Results 61 to 70 of about 109,495 (390)
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Reproductive success in placental mammals relies on proper development of the trophoblast lineage. In particular, a proper balance in self-renewal vs. differentiation of trophoblast progenitors is critical for establishment of pregnancy.
Biswarup Saha +10 more
semanticscholar +1 more source
A generalized linear model for decomposing cis-regulatory, parent-of-origin, and maternal effects on allele-specific gene expression [PDF]
, 2017 Joint quantification of genetic and epigenetic effects on gene expression is important for understanding the establishment of complex gene regulation systems in living organisms. In particular, genomic imprinting and maternal effects play important roles in the developmental process of mammals and flowering plants.
arxiv +1 more source
Spatiotemporal Expression of Pregnancy-Specific Glycoprotein Gene rnCGMl in Rat Placenta [PDF]
, 1993 As a basis towards a better understanding of the role of the pregnancy-specific glycoprotein (PSG) family in the maintenance of pregnancy, detailed investigations are described on the expression of a recently identified rat PSG gene (rnCGM1) at the mRNA ...
Lucas, Kurt +4 more
core +1 more source
Cell Communication and Signaling, 2020 Background The crosstalk between trophoblast cells and decidual NK cells plays an important role in the establishment and maintenance of normal pregnancy. Recent studies reported that autophagy can induce immune tolerance at the maternal fetal interface,
Haifang Tan +3 more
semanticscholar +1 more source
Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions. [PDF]
, 2005 Objective— Invasion of uterine spiral arteries by extravillous trophoblasts in the first trimester of pregnancy results in loss of endothelial and musculoelastic layers.
Ashton, SV +6 more
core +1 more source
Cell Discovery, 2020 N1-methyladenosine (m1A) is one of the important post-transcriptional modifications in RNA and plays an important role in promoting translation or decay of m1A-methylated messenger RNA (mRNA), but the “reader” protein and the exact biological role of m1A
Qingliang Zheng +6 more
semanticscholar +1 more source
Alteration of Pituitary Tumor Transforming Gene-1 Regulates Trophoblast Invasion via the Integrin/Rho-Family Signaling Pathway. [PDF]
PLoS ONE, 2016 Trophoblast invasion ability is an important factor in early implantation and placental development. Recently, pituitary tumor transforming gene 1 (PTTG1) was shown to be involved in invasion and proliferation of cancer.
Seung Mook Lim +6 more
doaj +1 more source
(Dis)similarities between the Decidual and Tumor Microenvironment
Biomedicines, 2022 Placenta-specific trophoblast and tumor cells exhibit many common characteristics. Trophoblast cells invade maternal tissues while being tolerated by the maternal immune system.
Jelena Krstic +12 more
doaj +1 more source
Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. [PDF]
, 1989 Human fetal development depends on the embryo rapidly gaining access to the maternal circulation. The trophoblast cells that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain tumor-like properties ...
Cui, TY +7 more
core +3 more sources
Trophoblast‐secreted soluble‐PD‐L1 modulates macrophage polarization and function
Journal of Leukocyte Biology, 2020 Decidual macrophages are in close contact with trophoblast cells during placenta development, and an appropriate crosstalk between these cellular compartments is crucial for the establishment and maintenance of a healthy pregnancy.
Yong‐Hong Zhang +14 more
semanticscholar +1 more source