Results 31 to 40 of about 110,116 (296)
Charging the code — tRNA modification complexes
Current Opinion in Structural Biology, 2019 All types of cellular RNAs are post-transcriptionally modified, constituting the so called 'epitranscriptome'. In particular, tRNAs and their anticodon stem loops represent major modification hotspots. The attachment of small chemical groups at the heart of the ribosomal decoding machinery can directly affect translational rates, reading frame ...
Rościsław Krutyhołowa +2 more
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tRNA modifications regulate translation during cellular stress [PDF]
FEBS Letters, 2014 The regulation of gene expression in response to stress is an essential cellular protection mechanism. Recent advances in tRNA modification analysis and genome‐based codon bias analytics have facilitated studies that lead to a novel model for translational control, with translation elongation dynamically regulated during stress responses.
Gu, Chen +2 more
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The biogenesis pathway of tRNA-derived piRNAs in Bombyx germ cells. [PDF]
, 2017 Transfer RNAs (tRNAs) function in translational machinery and further serves as a source of short non-coding RNAs (ncRNAs). tRNA-derived ncRNAs show differential expression profiles and play roles in many biological processes beyond translation ...
Honda, Shozo +5 more
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Multiple Layers of Stress-Induced Regulation in tRNA Biology
Life, 2016 tRNAs are the fundamental components of the translation machinery as they deliver amino acids to the ribosomes during protein synthesis. Beyond their essential function in translation, tRNAs also function in regulating gene expression, modulating ...
Hsiao-Yun Huang, Anita K. Hopper
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An engineered Tetrahymena tRNA(Gln) for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression [PDF]
, 1996 A new tRNA, THG73, has been designed and evaluated as a vehicle for incorporating unnatural amino acids site-specifically into proteins expressed in vivo using the stop codon suppression technique.
Abelson, John N. +7 more
core +1 more source
Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression [PDF]
, 2013 Mouse Ikbkap gene encodes IKAP—one of the core subunits of Elongator—and is thought to be involved in transcription. However, the biological function of IKAP, particularly within the context of an animal model, remains poorly characterized.
Falnes, Pål Ø. +4 more
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Functional Characterization of the Eukaryotic Cysteine Desulfurase Nfs1p from Saccharomyces cerevisiae [PDF]
, 2004 Previous studies have indicated that the essential protein Nfs1 performs a crucial role in cellular iron-sulfur (Fe/S) protein maturation. The protein is located predominantly in mitochondria, yet low amounts are present in cytosol and nucleus.
Balk +73 more
core +3 more sources
The subnuclear localization of tRNA ligase in yeast [PDF]
, 1987 Yeast tRNA ligase is an enzyme required for tRNA splicing. A study by indirect immune fluorescence shows that this enzyme is localized in the cell nucleus. At higher resolution, studies using indirect immune electron microscopy show this nuclear location
Abelson, John, Clark, Michael W.
core +1 more source
tRNA's modifications bring order to gene expression [PDF]
Current Opinion in Microbiology, 2008 The posttranscriptional modification of RNA is a significant investment in genes, enzymes, substrates, and energy. Advances in molecular genetics and structural biology indicate strongly that modifications of tRNA's anticodon domain control gene expression.
Estella M, Gustilo +2 more
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TrmL and TusA Are Necessary for rpoS and MiaA Is Required for hfq Expression in Escherichia coli
Biomolecules, 2017 Previous work demonstrated that efficient RNA Polymerase sigma S-subunit (RpoS) translation requires the N6-isopentenyladenosine i6A37 transfer RNA (tRNA) modification for UUX-Leu decoding.
Joseph I. Aubee +2 more
doaj +1 more source