Results 71 to 80 of about 3,877 (200)

The Conserved CNOT1 Interaction Motif of Tristetraprolin Regulates ARE-mRNA Decay Independently of the p38 MAPK-MK2 Kinase Pathway

bioRxiv, 2022
The regulation of the mRNA decay activator Tristetraprolin (TTP) by the p38 mitogen-activated protein kinase (MAPK) pathway during the mammalian inflammatory response represents a paradigm for the control of mRNA turnover by signaling.
Alberto Carreño, J. Lykke-Andersen
semanticscholar   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Inhibition of tristetraprolin deadenylation by poly(A) binding protein

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2008
Tristetraprolin (TTP) is the prototype for a family of RNA binding proteins that bind the tumor necrosis factor (TNF) messenger RNA AU-rich element (ARE), causing deadenylation of the TNF poly(A) tail, RNA decay, and silencing of TNF protein production. Using mass spectrometry sequencing we identified poly(A) binding proteins-1 and -4 (PABP1 and PABP4)
Robert M, Rowlett, Carol A, Chrestensen, Melanie J, Schroeder, Mary G, Harp, Jared W, Pelo, Jeffery, Shabanowitz, Robert, DeRose, Donald F, Hunt, Thomas W, Sturgill, Mark T, Worthington   +9 more
openaire   +3 more sources

Stability of the LATS2 Tumor Suppressor Gene Is Regulated by Tristetraprolin [PDF]

Journal of Biological Chemistry, 2010
LATS2 is a tumor suppressor gene implicated in the control of cell growth and the cell cycle. Here, we investigated the post-transcriptional regulation of LATS2 expression by tristetraprolin (TTP). Our results show that the expression level of LATS2 is inversely correlated with TTP expression in human cancer cell lines.
Hyun Hee, Lee, Mai-Tram, Vo, Hyo Jeong, Kim, Unn Hwa, Lee, Chae Won, Kim, Hong Kyeung, Kim, Myoung Seok, Ko, Won Hyuck, Lee, Seung Joo, Cha, Young Joo, Min, Dae Hwa, Choi, Ho Seok, Suh, Byung Ju, Lee, Jeong Woo, Park, Wha Ja, Cho   +14 more
openaire   +2 more sources

The Role of Long Noncoding RNAs in Modulation of Stress Granules in Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Stress granules are dynamic cellular structures that arise in response to stress. They play an important role in cancer cell survival by modulating multiple stress responses. Long noncoding RNAs (lncRNAs) have been identified as crucial regulators of stress granule (SG) dynamics, influencing cancer development and treatment resistance. LncRNAs
Nazlı Şevval Menemenli, Bünyamin Akgül   +1 more
wiley   +1 more source

Tristetraprolin regulates phagocytosis through interaction with CD47 in head and neck cancer

Experimental and Therapeutic Medicine, 2022
CD47 is expressed in all human cancer cells, including head and neck cancer, and initiates a signaling cascade to inhibit macrophage phagocytosis. However, the mechanism underlying CD47 overexpression has not been elucidated in radioresistant head and ...
W. Lee, S. Kim, J. An, Tae-Koon Kim, H. Cha, H. Chang, S. Y. Kim, Seong Who Kim, M. Han   +8 more
semanticscholar   +1 more source

A Gene Expression Tumor Signature Optimizing Partial Area‐Under‐the‐Curve (pAUC) to Improve Specificity for Indolent Prostate Cancer

The Prostate, Volume 86, Issue 9, Page 1075-1082, June 15, 2026.
ABSTRACT Purpose A key clinical challenge in prostate cancer is the identification and validation of biomarkers with high specificity for indolent long‐term outcomes. We applied a novel statistical method to identify tumor transcriptomic biomarkers that optimally predicted patients with low metastatic potential.
Travis A. Gerke, Svitlana Tyekucheva, Konrad H. Stopsack, Christopher J. Sweeney, Rosina T. Lis, Elizabeth N. Westling, Massimo Loda, Meir J. Stampfer, Kathryn L. Penney, Giovanni Parmigiani, Lorelei A. Mucci   +10 more
wiley   +1 more source

Tristetraprolin expression by keratinocytes controls local and systemic inflammation [PDF]

JCI Insight, 2017
Tristetraprolin (TTP, encoded by the Zfp36 gene) regulates the mRNA stability of several important cytokines. Due to the critical role of this RNA-binding protein in the control of inflammation, TTP deficiency leads to the spontaneous development of a complex inflammatory syndrome.
Andrianne, Mathieu, Assabban, Assiya, La, Caroline, Mogilenko, Denis, Salle, Delphine Staumont, Fleury, Sébastien, Doumont, Gilles, van Simaeys, Gaëtan, Nedospasov, Sergei, Dombrowicz, David, Blackshear, Perry, Goriely, Stanislas, van Maele, Laurye   +12 more
openaire   +3 more sources

Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin

Journal of Experimental Medicine, 2021
Group 2 innate lymphoid cells (ILC2s) are unique in their ability to produce low levels of type 2 cytokines at steady state, and their production capacity is dramatically increased upon stimulation with IL-33. However, it is unknown how constitutive cytokine production is regulated in the steady state.
Yuki Hikichi, Yasutaka Motomura, Osamu Takeuchi, Kazuyo Moro   +3 more
openaire   +2 more sources