Results 211 to 220 of about 51,707 (295)

Rosiglitazone-Mediated Activation of PPARγ Induces PlGF Expression in Trophoblast Cells. [PDF]

Reprod Sci
Nandi P, Halari C, Lee M, Prabaharan E, Sarajideen S, Lee DK, Drewlo S.   +6 more
europepmc   +1 more source

Challenges in Implementing Revocation of Oncology Drugs Under Conditional Early Approval in Japan: Regulatory Insights From Comparisons With FDA/EMA

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Expedited pathways in the United States (U.S.), European Union (EU), and Japan (JP) enable earlier access to innovative therapies for rare and serious diseases. In 2025, Japan explicitly introduced revocation provisions to its Conditional Early Approval (CEA).
Takahiro Handa, Arata Tanaka, Mayumi Shikano, Rika Wakao   +3 more
wiley   +1 more source

Tanshinone IIA induces oxidative stress in trophoblast cells and enhances copper dependent death. [PDF]

Sci Rep
Du J, Wang X, Zeng Y, Feng J, Yang L, Huang Y, Deng G.   +6 more
europepmc   +1 more source

Comprehensive Genomic Characterization Between Urothelial Carcinoma Subtypes/Divergent Differentiation (S/DD) and Pure Urothelial Carcinoma Using a Large‐Scale Japanese Genomic Panel Dataset

International Journal of Urology, Volume 33, Issue 6, June 2026.
ABSTRACT Objectives Urothelial carcinoma (UC) is a common malignancy; however, UC subtypes/divergent differentiation (S/DD) accounts for only 10%–20% of overall cases. S/DD's aggressive biological behavior significantly affects its prognosis and therapeutic decision‐making; thus, elucidating its genomic landscape within UC is important.
Go Kobayashi, Yohei Sekino, Shunsuke Miyamoto, Kohei Kobatake, Hiroyuki Kitano, Keisuke Goto, Akihiro Goriki, Keisuke Hieda, Testutaro Hayashi, Kazuhiro Sentani, Nobuyuki Hinata   +10 more
wiley   +1 more source

Normalization of trophoblast mTOR signaling rescues impaired function in primary human trophoblast cells isolated from pregnancies complicated by fetal growth restriction. [PDF]

Cell Death Discov
Francis EC, Shimada H, Powell TL, Boyle KE, Dabelea D, Jansson T, Rosario FJ.   +6 more
europepmc   +1 more source

Immunomodulatory Role of Natural Progesterone in Pregnancy: A Review

Journal of Obstetrics and Gynaecology Research, Volume 52, Issue 6, June 2026.
ABSTRACT Aim Pregnancy complications such as miscarriage, preterm birth (PTB), and luteal phase defects (LPD) are significant reproductive health issues globally, with both physical and psychological implications. This review aims to examine the role of natural progesterone in pregnancy‐related disorders, specifically threatened and recurrent ...
Prakash Mehta, Hemant Deshpande, Anjali Deshpande, Reshma Quadros, Shruti Dharmadhikari, Chintan Khandhedia, Gaurav Puppalwar, Amey Mane, Suyog Mehta   +8 more
wiley   +1 more source

JEG-3 Trophoblast Cells Influence ILC-like Transformation of NK Cells In Vitro. [PDF]

Int J Mol Sci
Mikhailova V, Grebenkina P, Selkov S, Sokolov D.   +3 more
europepmc   +1 more source

ESM‐1 and GBP‐1 are associated with endothelial dysfunction: emerging biomarkers or key players in the pathophysiology of preeclampsia?

The Journal of Physiology, Volume 604, Issue 11, Page 4482-4496, 1 June 2026.
Abstract figure legend Endothelial specific molecule‐1 (ESM‐1) and guanylate binding protein‐1 (GBP‐1) are proteins that are produced by activated/dysfunctional endothelial cells and are increased and decreased, respectively, during preeclampsia. It remains to be established whether ESM‐1 and GBP‐1 could potentially be included as biomarkers for the ...
Ines Pronk, Joost H. N. Schuitemaker, Marijke M. Faas, Alexandra M. Smink   +3 more
wiley   +1 more source

Chorionic trophoblast cells demonstrate functionally different phenotypes from placental trophoblasts†. [PDF]

Biol Reprod
Choudhury J, Richardson LS, Urrabaz-Garza R, Jacob J, Kammala AK, Menon R.   +5 more
europepmc   +1 more source

Excessive hypercholesterolaemia during pregnancy as a risk factor for endothelial dysfunction in pre‐eclampsia

The Journal of Physiology, Volume 604, Issue 11, Page 4302-4317, 1 June 2026.
Abstract figure legend Excessive hypercholesterolaemia during pregnancy impairs maternal endothelial function, which, in turn, drives the development of pre‐eclampsia and may also contribute to the increased risk of later‐life cardiovascular disease in women.
Amanda A. de Oliveira, Floor Spaans, Christy‐Lynn M. Cooke, Sandra T. Davidge   +3 more
wiley   +1 more source