Results 141 to 150 of about 45,835 (226)

The role of tRNA-derived fragments in prostate cancer: a review

Cellular and Molecular Biology
Shakur, Babaei, Mehdi, Khorrami, Amirhossein, Eskandari, Masoomeh, Ramazani, Ali Akbar, Saffar Moghadam, Mostafa, Rezaei-Taviran, Shahrzad, Soleimani, Fatemeh, Ghadyani, , Sepehr Kahrizi, Abolfazl, Movafagh   +9 more
openaire   +2 more sources

The tRNA-derived fragment signature in lung cancer

Molecular Therapy - Oncolytics, 2022
openaire   +2 more sources

Unveiling isoleucyl‐tRNA synthetase 2 as a novel driver of breast cancer via β‐catenin pathway activation

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Isoleucyl‐tRNA synthetase 2 (IARS2) stabilizes β‐catenin by reducing its phosphorylation at Ser33/37/Thr41 and ubiquitin‐proteasome degradation, thereby promoting β‐catenin nuclear accumulation and transcriptional activation of downstream targets, including inhibitor of DNA binding 3, lactate dehydrogenase A, and Drosha ribonuclease III.
Xi Yang, Ya Wang, Yanjiao Yi, Yang Yang, Hongjiang Wang   +4 more
wiley   +1 more source

Differentially expressed tRNA-derived fragments in bovine fetuses with assisted reproduction induced congenital overgrowth syndrome. [PDF]

Front Genet, 2022
Goldkamp AK, Li Y, Rivera RM, Hagen DE.
europepmc   +1 more source

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song   +11 more
wiley   +1 more source

Expression profiles of tRNA-derived fragments and their potential roles in lung adenocarcinoma. [PDF]

Ann Transl Med, 2022
Huang LT, Cui M, Silva M, Okuda K, Shimada Y, Wang JH, Wang YB.   +6 more
europepmc   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

DUSP12 Regulates NAT10‐Mediated RNA Acetylation to Modulate DNA Repair and Therapeutic Response in Hepatocellular Carcinoma

MedComm, Volume 7, Issue 9, September 2026.
In hepatocellular carcinoma (HCC) cells exposed to doxorubicin, DUSP12 depletion maintains NAT10 phosphorylation, reducing its acetyltransferase activity, which leads to reduced ac4C RNA acetylation, DNA damage response, and DNA break repair, with consequent tumor sensitization.
Viktor Kalbermatter Boell, Diana Reis Della Corte Guimarães Pacheco, Yuli Thamires Magalhães, Laura Lima Turani, Isabeli Yumi Araújo Osawa, Nicolas Carlos Hoch, Fábio Luís Forti   +6 more
wiley   +1 more source

Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods. [PDF]

Mol Ther Nucleic Acids
Woudenberg T, van der Bent ML, van den Homberg DAL, Nguyen TTM, Wermer MJH, van den Wijngaard IR, Quax PHA, Nossent AY, Kruyt ND.   +8 more
europepmc   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source