Results 61 to 70 of about 87,349 (342)

Alteration of Pituitary Tumor Transforming Gene-1 Regulates Trophoblast Invasion via the Integrin/Rho-Family Signaling Pathway. [PDF]

PLoS ONE, 2016
Trophoblast invasion ability is an important factor in early implantation and placental development. Recently, pituitary tumor transforming gene 1 (PTTG1) was shown to be involved in invasion and proliferation of cancer.
Seung Mook Lim, Hee Yeon Jang, Ji Eun Lee, Joong Sik Shin, Sun-Hwa Park, Bo Hyun Yoon, Gi Jin Kim   +6 more
doaj   +1 more source

Autophagy suppression of trophoblast cells induces pregnancy loss by activating decidual NK cytotoxicity and inhibiting trophoblast invasion

Cell Communication and Signaling, 2020
Background The crosstalk between trophoblast cells and decidual NK cells plays an important role in the establishment and maintenance of normal pregnancy. Recent studies reported that autophagy can induce immune tolerance at the maternal fetal interface,
Haifang Tan, Shao-Liang Yang, Ming-qing Li, Hai-Yan Wang   +3 more
semanticscholar   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast

Stem Cell Reports, 2016
Controversy surrounds reports describing the derivation of human trophoblast cells from placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers that define cells as belonging to the trophoblast lineage.
Cheryl Q.E. Lee, Lucy Gardner, Margherita Turco, Nancy Zhao, Matthew J. Murray, Nicholas Coleman, Janet Rossant, Myriam Hemberger, Ashley Moffett   +8 more
doaj   +1 more source

BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion

eLife, 2021
Normal function of the placenta depends on the earliest developmental stages when trophoblast cells differentiate and invade into the endometrium to establish the definitive maternal-fetal interface.
Vicente Perez-Garcia, Georgia Lea, Pablo Lopez-Jimenez, Hanneke Okkenhaug, Graham J Burton, Ashley Moffett, Margherita Y Turco, Myriam Hemberger   +7 more
doaj   +1 more source

Per- and polyfluoroalkyl substances (PFAS) differentially inhibit placental trophoblast migration and invasion in vitro.

Toxicological Sciences, 2020
Per- and polyfluoroalkyl substances (PFAS)are used as industrial surfactants and chemical coatings for household goods such as Teflon. Despite regulatory efforts to phase out legacy PFAS, they remain detectable in drinking water throughout the United ...
John T. Szilagyi, Anastasia N Freedman, Stewart Kepper, Arjun M Keshava, Jacqueline Bangma, Rebecca C Fry   +5 more
semanticscholar   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Preeclampsia: The Relationship between Uterine Artery Blood Flow and Trophoblast Function

International Journal of Molecular Sciences, 2019
Maternal uterine artery blood flow is critical to maintaining the intrauterine environment, permitting normal placental function, and supporting fetal growth. It has long been believed that inadequate transformation of the maternal uterine vasculature is
A. Ridder, V. Giorgione, A. Khalil, B. Thilaganathan   +3 more
semanticscholar   +1 more source

Trophoblast‐secreted soluble‐PD‐L1 modulates macrophage polarization and function

Journal of Leukocyte Biology, 2020
Decidual macrophages are in close contact with trophoblast cells during placenta development, and an appropriate crosstalk between these cellular compartments is crucial for the establishment and maintenance of a healthy pregnancy.
Yong‐Hong Zhang, P. Aldo, Y. You, Jiahui Ding, J. Kaislasuo, J. Petersen, E. Lokkegaard, Gang Peng, M. Paidas, S. Simpson, L. Pal, S. Guller, Hong Liu, A. Liao, G. Mor   +14 more
semanticscholar   +1 more source

Highly Tunable and Cell‐Remodelable Thiol‐ene Alginate‐Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication

Advanced Healthcare Materials, EarlyView.
Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez, Adrián Seijas‐Gamardo, Antonio J. Feliciano, Panagiota Kakni, Anna M. Kip, Paul Wieringa, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni   +8 more
wiley   +1 more source