Results 131 to 140 of about 35,994 (298)
MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.IDD and OA is caused by various mechanisms, creating a vicious cycle that impairs disc function. Nanozymes and nano‐enzyme delivery systems offer innovative therapies by targeting these underlying mechanisms, such as anti‐inflammatory therapy, ECM repair, cellular dysfunction and antioxidant therapy, providing a promising approach to restoring tissue ...
Lei Peng +4 more
wiley +1 more source
Communications Biology, 2020 Using genetic code expansion, Zhao, Shi et al. generate light-sensitive tyrosine analogues to obtain insights into the activation of the NGF receptor, TrkA.
Shu Zhao +10 more
doaj +1 more source
International Journal of Molecular Sciences, 2017 Dysfunction of nerve growth factor (NGF) and its high-affinity Tropomyosin receptor kinase A (TrkA) receptor has been suggested to contribute to the selective degeneration of basal forebrain cholinergic neurons (BFCN) associated with the progressive ...
N. Canu +8 more
semanticscholar +1 more source
The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases
MedComm, Volume 6, Issue 6, June 2025.Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu +7 more
wiley +1 more source
TrkA glycosylation regulates receptor localization and activity
Journal of Neurobiology, 1999 The human nerve growth factor receptor (TrkA) contains four potential N-glycosylation sites that are highly conserved within the Trk family of neurotrophin receptors, and nine additional sites that are less well conserved. Using a microscale deglycosylation assay, we show here that both conserved and variable N-glycosylation sites are used during ...
Fiona L. Watson +5 more
openaire +3 more sources
Biogenesis and Function of the NGF/TrkA Signaling Endosome [PDF]
, 2015 Target-derived neurotrophin nerve growth factor (NGF) and its receptor TrkA are well known for retrograde signaling to promote survival and innervation of sympathetic and sensory neurons. In recent years, the signaling endosome model has been used to describe the sustained NGF/TrkA retrograde signaling as a process of endocytosis and retrograde ...
M. Caleb Marlin, Guangpu Li
openaire +3 more sources
Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging
Pharmaceuticals, 2019 The tropomyosin receptor kinases family (TrkA, TrkB, and TrkC) supports neuronal growth, survival, and differentiation during development, adult life, and aging.
Ralf Schirrmacher +17 more
doaj +1 more source
Association between Tetrodotoxin Resistant Channels and Lipid Rafts Regulates Sensory Neuron Excitability [PDF]
, 2012 PubMed ID: 22870192This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Baker, MD, Okuse, K, Pristera, A
core +3 more sources
Structural characterization of nonactive site, TrkA-selective kinase inhibitors
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Signal transduction through Tropomyosin-related kinase A (TrkA), a receptor tyrosine kinase, is a target for inhibition of chronic pain and could lead to a new class of drugs against pain.
H. Su +29 more
semanticscholar +1 more source