Results 141 to 150 of about 241,053 (344)
The RNA degradosome promotes tRNA quality control through clearance of hypomodified tRNA
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The cellular mechanisms governing tRNA stability in bacteria are not well understood, and in contrast to eukaryotes, a bacterial system for degradation of mature tRNAs has not been described.
S. Kimura, M. Waldor
semanticscholar +1 more source
Advanced Science, EarlyView.The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee +28 more
wiley +1 more source
Multiple Layers of Stress-Induced Regulation in tRNA Biology
Life, 2016 tRNAs are the fundamental components of the translation machinery as they deliver amino acids to the ribosomes during protein synthesis. Beyond their essential function in translation, tRNAs also function in regulating gene expression, modulating ...
Hsiao-Yun Huang, Anita K. Hopper
doaj +1 more source
Transfer RNA genes experience exceptionally elevated mutation rates. [PDF]
, 2018 Transfer RNAs (tRNAs) are a central component for the biological synthesis of proteins, and they are among the most highly conserved and frequently transcribed genes in all living things.
Corbett-Detig, Russell B +5 more
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Molecular Simulations of the Ribosome and Associated Translation Factors
, 2014 The ribosome is a macromolecular complex which is responsible for protein synthesis in all living cells according to their transcribed genetic information.
Hamed H. Alsulami (532535) +3 more
core +6 more sources
N6-methyladenosine in mRNA disrupts tRNA selection and translation elongation dynamics
Nature Structural &Molecular Biology, 2016 N6-methylation of adenosine (forming m6A) is the most abundant post-transcriptional modification within the coding region of mRNA, but its role during translation remains unknown. Here, we used bulk kinetic and single-molecule methods to probe the effect
Junhong Choi +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.A multivalent aptamer corona is evolved via established ProteoFish‐SELEX (systematic evolution of ligands by exponential enrichment) for high‐throughput multiplexed detection of multiple cancers. Clinical validation using multivalent aptamer corona demonstrated high accuracy and specificity in multiplexed detection of ovarian, lung, and colorectal ...
Mengjie Wang +10 more
wiley +1 more source
Ribosomal Synthesis of Topologically Defined Thioisoindole‐Bridged Bicyclic Peptides
Angewandte Chemie, EarlyView.A flexible in vitro translation (FIT) system‐based strategy for ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is developed. The flexizyme substrate Ac‐Ala(NtBA)Sc‐CME is efficiently incorporated into FIT to generate ribosomal peptides bearing N‐terminal Ac‐Ala(NtBA)Sc as the cyclization handle, which after mild deprotection ...
Yue Zhang +3 more
wiley +2 more sources
Impact of tRNA Modifications and tRNA-Modifying Enzymes on Proteostasis and Human Disease
International Journal of Molecular Sciences, 2018 Transfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic information organized in mRNA codons, translating them into the code of 20 amino acids. To be fully active, tRNAs undergo extensive post-transcriptional modifications,
Marisa Pereira +5 more
semanticscholar +1 more source
Post-transcriptional regulation of the steady-state levels of mitochondrial tRNAs in HeLa cells [PDF]
, 1993 In human mitochondrial DNA (mtDNA), the tRNA genes are located in three different transcription units that are transcribed at three different rates. To analyze the regulation of tRNA formation by the three transcription units, we have examined the steady-
Attardi, Giuseppe, King, Michael P.
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