Results 21 to 30 of about 55,541 (288)
A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth
eLife, 2023 Diverse chemical modifications fine-tune the function and metabolism of tRNA. Although tRNA modification is universal in all kingdoms of life, profiles of modifications, their functions, and physiological roles have not been elucidated in most organisms ...
Francesca G Tomasi +3 more
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Extracurricular Functions of tRNA Modifications in Microorganisms. [PDF]
Genes (Basel), 2020 Transfer RNAs (tRNAs) are essential adaptors that mediate translation of the genetic code. These molecules undergo a variety of post-transcriptional modifications, which expand their chemical reactivity while influencing their structure, stability, and functionality.
Edwards AM, Addo MA, Dos Santos PC.
europepmc +4 more sources
Unravelling Strain-Specific Modifications of Toxoplasma gondii tRNA and sncRNA Using LC-MS/MS
Microbiology Spectrum, 2023 Many RNA modifications have been detected in rRNA, tRNA and small noncoding RNA (sncRNA) as well as in low-abundance RNA species such mRNA. Although RNA modifications play roles in many cellular and biological processes in various domains of life ...
Wei Wang +8 more
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Disruption to tRNA Modification by Queuine Contributes to Inflammatory Bowel DiseaseSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Backgrounds and Aims: Transfer RNA (tRNA) is the most extensively modified RNA in cells. Queuosine modification is a fundamental process for ensuring the fidelity and efficiency of translation from RNA to protein.
Jilei Zhang +5 more
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Loss of a Conserved tRNA Anticodon Modification Perturbs Plant Immunity. [PDF]
PLoS Genetics, 2015 tRNA is the most highly modified class of RNA species, and modifications are found in tRNAs from all organisms that have been examined. Despite their vastly different chemical structures and their presence in different tRNAs, occurring in different ...
Vicente Ramírez +8 more
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The host tRNA epitranscriptome: A new player in RNA virus infections
Frontiers in Virology, 2022 Viruses completely depend on the host translation machineries to express the viral proteins. Recent data reveal an unprecedented interaction of positive strand RNA ((+)RNA) viruses with the host tRNA epitranscriptome to favor viral protein expression via
Marc Talló-Parra +2 more
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tRNA wobble modifications and protein homeostasis [PDF]
Translation, 2016 tRNA is a central component of the protein synthesis machinery in the cell. In living cells, tRNAs undergo numerous post-transcriptional modifications. In particular, modifications at the anticodon loop play an important role in ensuring efficient protein synthesis, maintaining protein homeostasis, and helping cell adaptation and survival.
Ranjan, N., Rodnina, M.
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A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. [PDF]
PLoS Genetics, 2010 Decades of study have revealed more than 100 ribonucleoside structures incorporated as post-transcriptional modifications mainly in tRNA and rRNA, yet the larger functional dynamics of this conserved system are unclear. To this end, we developed a highly
Clement T Y Chan +5 more
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Neural Regeneration Research, 2020 Over the past decades, tRNA was found to be a rich hub of RNA modifications such as 1-methyladenosine and 5-methycytosine modifications and others, holding more than half of all modifications occurring in RNA molecules.
Sherif Rashad +2 more
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Prediction of uridine modifications in tRNA sequences [PDF]
BMC Bioinformatics, 2014 In past number of methods have been developed for predicting post-translational modifications in proteins. In contrast, limited attempt has been made to understand post-transcriptional modifications. Recently it has been shown that tRNA modifications play direct role in the genome structure and codon usage.
Panwar, Bharat, Raghava, Gajendra PS
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