Results 131 to 140 of about 34,874 (291)

Structural characterization of nonactive site, TrkA-selective kinase inhibitors

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance Signal transduction through Tropomyosin-related kinase A (TrkA), a receptor tyrosine kinase, is a target for inhibition of chronic pain and could lead to a new class of drugs against pain.
H. Su, K. Rickert, Christine Burlein, Kartik Narayan, M. Bukhtiyarova, Danielle M. Hurzy, C. Stump, Xu-Fang Zhang, J. Reid, Alicja Krasowska‐Zoladek, S. Tummala, J. Shipman, M. Kornienko, P. Lemaire, D. Krosky, Amanda Heller, A. Achab, Chad Chamberlin, P. Saradjian, B. Sauvagnat, Xianshu Yang, M. Ziebell, E. Nickbarg, J. Sanders, M. Bilodeau, S. Carroll, K. Lumb, S. Soisson, D. Henze, A. Cooke   +29 more
semanticscholar   +1 more source

TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines. [PDF]

, 2015
Background: The nerve growth factor (NGF) receptor tyrosine-kinase TrkA is a well-known determinant of the melanocytic lineage, through modulation of the MAPK and AKT cascades.
Adami V, Pasini L, Quattrone A, Re A, Ricci G, Tebaldi T   +5 more
core   +1 more source

Decoding Microbial Plastic Colonisation: Multi‐Omic Insights Into the Fast‐Evolving Dynamics of Early‐Stage Biofilms

PROTEOMICS, Volume 25, Issue 7, April 2025.
ABSTRACT Marine plastispheres represent dynamic microhabitats where microorganisms colonise plastic debris and interact. Metaproteomics has provided novel insights into the metabolic processes within these communities; however, the early metabolic interactions driving the plastisphere formation remain unclear.
Charlotte E. Lee, Lauren F. Messer, Ruddy Wattiez, Sabine Matallana‐Surget   +3 more
wiley   +1 more source

TrkA glycosylation regulates receptor localization and activity

Journal of Neurobiology, 1999
The human nerve growth factor receptor (TrkA) contains four potential N-glycosylation sites that are highly conserved within the Trk family of neurotrophin receptors, and nine additional sites that are less well conserved. Using a microscale deglycosylation assay, we show here that both conserved and variable N-glycosylation sites are used during ...
Fiona L. Watson, Anita Bhattacharyya, Rosalind A. Segal, Rosalind A. Segal, Marimelia Porcionatto, Charles D. Stiles   +5 more
openaire   +3 more sources

Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging

Pharmaceuticals, 2019
The tropomyosin receptor kinases family (TrkA, TrkB, and TrkC) supports neuronal growth, survival, and differentiation during development, adult life, and aging.
Ralf Schirrmacher, Justin J. Bailey, Andrew V. Mossine, Peter J. H. Scott, Lena Kaiser, Peter Bartenstein, Simon Lindner, David R. Kaplan, Alexey Kostikov, Gert Fricker, Anne Mahringer, Pedro Rosa-Neto, Esther Schirrmacher, Carmen Wängler, Björn Wängler, Alexander Thiel, Jean-Paul Soucy, Vadim Bernard-Gauthier   +17 more
doaj   +1 more source

Nerve growth factor is expressed by postmitotic avian retinal horizontal cells and supports their survival during development in an autocrine mode of action. [PDF]

, 2001
Cell death in the developing retina is regulated, but so far little is known about what factors regulate the cell death. Several neurotrophic factors and receptors, including the neurotrophins and Trk receptors, are expressed during the critical time. We
Catsicas, S, Hallbook, F, Karlsson, M, Karten, H, Mayordomo, R, Reichardt, LF   +5 more
core  

Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents

Frontiers in Molecular Neuroscience, 2017
The amyloid precursor protein (APP) interacts with the tropomyosin receptor kinase A (TrkA) in normal rat, mouse, and human brain tissue but not in Alzheimer’s disease (AD) brain tissue. However, it has not been reported whether the two proteins interact
N. Canu, Ilaria Pagano, L. R. La Rosa, M. Pellegrino, M. Ciotti, D. Mercanti, F. Moretti, V. Sposato, V. Triaca, C. Petrella, I. Maruyama, A. Levi, P. Calissano   +12 more
semanticscholar   +1 more source

Mutations in TrkA Causing Congenital Insensitivity to Pain with Anhidrosis (CIPA) Induce Misfolding, Aggregation, and Mutation-dependent Neurodegeneration by Dysfunction of the Autophagic Flux*

Journal of Biological Chemistry, 2016
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder characterized by insensitivity to noxious stimuli and variable intellectual disability (ID) due to mutations in the NTRK1 gene encoding the NGF receptor TrkA ...
M. L. Franco, C. Melero, E. Sarasola, P. Acebo, A. Luque, Isabel Calatayud-Baselga, M. García-Barcina, M. Vilar   +7 more
semanticscholar   +1 more source

Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles in vitro.

PLoS ONE, 2019
The human hair follicle is a neuroendocrine mini-organ that can be used to study aging processes in vitro. Neurotrophins maintain homeostasis in hair biology via the Trk-family of receptors. TrkA, the high affinity receptor for nerve growth factor (NGF),
Remo Campiche, Maria Daniltchenko, Dominik Imfeld, Eva M J Peters   +3 more
doaj   +1 more source

Expression of Nerve Growth Factor (NGF) and Its Receptors TrkA and p75 in the Reproductive Organs of Laying Hens

Brazilian Journal of Poultry Science, 2016
In order to investigate the expression levels of nerve growth factor (NGF) and its receptors (TrkA and p75) in prehierarchical follicles and oviducts of hens, five 130-day-old laying hens were examined by immunohistochemistry and RT-PCR analysis. NGF and
PU Shaoxia, QU Changwei, LI Zhi, LI Yansen, LI ChunMei   +4 more
doaj   +1 more source