Results 11 to 20 of about 7,724 (232)

Tropoelastin Improves Post-Infarct Cardiac Function. [PDF]

Circ Res, 2023
Background: Myocardial infarction (MI) is among the leading causes of death worldwide. Following MI, necrotic cardiomyocytes are replaced by a stiff collagen-rich scar. Compared to collagen, the extracellular matrix protein elastin has high elasticity and may have more favorable properties within the cardiac scar.
Hume RD, Kanagalingam S, Deshmukh T, Chen S, Mithieux SM, Rashid FN, Roohani I, Lu J, Doan T, Graham D, Clayton ZE, Slaughter E, Kizana E, Stempien-Otero AS, Brown P, Thomas L, Weiss AS, Chong JJH.   +17 more
europepmc   +5 more sources

Tropoelastin [PDF]

Circulation: Cardiovascular Imaging, 2018
Background: Elastolysis and ineffective elastogenesis favor the accumulation of tropoelastin, rather than cross-linked elastin, in atherosclerotic plaques. We developed gadolinium-labeled tropoelastin-specific magnetic resonance contrast agents for tropoelastin imaging in animal models. Methods
Alkystis Phinikaridou, Sara Lacerda, Begoña Lavín, Marcelo E. Andía, Alberto Smith, Prakash Saha, René M. Botnar   +6 more
  +11 more sources

In Vitro and In Silico Studies on Angiotensin I-Converting Enzyme Inhibitory Peptides Found in Hydrophobic Domains of Porcine Elastin [PDF]

Molecules, 2023
One of the most striking aspects of the primary structure in the hydrophobic domains of the tropoelastin molecule is the occurrence of the VAPGVG repeating sequence.
Toshiya Hatakenaka, Tamaki Kato, Kouji Okamoto   +2 more
doaj   +2 more sources

Imaging Tropoelastin in Atherosclerosis [PDF]

Circulation: Cardiovascular Imaging, 2018
Raphaël Duivenvoorden, Willem J. M. Mulder   +1 more
openalex   +5 more sources

Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells [PDF]

Nature Communications
Microfibril-associated glycoprotein 4 (MFAP4) is a 36-kDa extracellular matrix glycoprotein with critical roles in organ fibrosis, chronic obstructive pulmonary disease, and cardiovascular disorders, including aortic aneurysms.
Michael R. Wozny, Valentin Nelea, Iram Fatima S. Siddiqui, Shaynah Wanga, Vivian de Waard, Mike Strauss, Dieter P. Reinhardt   +6 more
doaj   +2 more sources

RiboScreen^TM Technology Delivers a Ribosomal Target and a Small-Molecule Ligand for Ribosome Editing to Boost the Production Levels of Tropoelastin, the Monomeric Unit of Elastin. [PDF]

Int J Mol Sci
Wimmer B, Schernthaner J, Edobor G, Friedrich A, Poeltner K, Temaj G, Wimmer M, Kronsteiner E, Pichler M, Gercke H, Huber R, Kaefer N, Rinnerthaler M, Karl T, Krauß J, Mohr T, Gerner C, Hintner H, Breitenbach M, Bauer JW, Rakers C, Kuhn D, von Hagen J, Müller N, Rathner A, Breitenbach-Koller H.   +25 more
europepmc   +3 more sources

The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging (Adv. Sci. 39/2024) [PDF]

Advanced science
Sunny Shinchen Lee, Aleen Al Halawani, Jonathan D. Teo, Anthony S. Weiss, Giselle C. Yeo   +4 more
europepmc   +3 more sources

Assessing the feasibility of CRISPRa approaches to enhance protein-based biomaterial expression in bacterial systems for more efficient production [PDF]

Materials Today Bio
Recombinant protein production is crucial for biomedical and industrial applications; however, achieving high yields for complex protein-like biomaterials such as elastin-like recombinamers (ELRs) remains challenging. ELRs, protein-based polymers derived
Pablo Rodríguez-Alonso, Viktoriya Chaskovska, Desiré Venegas-Bustos, Alba Herraiz, Matilde Alonso, Jose Carlos Rodríguez-Cabello   +5 more
doaj   +2 more sources

Impact of N-linked glycans on the dual short fibulin/LTBP-4 axes regulating elastogenesis. [PDF]

FEBS J
Elastic fiber assembly is orchestrated by multiple glycoproteins. We delineate the molecular basis of two key axes involved in elastic fiber formation—LTBP‐4L/fibulin‐4 and LTBP‐4S/fibulin‐5. We show that N‐linked glycans on these glycoproteins regulate their interactions and conformations, both of which are critical aspects in elastic fiber formation.
Nelea V, Kumra H, Lee CS, Williamson D, Hakami H, Zhang RM, Dinesh NEH, Haltiwanger R, Reinhardt DP.   +8 more
europepmc   +2 more sources

Fabrication of PCL Blended Highly Aligned Nanofiber Yarn from Dual-Nozzle Electrospinning System and Evaluation of the Influence on Introducing Collagen and Tropoelastin. [PDF]

ACS Biomater Sci Eng
Zha D, Mahmood N, Kellar RS, Gluck JM, King MW.   +4 more
europepmc   +2 more sources