Results 11 to 20 of about 6,608 (237)

Tropoelastin and Elastin Assembly [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
Elastic fibers are an important component of the extracellular matrix, providing stretch, resilience, and cell interactivity to a broad range of elastic tissues.
Jazmin Ozsvar, Jazmin Ozsvar, Chengeng Yang, Stuart A. Cain, Clair Baldock, Anna Tarakanova, Anna Tarakanova, Anthony S. Weiss, Anthony S. Weiss, Anthony S. Weiss   +9 more
doaj   +5 more sources

Fibulin-4 and -5, but not Fibulin-2, are Associated with Tropoelastin Deposition in Elastin-Producing Cell Culture [PDF]

, 2010
Elastic system fibers consist of microfibrils and tropoelastin. During development, microfibrils act as a template on which tropoelastin is deposited. Fibrillin-1 is the major component of microfibrils.
Ishikawa, Hiroyuki, Nakashima, Kazuki, Sawa, Yoshihiko, Tsuruga, Eichi, Yamauchi, Yoshinori   +4 more
core   +4 more sources

Radioimmunological identification of tropoelastin [PDF]

Biochemical Journal, 1976
Antiserum was prepared in sheep against insoluble elastin isolated from embryonic-chick aortae. In an indirect immunoprecipitation test, the antiserum reacted quantitatively with small amounts of radioactively labelled purified tropoelastin prepared from embryonic-chick aortae. The antiserum did not cross-react with chick procollagen, and the antiserum
Paul J. Christner, Malia M. Dixon, A Cywinski, J. Rosenbloom   +3 more
openalex   +4 more sources

Assessing the feasibility of CRISPRa approaches to enhance protein-based biomaterial expression in bacterial systems for more efficient production [PDF]

Materials Today Bio
Recombinant protein production is crucial for biomedical and industrial applications; however, achieving high yields for complex protein-like biomaterials such as elastin-like recombinamers (ELRs) remains challenging. ELRs, protein-based polymers derived
Pablo Rodríguez-Alonso, Viktoriya Chaskovska, Desiré Venegas-Bustos, Alba Herraiz, Matilde Alonso, Jose Carlos Rodríguez-Cabello   +5 more
doaj   +2 more sources

Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA

Molecular Therapy: Nucleic Acids, 2023
Loss of elastin due to aging, disease, or injury can lead to impaired tissue function. In this study, de novo tropoelastin (TE) synthesis is investigated in vitro and in vivo using different TE-encoding synthetic mRNA variants after codon optimization ...
Sonia Golombek, Thomas Hoffmann, Ludmilla Hann, Markus Mandler, Sabine Schmidhuber, Josefin Weber, Young-Tae Chang, Roman Mehling, Andrea Ladinig, Christian Knecht, Johanna Leyens, Christian Schlensak, Hans Peter Wendel, Achim Schneeberger, Meltem Avci-Adali   +14 more
doaj   +5 more sources

Application of Antioxidant Mixture Prevents Cutaneous "Oxinflammaging" in Subjects Exposed to Particulate Matter. [PDF]

J Cosmet Dermatol
ABSTRACT Background Premature skin aging and the growing incidence of skin conditions are closely linked to daily exposure to environmental agents. Among all air pollutants, particulate matter (PM) is regarded as one of the most aggressive in terms of skin damage, promoting degradation of extracellular matrix (ECM) components and depletion of the ...
Ivarsson J, Yan X, Guiotto A, Pecorelli A, Sarandy MM, Lynch S, Anderias S, Choudhary H, White S, Ferrara F, Valacchi G.   +10 more
europepmc   +2 more sources

Fibulin-4 and latent-transforming growth factor beta-binding protein-4 interactions with syndecan-2 and syndecan-3 are required for elastogenesis. [PDF]

FASEB J
Molecular mechanisms in cell‐associated elastic fiber assembly. Abstract Elastogenesis is a cell surface‐located hierarchical process that requires the core components tropoelastin and fibrillins and several accessory proteins, including fibulin‐4 (FBLN4) and latent TGF‐β binding protein‐4 (LTBP4).
Hakami H, Dinesh NEH, Nelea V, Lamarche-Vane N, Ricard-Blum S, Reinhardt DP.   +5 more
europepmc   +2 more sources

Tropoelastin [PDF]

Circulation: Cardiovascular Imaging, 2018
Background: Elastolysis and ineffective elastogenesis favor the accumulation of tropoelastin, rather than cross-linked elastin, in atherosclerotic plaques. We developed gadolinium-labeled tropoelastin-specific magnetic resonance contrast agents for tropoelastin imaging in animal models. Methods
Alkystis Phinikaridou, Sara Lacerda, Begoña Lavin, Marcelo E. Andía, Alberto Smith, Prakash Saha, René M. Botnar   +6 more
  +8 more sources

Comparing UV and Diesel Cutaneous Damage and Evaluating the Protective Role of a Topical Antioxidant Mixture Containing Vitamin C, E and Ferulic Acid. [PDF]

Exp Dermatol
Effect of PM versus UV on skin oxinflammatory and structural responses. Thicker arrows indicate a stronger effect. Red colours are noxious effects while green colours indicate a protective responses by topical antioxidants (AOX) application. ABSTRACT Cutaneous tissue is one of the main targets of outdoor stressors, and nowadays, the effect of pollution
Ivarsson J, Pecorelli A, Guiotto A, Souza MM, Choudhary H, Brieva P, Ferrara F, Valacchi G.   +7 more
europepmc   +2 more sources

The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging (Adv. Sci. 39/2024) [PDF]

Advanced science
Sunny Shinchen Lee, Aleen Al Halawani, Jonathan D. Teo, Anthony S. Weiss, Giselle C. Yeo   +4 more
europepmc   +2 more sources