Results 11 to 20 of about 40,342 (338)

Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia

Lipids in Health and Disease, 2023
Background The adipokine chemerin regulates adipogenesis and the metabolic function of both adipocytes and liver. Chemerin is elevated in preeclamptic women, and overexpression of chemerin in placental trophoblasts induces preeclampsia-like symptoms in ...
Lunbo Tan, Zijun Ouyang, Zhilong Chen, Fen Sun, Haichun Guo, Feng Wang, Monique Mulder, Yuan Sun, Xifeng Lu, Jian V. Zhang, A. H. Jan Danser, Koen Verdonk, Xiujun Fan, Qing Yang   +13 more
doaj   +1 more source

Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia

Frontiers in Cell and Developmental Biology, 2022
It is now well-established that microRNAs (miRNAs) are important regulators of gene expression. The role of miRNAs in placental development and trophoblast function is constantly expanding. Trophoblast invasion and their ability to remodel uterine spiral
Heyam Hayder, Yanan Shan, Yan Chen, Jacob Anderson O’Brien, Chun Peng, Chun Peng   +5 more
doaj   +1 more source

Obesity and Maternal-Placental-Fetal Immunology and Health

Frontiers in Pediatrics, 2022
Obesity rates in women of childbearing age is now at 29%, according to recent CDC reports. It is known that obesity is associated with oxidative stress and inflammation, including disruptions in cellular function and cytokine levels.
Meredith Monaco-Brown, David A. Lawrence, David A. Lawrence   +2 more
doaj   +1 more source

Trophoblast development [PDF]

REPRODUCTION, 2012
This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies,in vivoloss-of-function models andin vitrosystems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain trophoblast ontogeny via gene ...
Peter L, Pfeffer, David J, Pearton
openaire   +2 more sources

TGF-β1 Promotes Zika Virus Infection in Immortalized Human First-Trimester Trophoblasts via the Smad Pathway

Cells, 2022
The Zika virus (ZIKV) is well known for causing congenital Zika syndrome if the infection occurs during pregnancy; however, the mechanism by which the virus infects and crosses the placenta barrier has not been completely understood. In pregnancy, TGF-β1
Quang Duy Trinh, Ngan Thi Kim Pham, Kazuhide Takada, Chika Takano, Shihoko Komine-Aizawa, Satoshi Hayakawa   +5 more
doaj   +1 more source

Enhancement of Rubella Virus Infection in Immortalized Human First-Trimester Trophoblasts Under Low-Glucose Stress Conditions

Frontiers in Microbiology, 2022
Rubella virus (RuV) infections in pregnant women, especially first-trimester infections, can lead to congenital rubella syndrome (CRS). However, the mechanisms of fetal RuV infection are not completely understood, and it is not observed in every pregnant
Quang Duy Trinh, Kazuhide Takada, Ngan Thi Kim Pham, Chika Takano, Takahiro Namiki, Ryo Ikuta, Shingo Hayashida, Shoko Okitsu, Hiroshi Ushijima, Shihoko Komine-Aizawa, Satoshi Hayakawa   +10 more
doaj   +1 more source

Engineering placenta‐like organoids containing endogenous vascular cells from human‐induced pluripotent stem cells

Bioengineering & Translational Medicine, 2023
The placenta is an essential organ that maintains the health of both the fetus and its mother. Understanding the development of human placenta has been hindered by the limitations of existing animal models and monolayer cell cultures.
Kangli Cui, Tingwei Chen, Yujuan Zhu, Yang Shi, Yaqiong Guo, Jianhua Qin   +5 more
doaj   +1 more source

Formation of atypical podosomes in extravillous trophoblasts regulates extracellular matrix degradation [PDF]

, 2012
Throughout pregnancy the cytotrophoblast, the stem cell of the placenta, gives rise to the differentiated forms of trophoblasts. The two main cell lineages are the syncytiotrophoblast and the invading extravillous trophoblast.
Alexander, Anand Patel, Artym, Ayling, Baldassarre, Barker, Behrendtsen, Bowden, Buccione, Buccione, Burgstaller, Calle, Cartwright, Cartwright, Cartwright, Chan, Destaing, Destaing, Goldman-Wohl, Harris, Harris, Isaka, Kam, Kaufmann, Kelley, LaMarca, Linder, Linder, Linder, Mueller, Nakahara, Philip R. Dash, Redondo-Munoz, Sabri, Sato, Weaver, Whitley, Xiao   +37 more
core   +2 more sources

Trophoblasts, invasion, and microRNA [PDF]

Frontiers in Genetics, 2013
MicroRNAs (miRNAs) have recently become essential actors in various fields of physiology and medicine, especially as easily accessible circulating biomarkers, or as modulators of cell differentiation. To this respect, terminal differentiation of trophoblasts (the characteristic cells of the placenta in Therian mammals) into syncytiotrophoblast, villous
Doridot, Ludivine, Miralles, Francisco, Barbaux, Sandrine, Vaiman, Daniel   +3 more
openaire   +6 more sources

Downregulation of Transcriptional Activity, Increased Inflammation, and Damage in the Placenta Following in utero Zika Virus Infection Is Associated With Adverse Pregnancy Outcomes

Frontiers in Virology, 2022
Zika virus (ZIKV) infection during pregnancy causes serious adverse outcomes to the developing fetus, including fetal loss and birth defects known as congenital Zika syndrome (CZS). The mechanism by which ZIKV infection causes these adverse outcomes, and
Patrick S. Creisher, Jun Lei, Morgan L. Sherer, Amanda Dziedzic, Anne E. Jedlicka, Harish Narasimhan, Anna Chudnovets, Ariana D. Campbell, Anguo Liu, Andrew Pekosz, Irina Burd, Sabra L. Klein   +11 more
doaj   +1 more source