Results 1 to 10 of about 55,541 (288)

Overview of tRNA Modifications in Chloroplasts [PDF]

Microorganisms, 2022
The chloroplast is a promising platform for biotechnological innovation due to its compact translation machinery. Nucleotide modifications within a minimal set of tRNAs modulate codon–anticodon interactions that are crucial for translation efficiency ...
Maxime Fages-Lartaud, Martin Frank Hohmann-Marriott   +1 more
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tRNA Modifications and Dysregulation: Implications for Brain Diseases [PDF]

Brain Sciences
Transfer RNAs (tRNAs) are well-known for their essential function in protein synthesis. Recent research has revealed a diverse range of chemical modifications that tRNAs undergo, which are crucial for various cellular processes.
Xinxin Lv, Ruorui Zhang, Shanshan Li, Xin Jin   +3 more
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Phytophthora capsici infection causes dynamic alterations in tRNA modifications and their associated gene candidates in black pepper [PDF]

Computational and Structural Biotechnology Journal, 2022
The efforts to signify the relevance of tRNA modifications were always within the limits of prokaryotes, humans, and some fewer model plant systems. The story of tRNA modifications in higher plants is still overlooked, especially in non-model spice crops.
Aswathi Usha, Divya Kattupalli, Pooja Viswam, Sruthi Bharathan, Eppurath Vasudevan Soniya   +4 more
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tRNA modifications: greasing the wheels of translation and beyond [PDF]

RNA Biology
Transfer RNA (tRNA) is one of the most abundant RNA types in cells, acting as an adaptor to bridge the genetic information in mRNAs with the amino acid sequence in proteins.
Minjie Zhang, Zhipeng Lu
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Genome-wide profiling of tRNA modifications by Induro-tRNAseq reveals coordinated changes [PDF]

Nature Communications
While all native tRNAs undergo extensive post-transcriptional modifications as a mechanism to regulate gene expression, mapping these modifications remains challenging.
Yuko Nakano, Howard Gamper, Henri McGuigan, Sunita Maharjan, Jiatong Li, Zhiyi Sun, Erbay Yigit, Sebastian Grünberg, Keerthana Krishnan, Nan-Sheng Li, Joseph A. Piccirilli, Ralph Kleiner, Nicole Nichols, Brian D. Gregory, Ya-Ming Hou   +14 more
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Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs [PDF]

Cell Reports
Summary: The tRNA methyltransferase 1 (TRMT1) enzyme catalyzes the N2,N2-dimethylguanosine (m2,2G) modification in tRNAs. Intriguingly, vertebrates encode an additional tRNA methyltransferase 1-like (TRMT1L) paralog.
Kejia Zhang, Aidan C. Manning, Jenna M. Lentini, Jonathan Howard, Felix Dalwigk, Reza Maroofian, Stephanie Efthymiou, Patricia Chan, Sergei I. Eliseev, Zi Yang, Hayley Chang, Ehsan Ghayoor Karimiani, Behnoosh Bakhshoodeh, Henry Houlden, Stefanie M. Kaiser, Todd M. Lowe, Dragony Fu   +16 more
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Hypoxia induces alterations in tRNA modifications involved in translational control [PDF]

BMC Biology, 2023
Background Adaptation to high-altitude hypobaric hypoxia has been shown to require a set of physiological traits enabled by an associated set of genetic modifications, as well as transcriptome regulation.
Huanping Guo, Lin Xia, Wei Wang, Wei Xu, Xipeng Shen, Xiao Wu, Tong He, Xuelin Jiang, Yinying Xu, Pan Zhao, Dongmei Tan, Xi Zhang, Yunfang Zhang   +12 more
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Translational regulation by oxidative desulfuration of tRNA modifications [PDF]

Nature Communications
Modifications in the anticodon region of transfer RNA (tRNA) are essential for accurate and efficient protein synthesis. 5-Methyl-2-thiouridine derivatives (xm5s2U) are major modifications at the wobble position of tRNA anticodons decoding purine-ending ...
Yufeng Mo, Kensuke Ishiguro, Kenjyo Miyauchi, Yuriko Sakaguchi, Yosei Hanzawa, Naho Akiyama, Ayaka Murayama, Kodai Machida, Hiroaki Imataka, Akio Yamashita, Takayuki Ohira, Mikako Shirouzu, Tsutomu Suzuki   +12 more
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tRNA modifications as regulators of bacterial virulence and stress responses. [PDF]

PLoS Pathogens
Bacteria are recognized for their ability to adapt their lifestyle to the environment. Specifically, when considering pathogenic bacteria, their capacity to respond to stress and switch to a virulent state through gene regulation is crucial.
Chloé Teixeira, François Vandenesch, Karen Moreau   +2 more
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Regulatory Factors for tRNA Modifications in Extreme- Thermophilic Bacterium Thermus thermophilus [PDF]

Frontiers in Genetics, 2019
Thermus thermophilus is an extreme-thermophilic bacterium that can grow at a wide range of temperatures (50–83°C). To enable T. thermophilus to grow at high temperatures, several biomolecules including tRNA and tRNA modification enzymes show extreme heat-
Hiroyuki Hori
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