Results 71 to 80 of about 109,495 (390)

Obesogenic Diet in Mice Leads to Inflammation and Oxidative Stress in the Mother in Association with Sex-Specific Changes in Fetal Development, Inflammatory Markers and Placental Transcriptome

Antioxidants
Background: Obesity during pregnancy is related to adverse maternal and neonatal outcomes. Factors involved in these outcomes may include increased maternal insulin resistance, inflammation, oxidative stress, and nutrient mishandling. The placenta is the
Alejandro A. Candia, Samantha C. Lean, Cindy X. W. Zhang, Daniel R. McKeating, Anna Cochrane, Edina Gulacsi, Emilio A. Herrera, Bernardo J. Krause, Amanda N. Sferruzzi-Perri   +8 more
doaj   +1 more source

Single-Cell Analysis Identifies Thymic Maturation Delay in Growth-Restricted Neonatal Mice

Frontiers in Immunology, 2018
Fetal growth restriction (FGR) causes a wide variety of defects in the neonate which can lead to increased risk of heart disease, diabetes, anxiety and other disorders later in life.
Wendi A. Bacon, Wendi A. Bacon, Wendi A. Bacon, Russell S. Hamilton, Russell S. Hamilton, Ziyi Yu, Jens Kieckbusch, Jens Kieckbusch, Delia Hawkes, Ada M. Krzak, Chris Abell, Francesco Colucci, Francesco Colucci, D. Stephen Charnock-Jones, D. Stephen Charnock-Jones   +14 more
doaj   +1 more source

Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function. [PDF]

, 2014
STUDY QUESTION Are the concentrations of factors secreted by decidual natural killer (dNK) cells from pregnancies at high risk of poor spiral artery remodelling different to those secreted from pregnancies at low risk?
A. E. Wallace, A. P. Johnstone, Athanassiades, Cartwright, Choy, Desai, Engert, Fraser, Furuya, G. S. Whitley, Hanna, J. E. Cartwright, Karamouzis, Kim, King, King, Koga, Meekins, Melchiorre, Moroianu, Nasu, Pijnenborg, Pijnenborg, Pollheimer, Prefumo, Prefumo, R. Fraser, Rehn, S. Gurung, S. S. Goulwara, Santoni, Treiber-Held, van der Harten, Verma, Wei, Zhou   +35 more
core   +1 more source

Per- and polyfluoroalkyl substances (PFAS) differentially inhibit placental trophoblast migration and invasion in vitro.

Toxicological Sciences, 2020
Per- and polyfluoroalkyl substances (PFAS)are used as industrial surfactants and chemical coatings for household goods such as Teflon. Despite regulatory efforts to phase out legacy PFAS, they remain detectable in drinking water throughout the United ...
John T. Szilagyi, Anastasia N Freedman, Stewart Kepper, Arjun M Keshava, Jacqueline Bangma, Rebecca C Fry   +5 more
semanticscholar   +1 more source

Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism

iScience, 2023
Summary: Placental hormones orchestrate maternal metabolic adaptations to support pregnancy. We hypothesized that placental ER stress, which characterizes early-onset pre-eclampsia (ePE), compromises glycosylation, reducing hormone bioactivity and these ...
Hong Wa Yung, Xiaohui Zhao, Luke Glover, Charlotte Burrin, Poh-Choo Pang, Carolyn J.P. Jones, Carolyn Gill, Kate Duhig, Matts Olovsson, Lucy C. Chappell, Stuart M. Haslam, Anne Dell, Graham J. Burton, D. Stephen Charnock-Jones   +13 more
doaj  

Expression of CD82 in human trophoblast and its role in trophoblast invasion. [PDF]

PLoS ONE, 2012
BACKGROUND: Well-controlled trophoblast invasion at maternal-fetal interface is a critical event for the normal development of placenta. CD82 is a member of transmembrane 4 superfamily, which showed important role in inhibiting tumor cell invasion and ...
Qian Zhang, Dongmei Tan, Wenping Luo, Junjie Lu, Yi Tan   +4 more
doaj   +1 more source

The platelet-derived growth factor receptor alpha promoter-directed expression of cre recombinase in mouse placenta. [PDF]

, 2019
BackgroundNumerous pathologies of pregnancy originate from placental dysfunction. It is essential to understand the functions of key genes in the placenta in order to discern the etiology of placental pathologies.
Lee, Samuel, Natale, David Renato Christopher, Qiao, Liping, Shao, Jianhua, Wattez, Jean-Sebastien   +4 more
core   +1 more source

Replenishing co‐downregulated miR‐100‐5p and miR‐125b‐5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption

Molecular Oncology, Volume 19, Issue 4, Page 1203-1228, April 2025.
MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso, Shivani Bailey, Luz Alonso‐Crisostomo, Dawn Ward, Christos Panayi, Zachary G. L. Scurlock, Harpreet K. Saini, Stephen P. Smith, James C. Nicholson, Anton J. Enright, Cinzia G. Scarpini, Nicholas Coleman, Matthew J. Murray   +12 more
wiley   +1 more source

Impaired decidual natural killer cell regulation of vascular remodelling in early human pregnancies with high uterine artery resistance [PDF]

, 2012
During human pregnancy, natural killer (NK) cells accumulate in the maternal decidua, but their specific roles remain to be determined. Decidual NK (dNK) cells are present during trophoblast invasion and uterine spiral artery remodelling.
Cartwright, JE, Fraser, R, Host, AJ, Johnstone, AP, Sebire, NJ, Thilaganathan, B, Whitley, GS   +6 more
core   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source