Results 101 to 110 of about 404,299 (351)

Gene Editing of a Susceptibility LncRNA Enhances Broad‐Spectrum Disease Resistance in Rice without Developmental Trade‐Offs

Advanced Science, EarlyView.
Editing susceptibility lncRNAs offers a strategy to enhance disease resistance without yield loss. RESIS, a domestication‐acquired, pathogen‐induced lncRNA, promotes protein N‐terminal acetylation through its interaction with NatA complex. Knockout of RESIS increases translation and confers broad‐spectrum resistance to both fungal and bacterial ...
Wen‐long Zhao, Ye Cheng, Jia‐hui Huang, Jun‐jie Feng, Hui‐yin Pang, Yi‐chao Qin, Zheng‐tong Chen, Yu Cheng, Jian‐ping Lian, Yan‐fei Zhou, Rui‐rui He, Meng‐qi Lei, Zi‐qin Cao, Lu Yang, Chao Yuan, Jie Jiang, Yue‐qin Chen, Yu‐chan Zhang   +17 more
wiley   +1 more source

Unexpected Accumulation of ncm\u3csup\u3e5\u3c/sup\u3eU and ncm\u3csup\u3e5\u3c/sup\u3es\u3csup\u3e2\u3c/sup\u3eU in a \u3cem\u3etrm9\u3c/em\u3e Mutant Suggests an Additional Step in the Synthesis of mcm\u3csup\u3e5\u3c/sup\u3eU and mcm\u3csup\u3e5\u3c/sup\u3es\u3csup\u3e2\u3c/sup\u3eU [PDF]

, 2011
Background Transfer RNAs are synthesized as a primary transcript that is processed to produce a mature tRNA. As part of the maturation process, a subset of the nucleosides are modified.
Anderson, James T., Byström, Anders S., Chen, Changchun, Huang, Bo   +3 more
core   +1 more source

The role of RNA modifications in the regulation of tRNA cleavage

FEBS Letters, 2018
Transfer RNA (tRNA) have been harbingers of many paradigms in RNA biology. They are among the first recognized noncoding RNA (ncRNA) playing fundamental roles in RNA metabolism.
Shawn M. Lyons, Marta M. Fay, P. Ivanov
semanticscholar   +1 more source

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

Nastává éra mezioborových didaktik?

Pedagogická Orientace, 2005
Jádrem příspěvku je myšlenka konstituování mezioborových didaktik. Jde o reakci na popsanou aktuální problematiku oborových didaktik v době rychlých kurikulárních změn, zejména při zavádění rámcových vzdělávacích programů.
J. Trna
doaj  

Extracellular tyrosyl‐tRNA synthetase cleaved by plasma proteinases and stored in platelet α‐granules: Potential role in monocyte activation

Research and Practice in Thrombosis and Haemostasis, 2020
Background Tyrosyl‐tRNA synthetase (YRS) belongs to the family of enzymes that catalyzes the tRNA aminoacylation reaction for protein synthesis, and it has been recently shown to exert noncanonical functions.
Eric Won, Yosuke Morodomi, Sachiko Kanaji, Ryan Shapiro, My‐Nuong Vo, Jennifer N. Orje, Courtney D. Thornburg, Xiang‐Lei Yang, Zaverio M. Ruggeri, Paul Schimmel, Taisuke Kanaji   +10 more
doaj   +1 more source

tRNA functional signatures classify plastids as late-branching cyanobacteria. [PDF]

, 2019
BackgroundEukaryotes acquired the trait of oxygenic photosynthesis through endosymbiosis of the cyanobacterial progenitor of plastid organelles. Despite recent advances in the phylogenomics of Cyanobacteria, the phylogenetic root of plastids remains ...
Amrine, Katherine Ch, Ardell, David H, Lawrence, Travis J, Swingley, Wesley D   +3 more
core   +1 more source

Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery [PDF]

, 2023
Ze Liu, Justin Wang, Yi Shi, Brian A. Yee, Markus Terrey, Qian Zhang, Jenq‐Chang Lee, Kuo‐I Lin, Andrew H.‐J. Wang, Susan L. Ackerman, G Yeo, Haissi Cui, Xiang-Lei Yang   +12 more
openalex   +1 more source

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Nucleic Acids Research, 2018
Transfer RNAs (tRNAs) are non-coding RNA molecules essential for protein synthesis. Post-transcriptionally they are heavily modified to improve their function, folding and stability.
C. Cosentino, Sanna Toivonen, Esteban Diaz Villamil, M. Atta, J. Ravanat, Stéphane Demine, A. Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, J. Jonas, Diego Balboa, T. Otonkoski, E. Pearson, P. Marchetti, D. Eizirik, M. Cnop, M. Igoillo-Esteve   +16 more
semanticscholar   +1 more source

MicroRNA‐Enriched Plant‐Derived Exosomes Alleviate Colitis by Modulating Systemic Immunity, Metabolic Homeostasis, and Gut Microbiota

Advanced Science, EarlyView.
Herbal medicine, with its multicomponent and multitarget potential, is often studied primarily for traditional forms, especially phytochemicals. Currently, ulcerative colitis lacks natural, low‐toxicity therapies, yet emerging research highlights plant‐derived exosomes as a promising option.
Ruipeng Shi, Wen Tan, Haochun Jin, Sio I Chan, Wei Li, Si San Lei, Guozhen Cui, Yitao Wang, Dong‐Hua Yang, Zhangfeng Zhong   +9 more
wiley   +1 more source