Results 101 to 110 of about 51,707 (295)
LifeIn preeclampsia (PE), impaired trophoblast proliferation and differentiation are thought to cause abnormal placentation and subsequent clinical manifestations of the disease, i.e., hypertension, proteinuria, and end-organ damage.
Rebecca Ssengonzi +8 more
doaj +1 more source
Effects of maternal diabetes on trophoblast cells
World Journal of Diabetes, 2015 Diabetes mellitus (DM) is a health condition characterized by hyperglycemia over a prolonged period. There are three main types of DM: DM type 1 (DM1), DM2 and gestational DM (GDM). Maternal diabetes, which includes the occurrence of DM1 and DM2 during pregnancy or GDM, increases the occurrence of gesttional complications and adverse fetal outcomes ...
Marlúcia Bastos, Aires +1 more
openaire +2 more sources
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Since 2019, coronavirus disease 2019 (COVID‐19) has been associated with increased risks of preterm birth and placental complications. We prospectively investigated alterations in microRNAs (miRNAs) and cytokines in placental and amniotic tissues from pregnant women with and without COVID‐19 to evaluate the infection's impact on pregnancy ...
Wei‐Chun Chen +3 more
wiley +1 more source
, 2012 Normal placental development and function is essential for fetal growth of eutherian mammals. Mutational studies have shown that numerous growth factors'are required for placental development and differentiation of placental lineages.
Chiu, H. S. +8 more
core +1 more source
In Vitro Studies of Cultured Rat Trophoblast Cells [PDF]
, 1990 This study was designed to explore the feasibility of using rat trophoblast cells as an animal model for studies of placental growth and regulation. The structural and functional similarities between the giant cells of the rat placenta, and the syncytio ...
Elam, Helen Maeve
core +1 more source
Reproductive Biology and Endocrinology, 2020 Background Trophoblast cells are required for the establishment of pregnancy and fetal development. Apoptosis is an essential feature for trophoblast invasion. Uncontrolled trophoblast apoptosis is related to some complicate pregnancies. Oxidative stress
Bin He +6 more
doaj +1 more source
Expression and Localization of StarD7 in Trophoblast Cells
Placenta, 2008 The StAR-related lipid transfer (START) domain is defined as a motif of around 200 amino acids implicated in lipid/sterol binding. In a previous study, we identified the StarD7 transcript encoding one of the 15 family members with START domain present in the human genome. This transcript was found to be overexpressed in choriocarcinoma JEG-3 cells.
Angeletti, Sofia Claudia +5 more
openaire +3 more sources
Hemophilia A: An Ideal Disease for Prenatal Therapy
Prenatal Diagnosis, EarlyView.ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada +2 more
wiley +1 more source
Prenatal Diagnosis, EarlyView.ABSTRACT Objective While RNAseq has enhanced variant interpretation in postnatal cases, its potential in the prenatal setting remains underexplored. This study investigates the utility of RNAseq in prenatal diagnostics by analyzing the expression profiles of cultured chorionic villus samples (cCVS) and amniotic fluid (cAF) samples. Methods We performed
Maria C. Vladoiu +7 more
wiley +1 more source
Entosis Allows Timely Elimination of the Luminal Epithelial Barrier for Embryo Implantation
Cell Reports, 2015 During implantation, uterine luminal epithelial (LE) cells first interact with the blastocyst trophectoderm. Within 30 hr after the initiation of attachment, LE cells surrounding the blastocyst in the implantation chamber (crypt) disappear, allowing ...
Yingju Li, Xiaofei Sun, Sudhansu K. Dey
doaj +1 more source