Results 21 to 30 of about 43,593 (324)

Factors associated with gestational trophoblastic disease at the Hipólito Unánue Hospital during the period from January 2014 to December 2018

Revista de la Facultad de Medicina Humana, 2020
Objective: To determine the risk factors associated with gestational trophoblastic disease in patients treated in an outpatient office of the Gynecobstetrics service of the National Hospital Hipólito Unanue between January 2014 and December 2018. Methods:
Johana Huanca-Llamo, German Aranzabal-Alegria, Willer Chanduví   +2 more
doaj   +1 more source

Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia

Frontiers in Cell and Developmental Biology, 2022
It is now well-established that microRNAs (miRNAs) are important regulators of gene expression. The role of miRNAs in placental development and trophoblast function is constantly expanding. Trophoblast invasion and their ability to remodel uterine spiral
Heyam Hayder, Yanan Shan, Yan Chen, Jacob Anderson O’Brien, Chun Peng, Chun Peng   +5 more
doaj   +1 more source

Amnion-Derived Mesenchymal Stem Cell Exosomes-Mediated Autophagy Promotes the Survival of Trophoblasts Under Hypoxia Through mTOR Pathway by the Downregulation of EZH2

Frontiers in Cell and Developmental Biology, 2020
Human amnion-derived mesenchymal stem cells (AD-MSCs) have been reported as a promising effective treatment to repair tissue. Trophoblast dysfunction during pregnancy is significantly involved in the pathogenesis of preeclampsia (PE).
Yijing Chu, Weiping Chen, Wei Peng, Yong Liu, Lin Xu, Jianxin Zuo, Jun Zhou, Yan Zhang, Ning Zhang, Jing Li, Ling Liu, Ke Yao, Guoqiang Gao, Xiaofei Wang, Rendong Han, Chong Liu, Yan Li, Huansheng Zhou, Yuxiang Huang, Yuanhua Ye   +19 more
doaj   +1 more source

A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells

Frontiers in Toxicology, 2022
Per- and polyfluoroalkyl substances (PFAS) have become ubiquitous environmental contaminants that have been associated with adverse pregnancy outcomes in women and experimental research models.
Bevin E. Blake, Bevin E. Blake, Brittany P. Rickard, Suzanne E. Fenton   +3 more
doaj   +1 more source

Vertical Zika Virus Transmission at the Maternal-Fetal Interface

Frontiers in Virology, 2022
Zika virus (ZIKV) is spread by mosquito bites or via sexual or vertical transmission. ZIKV-infected adults are generally asymptomatic, but can display mild symptoms including fever, joint pain, rash and conjunctivitis. However, during pregnancy, vertical
Ozlem Guzeloglu-Kayisli, Umit Ali Kayisli, Frederick Schatz, Charles Joseph Lockwood   +3 more
doaj   +1 more source

ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis

Frontiers in Cell and Developmental Biology, 2021
Coordination of cell-cell adhesion, actomyosin dynamics and gene expression is crucial for morphogenetic processes underlying tissue and organ development. Rho GTPases are main regulators of the cytoskeleton and adhesion.
Robert Beal, Ana Alonso-Carriazo Fernandez, Dimitris K. Grammatopoulos, Dimitris K. Grammatopoulos, Karl Matter, Maria S. Balda   +5 more
doaj   +1 more source

Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions. [PDF]

, 2005
Objective— Invasion of uterine spiral arteries by extravillous trophoblasts in the first trimester of pregnancy results in loss of endothelial and musculoelastic layers.
Ashton, SV, Baker, PN, Cartwright, JE, Crocker, IP, Dash, PR, Wareing, M, Whitley, GS   +6 more
core   +1 more source

Chorion laeve trophoblasts of preeclamptic fetal membranes: histochemically detectable enzyme activities do not change at a subcellular level

European Journal of Histochemistry, 2009
We examined the subcellular localization of ADPdegrading activity and cytochrome c oxidase (CCO) activity in chorion laeve trophoblasts from term and near term human fetal membranes, and compared them with those from severe preeclamptic fetal membranes ...
S Matsubara, T Takayama, R Iwasaki, A Izumi, T Watanabe, I Sato   +5 more
doaj   +1 more source

TGF-β1 Promotes Zika Virus Infection in Immortalized Human First-Trimester Trophoblasts via the Smad Pathway

Cells, 2022
The Zika virus (ZIKV) is well known for causing congenital Zika syndrome if the infection occurs during pregnancy; however, the mechanism by which the virus infects and crosses the placenta barrier has not been completely understood. In pregnancy, TGF-β1
Quang Duy Trinh, Ngan Thi Kim Pham, Kazuhide Takada, Chika Takano, Shihoko Komine-Aizawa, Satoshi Hayakawa   +5 more
doaj   +1 more source

Interferon gamma is involved in apoptosis of trophoblast cells at the maternal–fetal interface following Toxoplasma gondii infection

International Journal of Infectious Diseases, 2015
Objective: To assess whether interferon gamma (IFN-γ) secreted by decidual natural killer (dNK) cells at the maternal–fetal interface is involved in the apoptosis of trophoblast cells (trophoblasts) following Toxoplasma gondii infection.
Ling Zhang, Mingdong Zhao, Fang Jiao, Xiaoyan Xu, Xianbing Liu, Yuzhu Jiang, Haixia Zhang, Xiaoxuan Ou, Xuemei Hu   +8 more
doaj   +1 more source