to p38 Inhibitors Suggests the Involvement of Tristetraprolin in the p38 Signaling Pathway [PDF]
Journal of Biological Chemistry, 2001 Treatment of macrophages with pyridinyl imidazole inhibitors of p38 protein kinases can inhibit lipopolysaccharide-stimulated tumor necrosis factor alpha secretion. However, bone marrow-derived macrophages from tristetraprolin (TTP)-deficient mice were less sensitive than normal macrophages to this effect of p38 inhibitors, despite evidence for normal ...
E, Carballo +5 more
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International Journal of Ophthalmology, 2014 AIM:To examine the effect of intravitreal adenoviral vector-mediated tristetraprolin (Ad-TTP) on VEGF mRNA expression in a rat model of laser-induced choroidal neovascularization.METHODS:Ad-TTP was prepared using a commercial kit.
Yong Wun Cho +6 more
doaj +1 more source
Tristetraprolin targets Nos2 expression in the colonic epithelium [PDF]
Scientific Reports, 2019 AbstractTristetraprolin (TTP), encoded by the Zfp36 gene, is a zinc-finger protein that regulates RNA stability primarily through association with 3′ untranslated regions (3′ UTRs) of target mRNAs. While TTP is expressed abundantly in the intestines, its function in intestinal epithelial cells (IECs) is unknown.
Melanie A. Eshelman +9 more
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Tristetraprolin Mediates Interferon-γ mRNA Decay [PDF]
Journal of Biological Chemistry, 2009 Tristetraprolin (TTP) regulates expression at the level of mRNA decay of several cytokines, including the T cell-specific cytokine, interleukin-2. We performed experiments to determine whether another T cell-specific cytokine, interferon-gamma (IFN-gamma), is also regulated by TTP and found that T cell receptor-activated T cells from TTP knock-out mice
Rachel L, Ogilvie +7 more
openaire +2 more sources
GeroScience, 2023 Tristetraprolin (TTP), encoded by Zfp36 in mice, is one of the best-characterized tandem zinc-finger mRNA binding proteins involved in mRNA deadenylation and decay. TTPΔARE mice lack an AU-rich motif in the 3′-untranslated regions of TTP mRNA, leading to
Mayuri Tanaka-Yano +6 more
semanticscholar +1 more source
Effect of the p53-tristetraprolin-stathmin-1 pathway on trophoblasts at maternal-fetal interface. [PDF]
PLoS ONE, 2017 To reveal the effect of p53-tristetraprolin-stathmin-1 signaling on trophoblasts and recurrent spontaneous abortion (RSA).Stathmin-1 (STMN1), p53, and tristetraprolin (TTP) expression in paraffin-embedded villus tissue was determined using ...
Xiao-Ling Ma +7 more
doaj +1 more source