Results 81 to 90 of about 51,707 (295)

NK Cells and Trophoblasts [PDF]

The Journal of Experimental Medicine, 2004
In placental mammals, viviparity—the production of living young within the mother's body—evolved under the auspices of the immune system. Elements of immunity were incorporated, giving pregnancy a mildly inflammatory character. Formation of the placenta, the organ that feeds the fetus, involves a cooperation between maternal natural killer (NK) cells ...
openaire   +1 more source

Radial capacity and hemodynamics evaluation in vitro and implantable feasibility validation in vivo of thinner bioresorbable polymer vascular stents

BMEMat, EarlyView.
A series of in vitro experiments, numerical simulations and in vivo experiments were conducted to jointly evaluate the effects of different thicknesses of bioabsorbable polymer vascular stents on their radial capacity, hemodynamics and in vivo outcomes.
Chong Chen, Tao Li, Zhongyou Li, Jingyuan Zhou, Zhuo Zhang, Yan Xiong, Rifang Luo, Yu Chen, Yunbing Wang, Ping Fu   +9 more
wiley   +1 more source

Placental crises: disruptive selection and maternal under‐investment as the foundations of mammalian placental evolution and dysfunction

Biological Reviews, EarlyView.
ABSTRACT Among the vertebrates, mammals are notable for the dominance of live birth and placental nutrition. The structural diversity of the mammalian placenta is remarkable, despite sharing a single common ancestor and conserved physiological functions.
Davis Laundon, Neil J. Gostling, Ian G. Reddin, Bram G. Sengers, Pascale Chavatte‐Palmer, Rohan M. Lewis   +5 more
wiley   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Impact of donor mare and stallion identity on the likelihood of pregnancy after transfer of in vitro produced embryos

Equine Veterinary Journal, EarlyView.
Abstract Background The success of in vitro embryo production (IVEP) is influenced by donor mare and stallion. Objectives To determine whether donor mare and stallion influence the pregnancy rate after transfer of in vitro produced (IVP) blastocysts and to identify factors influencing the likelihood of obtaining one or more pregnancies from a single ...
M. Papas, T. A. E. Stout, J. C. M. Vernooij, B. Leemans, L. Arnold, M. M. Beitsma, L. I. Wijnands, M. de Ruijter‐Villani, S. Colleoni, G. Lazzari, C. Galli, A. Claes   +11 more
wiley   +1 more source

Cell Culture Models of Human Trophoblast II: Trophoblast Cell Lines—A Workshop Report

Placenta, 2001
K. T. Shiverick, A. King, H.-G. Frank, G. St. J. Whitley, J. E. Cartwright and H. Schneider a Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, USA b Department of Pathology, University of Cambridge, Cambridge, UK c Department of Anatomy, University of Technology, Aachen, Germany d Department of Biochemistry and ...
Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, USA ( host institution ), Shiverick, K.T., King, A., Frank, H.-G., Whitley, G.St.J., Cartwright, J.E., Schneider, H.   +6 more
openaire   +3 more sources

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany

International Journal of Cancer, EarlyView.
Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel, Theresa Lowinus, Patrick Metzger, Rebecca Czurda, Vincent Schipperges, Ulrike Paul, Alessandra Rünger, Julian Kött, Isabel Heidrich, Saskia Lehr, Julia Kühn, Heiko Becker, Cornelius Miething, Martin Werner, Silke Laßmann, Justus Duyster, Tilman Brummer, Ronald Simon, Winfried Alsdorf, Maximilian Christopeit, Carsten Bokemeyer, Kilian Eyerich, Stefan W. Schneider, David Rafei, Melanie Börries, Frank Meiss, Christoffer Gebhardt   +26 more
wiley   +1 more source

Effects of Circulating and Local Uteroplacental Angiotensin II in Rat Pregnancy.

, 2010
The renin-angiotensin (Ang) system is important during placental development. Dysregulation of the renin-Ang system is important in preeclampsia (PE). Female rats transgenic for the human angiotensinogen gene crossed with males transgenic for the human ...
Muller, DN, Cartwright, JE, Pijnenborg, R, Pijnenborg, R., Stefan Verlohren, Staff, A.C., Luft, F.C., Mueller, D.N., Lydia Hering, Brosnihan, KB, Anne C. Staff, Berthold Huppertz, Katrin Wenzel, Wenzel, K., Brosnihan, K.B., Dechend, R, Geusens, N, Robert Pijnenborg, Herse, F, Judith E. Cartwright, Herse, F., Wenzel, K, Huppertz, B, Florian Herse, Staff, AC, Ralf Dechend, Nele Geusens, Cartwright, J.E., K. Bridget Brosnihan, Huppertz, B., Geusens, N., Hering, L, Dominik N. Muller, Dechend, R., Hering, L., Verlohren, S, Friedrich C. Luft, Verlohren, S., Luft, FC   +38 more
core   +1 more source

NATURAL KILLER CELL EFFECTS UPON ANGIOGENESIS UNDER CONDITIONS OF CONTACT-DEPENDENT AND DISTANT CO-CULTURING WITH ENDOTHELIAL AND TROPHOBLAST CELLS

Медицинская иммунология, 2019
Regulation of angiogenesis in the utero-placental bed determines adequate trophoblast invasion, placenta formation and development, as well as successful course of pregnancy.
Kseniya Markova, Olga Stepanova, Anastasia Sheveleva, Nikolay Kostin, Valentina Mikhailova, Sergey Selkov, Dmitry Sokolov   +6 more
doaj   +3 more sources

Transient inhibition of MEK/ERK and WNT pathways enhances direct differentiation of primed hPSCs into functional trophoblast stem cells

Cell Regeneration
The placenta plays a pivotal role in human pregnancy, yet research into placental development has been hindered by limited access to early-stage embryos and ethical constraints.
Qifan Jiang, Ping Liu, Chunlin Chen
doaj   +1 more source