Results 1 to 10 of about 27,963 (143)

Proinflammatory response of canine trophoblasts to Brucella canis infection. [PDF]

PLoS ONE, 2017
Brucella canis infection is an important cause of late-term abortion in pregnant bitches. The pathophysiological mechanisms leading to B. canis-induced abortion are unknown, but heavily infected trophoblasts are consistently observed.
Andrea G Fernández, M Soledad Hielpos, Mariana C Ferrero, Carlos A Fossati, Pablo C Baldi   +4 more
doaj   +4 more sources

Regulation of trophoblast beta1-integrin expression by contact with endothelial cells [PDF]

Cell Communication and Signaling, 2004
Background In human and non-human primates, migratory trophoblasts penetrate the uterine epithelium, invade uterine matrix, and enter the uterine vasculature. Invasive trophoblasts show increased expression of β1 integrin.
Thirkill Twanda L, Hendren Sonia R, Soghomonians Arlen, Mariano Natalie F, Barakat Abdul I, Douglas Gordon C   +5 more
doaj   +4 more sources

The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ [PDF]

Advanced Science
Abnormal adipogenesis is a major contributor to fetal growth restriction (FGR) and its associated complications. However, the underlying etiology remains unclear.
Xiaofang Luo, Biao Huang, Ping Xu, Hao Wang, Baozhen Zhang, Li Lin, Jiujiang Liao, Mingyu Hu, Xiyao Liu, Jiayu Huang, Yong Fu, Mark D. Kilby, Rodney E. Kellems, Xiujun Fan, Yang Xia, Philip N. Baker, Hongbo Qi, Chao Tong   +17 more
doaj   +2 more sources

Follistatin Is a Novel Chemoattractant for Migration and Invasion of Placental Trophoblasts of Mice

Cells, 2022
Follistatin (FST) as a gonadal protein is central to the establishment and maintenance of pregnancy. Trophoblasts’ migration and invasion into the endometrium are critical events in placental development.
Jing Li, Yan Qi, Ke Yang, Linjing Zhu, Xueling Cui, Zhonghui Liu   +5 more
doaj   +1 more source

Chorionic villus-derived mesenchymal stem cell-mediated autophagy promotes the proliferation and invasiveness of trophoblasts under hypoxia by activating the JAK2/STAT3 signalling pathway

Cell & Bioscience, 2021
Background Trophoblast dysfunction during pregnancy is fundamentally involved in preeclampsia. Several studies have revealed that human chorionic villous mesenchymal stem cells (CV-MSCs) could regulate trophoblasts function.
Yijing Chu, Chengzhan Zhu, Chongyu Yue, Wei Peng, Weiping Chen, Guifang He, Changchang Liu, Yang Lv, Guoqiang Gao, Ke Yao, Rendong Han, Xiaoyu Hu, Yan Zhang, Yuanhua Ye   +13 more
doaj   +1 more source

The Expression and Localization of N-Myc Downstream-Regulated Gene 1 in Human Trophoblasts [PDF]

, 2013
The protein N-Myc downstream-regulated gene 1 (NDRG1) is implicated in the regulation of cell proliferation, differentiation, and cellular stress response.
A Fotovati, A Karaczyn, B Chen, B Xu, Baosheng Chen, CR Roh, D Pflueger, D Piquemal, DM Byers, DM Nelson, E Alsat, E Shaw, EA Mostaghel, Eric Y. Chuang, EU Jung, HJ Kliman, J Hwang, Jacob C. Larkin, JF Mouillet, JR Hickok, K Hirata, K Kokame, K Ogata, KJ Livak, KT Kim, L Aravind, L Kalaydjieva, LW Donaldson, M Hunter, M Hunter, MA Zoroddu, N van Belzen, NT Le, O Genbacev, P Lachat, RB Donker, RH King, RK Riemer, RP Caruso, S Bandyopadhyay, S Chen, S Sibold, S Smith, S Stein, SJ Choi, SK Kachhap, SK Kurdistani, T Fujii, T Matsugaki, T Mishima, T Okuda, T Sugiki, TM Lin, V Melotte, VM Banz, W Ulrix, WT Schaiff, X Qu, X Xu, Xiao-Hua Shi, Y Sadovsky, Y Sadovsky, Y Song, Y Taketomi, Y Zhou, Yoel Sadovsky, Z Chen, Z Kovacevic   +67 more
core   +11 more sources

ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis

Frontiers in Cell and Developmental Biology, 2021
Coordination of cell-cell adhesion, actomyosin dynamics and gene expression is crucial for morphogenetic processes underlying tissue and organ development. Rho GTPases are main regulators of the cytoskeleton and adhesion.
Robert Beal, Ana Alonso-Carriazo Fernandez, Dimitris K. Grammatopoulos, Dimitris K. Grammatopoulos, Karl Matter, Maria S. Balda   +5 more
doaj   +1 more source

Crosstalk Between Trophoblasts and Decidual Immune Cells: The Cornerstone of Maternal-Fetal Immunotolerance

Frontiers in Immunology, 2021
The success of pregnancy relies on the fine adjustment of the maternal immune system to tolerate the allogeneic fetus. Trophoblasts carrying paternal antigens are the only fetal-derived cells that come into direct contact with the maternal immune cells ...
Ling Xu, Yanhong Li, Yifei Sang, Da-Jin Li, Meirong Du, Meirong Du   +5 more
doaj   +1 more source

A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells

Frontiers in Toxicology, 2022
Per- and polyfluoroalkyl substances (PFAS) have become ubiquitous environmental contaminants that have been associated with adverse pregnancy outcomes in women and experimental research models.
Bevin E. Blake, Bevin E. Blake, Brittany P. Rickard, Suzanne E. Fenton   +3 more
doaj   +1 more source

Vertical Zika Virus Transmission at the Maternal-Fetal Interface

Frontiers in Virology, 2022
Zika virus (ZIKV) is spread by mosquito bites or via sexual or vertical transmission. ZIKV-infected adults are generally asymptomatic, but can display mild symptoms including fever, joint pain, rash and conjunctivitis. However, during pregnancy, vertical
Ozlem Guzeloglu-Kayisli, Umit Ali Kayisli, Frederick Schatz, Charles Joseph Lockwood   +3 more
doaj   +1 more source