Results 11 to 20 of about 55,541 (288)

Genome recoding by tRNA modifications [PDF]

Open Biology, 2016
RNA modifications are emerging as an additional regulatory layer on top of the primary RNA sequence. These modifications are particularly enriched in tRNAs where they can regulate not only global protein translation, but also protein translation at the ...
Francesca Tuorto, Frank Lyko
doaj   +3 more sources

m1A Post‐Transcriptional Modification in tRNAs [PDF]

Biomolecules, 2017
To date, about 90 post‐transcriptional modifications have been reported in tRNA expanding their chemical and functional diversity. Methylation is the most frequent post‐transcriptional tRNA modification that can occur on almost all nitrogen sites of
Stephanie Oerum, Clément Dégut, Pierre Barraud, Carine Tisné   +3 more
doaj   +3 more sources

MoDorado: enhanced detection of tRNA modifications in nanopore sequencing by off-label use of modification callers. [PDF]

Nucleic Acids Res
Rübsam FNM, Liu-Wei W, Sun Y, Patel BI, van der Toorn W, Piechotta M, Dieterich C, Kleist MV, Ehrenhofer-Murray AE.   +8 more
europepmc   +3 more sources

Biosynthesis and functions of sulfur modifications in tRNA [PDF]

Frontiers in Genetics, 2014
Sulfur is an essential element for a variety of cellular constituents in all living organisms. In tRNA molecules, there are many sulfur-containing nucleosides, such as the derivatives of 2‑thiouridine (s2U), 4-thiouridine (s4U), 2-thiocytidine (s2C), and
Naoki eShigi
doaj   +3 more sources

Mitochondrial tRNA modifications: functions, diseases caused by their loss, and treatment strategies. [PDF]

RNA
Chujo T, Tomizawa K.
europepmc   +3 more sources

Temperature-Dependent tRNA Modifications in Bacillales. [PDF]

Int J Mol Sci
Transfer RNA (tRNA) modifications are essential for the temperature adaptation of thermophilic and psychrophilic organisms, as they control the rigidity and flexibility of transcripts. To further understand how specific tRNA modifications are adjusted to maintain functionality in response to temperature fluctuations, we investigated whether tRNA ...
Hoffmann A, Lorenz C, Fallmann J, Wolff P, Lechner A, Betat H, Mörl M, Stadler PF.   +7 more
europepmc   +4 more sources

The impact of tRNA modifications on translation in cancer: identifying novel therapeutic avenues. [PDF]

NAR Cancer
Añazco-Guenkova AM, Miguel-López B, Monteagudo-García Ó, García-Vílchez R, Blanco S.   +4 more
europepmc   +3 more sources

Making Sense of "Nonsense" and More: Challenges and Opportunities in the Genetic Code Expansion, in the World of tRNA Modifications. [PDF]

Int J Mol Sci, 2022
Lateef OM, Akintubosun MO, Olaoba OT, Samson SO, Adamczyk M.   +4 more
europepmc   +3 more sources

Autophosphorylation of conserved yeast and human casein kinase 1 isozymes regulates Elongator-dependent tRNA modifications. [PDF]

Nucleic Acids Res
Landrock MF, Krutyhołowa R, Böhnert P, Mazur J, Honc M, Hammermeister A, Bessler L, Scherf D, Elms A, Radczuk N, Skupien-Rabian B, Jankowska U, Herberg FW, Helm M, Klassen R, Glatt S, Schaffrath R.   +16 more
europepmc   +3 more sources

7-Methylguanosine Modifications in Transfer RNA (tRNA) [PDF]

International Journal of Molecular Sciences, 2018
More than 90 different modified nucleosides have been identified in tRNA. Among the tRNA modifications, the 7-methylguanosine (m7G) modification is found widely in eubacteria, eukaryotes, and a few archaea. In most cases, the m7G modification occurs at position 46 in the variable region and is a product of tRNA (m7G46) methyltransferase.
Chie Tomikawa
openalex   +4 more sources