Results 91 to 100 of about 15,306 (209)

Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells

Nature Communications, 2019
Trophectoderm lineage development is essential for implantation, placentation, and healthy pregnancy. Here the authors map super-enhancers (SEs) in trophoblast stem cells and find both TE-specific master regulators and 150 previous uncharacterised ...
Bum-Kyu Lee, Yu jin Jang, Mijeong Kim, Lucy LeBlanc, Catherine Rhee, Jiwoon Lee, Samuel Beck, Wenwen Shen, Jonghwan Kim   +8 more
doaj   +1 more source

Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation

, 2022
STUDY QUESTION: How does the human embryo breach the endometrial epithelium at implantation? SUMMARY ANSWER: Embryo attachment to the endometrial epithelium promotes the formation of multinuclear syncytiotrophoblast from trophectoderm, which goes on to ...
Kimber, Susan J; id_orcid, Stevens, Adam; id_orcid, Aplin, John D; id_orcid, Westwood, Melissa; id_orcid, Kimber, Susan J, Stevens, Adam, Brison, Daniel R, Aplin, John D, Garner, Terence, Parsons, Lydia, Babbington, Phoebe A, Wangsaputra, Ivan, Ruane, Peter T, Westwood, Melissa, Ruane, Peter T; id_orcid, Terence Garner, Ivan Wangsaputra, John D Aplin, Susan J Kimber, Lydia Parsons, Adam Stevens, Melissa Westwood, Daniel R Brison, Peter T Ruane, Phoebe A Babbington   +24 more
core   +1 more source

Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo

, 2008
The first lineage decision during mouse development is the establishment of trophectoderm and inner cell mass lineages, morphologically distinguishable at the blastocyst stage. The Caudal-like transcription factor Cdx2 is required for repression of inner
Ralston, Amy, Rossant, Janet
core   +1 more source

Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm

, 2006
During mammalian embryogenesis the trophectoderm represents the first epithelial structure formed. The cell adhesion molecule E-cadherin is ultimately necessary for the transition from compacted morula to the formation of the blastocyst to ensure correct
Stemmler, M P, Kemler, R, B. Kanzler, Stemmler, M., de Vries, W., Dominis, M, N. G. Kan, Junghans, D., Kan, N G, R. Kemler, Kanzler, B, Kemler, R., Kan, N., Junghans, D, de, Vries W, M. P. Stemmler, W. N. de Vries, Kanzler, B., D. Junghans, M. Dominis, Dominis, M.   +20 more
core   +1 more source

Trophectoderm biopsy—perhaps not such a benign intervention [PDF]

Fertility and Sterility, 2020
Catherine E, Gordon, Catherine, Racowsky
openaire   +2 more sources

Generation of Cdx2-mCherry knock-in murine ES cell line to model trophectoderm and intestinal lineage differentiation

Stem Cell Research, 2019
Caudal-type homeobox 2 (.Cdx2) transcription factor is an essential regulator of differentiation to the intestinal epithelium, somatic mesoderm and trophectoderm function in the mouse.
Debabrata Jana, Hanuman T. Kale, P. Chandra Shekar   +2 more
doaj   +1 more source

64 USING PORCINE GRANULOSA CELLS AS FEEDERS FOR PORCINE AND BOVINE TROPHECTODERM CELL CULTURE

, 2012
The trophectoderm cells, arising from the outer side of the blastomere in the blastocyst stage, are the first differentiated embryonic cells with specific potential as stem cells.
A. Elsayed, S. J. Kim, J. T. Kang, B. C. Lee, G. Jang, S. J. Park, I. M. Saadeldin, J. H. Moon   +7 more
core   +1 more source

Spatial dynamics of mTOR pathway activity during bovine embryo development

Frontiers in Cell and Developmental Biology
The mTOR pathway regulates cell proliferation, growth, survival, and metabolism by integrating nutritional and growth factor signaling. In embryos, its activity is influenced by the availability of nutrients in the culture medium, and it can affect the ...
Francieli P. Berling, Viviane B. G. Bacaro, Ricardo I. de Paschoal, Marcella P. Milazzotto, Marcelo D. Goissis   +4 more
doaj   +1 more source

Transition from blastomere to trophectoderm biopsy: comparing two preimplantation genetic testing for aneuploidies strategies

, 2018
SummaryShortly after the implementation of comprehensive chromosome screening (CCS) techniques for preimplantation genetic testing for aneuploidies (PGT-A), the discussion about the transition from day 3 to blastocyst stage biopsy was initiated ...
Bonaventura Coroleu, Lluc Coll, Marta Devesa, Anna Veiga, Montserrat Boada, Mònica Parriego, Gemma Arroyo, Francesca Vidal, Ignacio Rodríguez   +8 more
core   +1 more source

Detecting mosaicism in trophectoderm biopsies [PDF]

Human Reproduction, 2017
Sermon, Karen D, Spits, Claudia, Mertzanidou, Afroditi, Vermeesch, Joris R, Fiorentino, Francesco   +4 more
openaire   +3 more sources