Practice‐Changing Advances in Systemic Therapies Shaping the Landscape of Lung Cancer in 2025
Cancer Innovation, Volume 5, Issue 3, June 2026.This review synthesizes 2025 breakthroughs in systemic therapies of lung cancer, especially in targeted and immunotherapies, accelerating mortality decline across non‐small cell lung cancer and small cell lung cancer stages. ABSTRACT With the rapid advancement of molecular profiling and precision therapeutics, targeted and immunotherapeutic strategies ...
Zhenyu Zhou +3 more
wiley +1 more source
Role of ferroptosis-related GPX4 signaling in the fusion of human trophoblast cells. [PDF]
Sci RepYoshida K +6 more
europepmc +1 more source
Treatment Advances in Gynecologic Cancers: Insights From Recent Clinical Trials
Cancer Innovation, Volume 5, Issue 3, June 2026.Overview of immunotherapy and antibody‐drug conjugates, and their mechanism against cancer. (The Graphical Abstract Image was created with BioRender.) ABSTRACT Gynecologic cancers remain a major global health burden for women. Their management has evolved toward a gynecologic oncologist‐led multimodal paradigm.
Yiyang Shen +6 more
wiley +1 more source
In Vitro 3D Model of Human Endometrial Stromal and Trophoblast Cells: Techniques for an Optimized Formation and Cryopreservation of Spheroids. [PDF]
Methods ProtocMuthuraj K +5 more
europepmc +1 more source
Cancer, Volume 132, Issue S1, 1 June 2026.Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho +3 more
wiley +1 more source
Mechanisms of oxygen sensing in human trophoblast cells
, 2004 Early placentation occurs in a relatively hypoxic environment. As placentation progresses, the events associated with trophoblast differentiation in response to increasing oxygen are known; however, the mechanisms by which trophoblast cells 'sense' the ...
De Marco, Carla Saveria
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Epigenetic Perspectives on Maternal Gut Microbiota's Impact on Embryonic and Fetal Development
Comprehensive Physiology, Volume 16, Issue 3, June 2026.This review summarizes how maternal health and nutrition shape gut microbiota via epigenetics to regulate embryonic development. It highlights microbiota‐embryo interactions, disruption by prenatal chemical exposures, and personalized nutrition for disease prevention, offering novel insights and therapeutic targets.
Shoulong Xu +6 more
wiley +1 more source
Vascular endothelial growth factor is a chemoattractant for trophoblast cells
A role for angiogenic growth factors in trophoblast invasion has been postulated. Directional motility (chemotaxis) is an important function of trophoblast cells.
Lash GE +3 more
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Disruption of the Placenta-Brain Axis in Transgenic Mice Lacking Serotonin Transporter (SERT) in Trophoblast Cells. [PDF]
Int J Mol SciEllenberger DT +10 more
europepmc +1 more source
Comprehensive Physiology, Volume 16, Issue 3, June 2026.miR‐21‐5p protects embryonic growth and heart function during developmental hypoxia by dampening HIF responses and shifting gene networks toward improved cardiomyocyte survival and calcium handling. This work identifies miR‐21‐5p as a promising therapeutic target for preventing fetal growth restriction and cardiovascular impairment in high‐risk ...
Bernardo J. Krause +12 more
wiley +1 more source