Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and Neurodevelopmental Abnormalities. [PDF]
, 2018 During its most recent outbreak across the Americas, Zika virus (ZIKV) was surprisingly shown to cause fetal loss and congenital malformations in acutely and chronically infected pregnant women.
Aagaard, Kjersti M +17 more
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Modeling human trophoblast, the placental epithelium at the maternal fetal interface. [PDF]
, 2020 Appropriate human trophoblast lineage specification and differentiation is crucial for the establishment of normal placentation and maintenance of pregnancy. However, due to the lack of proper modeling systems, the molecular mechanisms of these processes
Bui, Tony +3 more
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Clinical Pharmacology &Therapeutics, EarlyView.In pediatric oncology, pharmacogenetic guidelines are underutilized and the potential impact of pre‐emptive pharmacogenetic screening remains largely unexplored despite this field's need for individualized approaches. While comprehensive pharmacogenetic guidelines are not yet available for all anticancer drugs, evidence‐based recommendations exist for ...
Emma C. Bernsen +12 more
wiley +1 more source
Viruses, 2018 Rubella virus (RuV), which belongs to the family Togaviridae and genus Rubivirus, causes systemic infection in children and young adults and congenital rubella syndrome in developing fetuses if the infection occurs during pregnancy.
Quang Duy Trinh +4 more
doaj +1 more source
Effects of estradiol on HIF-1α expression and trophoblast differentiation in first trimester villous explant cultures [PDF]
Obstetrics & Gynecology Science, 2018 ObjectiveThe purpose of this study was to investigate the effects of estradiol on the expression of hypoxia-inducible factor (HIF)-1α and the differentiation of trophoblasts in human first trimester villous explant cultures.MethodsVillous explant ...
Geum Joon Cho +7 more
doaj +1 more source
Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function. [PDF]
, 2014 STUDY QUESTION Are the concentrations of factors secreted by decidual natural killer (dNK) cells from pregnancies at high risk of poor spiral artery remodelling different to those secreted from pregnancies at low risk?
A. E. Wallace +35 more
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A head start: The relationship of placental factors to craniofacial and brain development
Developmental Dynamics, EarlyView.Abstract In recent years, the importance of placental function for fetal neurodevelopment has become increasingly studied. This field, known as neuroplacentology, has greatly expanded possible etiologies of neurodevelopmental disorders by exploring the influence of placental function on brain development.
Annemarie Jenna Carver +2 more
wiley +1 more source
Obstetric anti-phospholipid syndrome: from pathogenesis to treatment
Immunological Medicine, 2021 Antiphospholipid syndrome (APS) is an autoimmune disease characterized by clinical manifestations such as thrombosis and obstetric complications with documented persistence of antiphospholipid antibodies (aPLs).
Kayoko Kaneko +2 more
doaj +1 more source
Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development. [PDF]
, 2002 The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombomodulin.thrombin complex. Deletion of the EPCR gene in mice has been reported to lead to embryonic lethality before embryonic day 10 (E10.0). To identify potential
Crawley, JT +3 more
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Immunobiology of Acute Chorioamnionitis. [PDF]
, 2020 Acute chorioamnionitis is characterized by neutrophilic infiltration and inflammation at the maternal fetal interface. It is a relatively common complication of pregnancy and can have devastating consequences including preterm labor, maternal infections,
Cappelletti, Monica +2 more
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