Results 111 to 120 of about 4,124 (226)

A phenomenological density-scaling approach to lamellipodial actin dynamics [PDF]

, 2014
The integration of protein function studied in vitro in a dynamic system like the cell lamellipodium remains a significant challenge. One reason is the apparent contradictory effects that perturbations of some proteins can have on the overall ...
Charras, G, Duke, T, Fritzsche, M, Lewalle, A, Thorogate, R, Wilson, K   +5 more
core   +1 more source

TMOD2 and DOCK4 as Novel Gut Microbiota‐Associated Biomarkers for Colorectal Adenoma: Integrated Transcriptomic Analysis and Therapeutic Target Identification

Mediators of Inflammation, Volume 2025, Issue 1, 2025.
Colorectal adenomas (CRA) represent critical precursors to colorectal cancer (CRC), yet reliable transcriptomic biomarkers for early detection and therapeutic targeting remain limited. Integration of gut microbiota (GM) genetics with transcriptomics offers a novel approach to identify disease‐associated molecular signatures.
Chuang Liu, Li Wang, Jianguo Huai, Song He, Qiang Su, Qiuming Min, Zhenxiang An, Liu Jinhui   +7 more
wiley   +1 more source

The true story of Yeti, the "abominable" heterochromatic gene of drosophila melanogaster [PDF]

, 2019
The Drosophila Yeti gene (CG40218) was originally identified by recessive lethal mutation and subsequently mapped to the deep pericentromeric heterochromatin of chromosome 2. Functional studies have shown that Yeti encodes a 241 amino acid protein called
Cuticone, Stefano, DELLE MONACHE, Francesca, Dimitri, Patrizio, Ferreri, Diego, Messina, Giovanni, Prozzillo, Yuri   +5 more
core   +1 more source

Optimization of ultracentrifugation‐based method to enhance the purity and proteomic profiling depth of plasma‐derived extracellular vesicles and particles

Journal of Extracellular Biology, Volume 3, Issue 7, July 2024.
Abstract Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasma has posed a challenge of in‐depth analysis of the EVP proteome. Here, we compared the effectiveness of
Zurong Wan, Jinghua Gu, Uthra Balaji, Linda Bojmar, Henrik Molina, Søren Heissel, Alexandra E. Pagano, Christopher Peralta, Lee Shaashua, Dorina Ismailgeci, Hope K. Narozniak, Yi Song, William R. Jarnagin, David P. Kelsen, Jaqueline Bromberg, Virginia Pascual, Haiying Zhang   +16 more
wiley   +1 more source

Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology [PDF]

BioMed Research International, 2011
Efficient striated muscle contraction requires precise assembly and regulation of diverse actin filament systems, most notably the sarcomeric thin filaments of the contractile apparatus. By capping the pointed ends of actin filaments, tropomodulins (Tmods) regulate actin filament assembly, lengths, and stability.
Gokhin, David S., Fowler, Velia M.
openaire   +2 more sources

Broad bean (Vicia faba L.) caused abnormal lipid metabolism in grass carp (Ctenopharyngodon idellus) liver: Insight from the gut microbiota–liver axis

Food Frontiers, Volume 5, Issue 3, Page 1338-1352, May 2024.
The long‐term consumption of broad bean, especially unprocessed ones, can lead to hepatic lipid accumulation. The glycolysis inhibition, increased de novo lipogenesis, abnormalities in lipid metabolism and activation of oxidative stress were the key processes involved in broad bean‐induced hepatic lipid accumulation.
Bing Fu, Huawei Ma, Huici Yang, Mengping Zheng, Junming Zhang, Yichao Li, Yihui Du, Guangjun Wang, Jingjing Tian, Kai Zhang, Yun Xia, Zhifei Li, Wangbao Gong, Hongyan Li, Jun Xie, Huirong Yang, Ermeng Yu   +16 more
wiley   +1 more source

Glucagon-Like Peptide-1 Protects Human Islets against Cytokine-Mediated β-Cell Dysfunction and Death: A Proteomic Study of the Pathways Involved [PDF]

, 2013
Glucagon-like peptide-1 (GLP-1) has been shown to protect pancreatic β-cells against cytokine-induced dysfunction and destruction. The mechanisms through which GLP-1 exerts its effects are complex and still poorly understood. The aim of this study was to
Ahlemann M., Alexandraki K., Baggio L. L., Bugliani M., Bulotta A., Cardozo A. K., Cardozo A. K., Chantal Mathieu, Chiu T. T., Cnop M., Cooper J. A., De Leon D. D., Dieter Rondas, Donath M. Y., Dotta F., Doyle M. E., Drucker D. J., Dunne J. L., D’Hertog W., Eizirik D. L., Etienne Waelkens, Fonseca S. G., Fred R. G., Gurzov E. N., Gysemans C. A., Harding H. P., Holst J. J., Hui H., Johannesen J., Kasper Lage, Kibbey R. G., Kutlu B., Kutlu B., Lage K., Larsen P. M., Lut Overbergh, Mann M., Marchetti P., Marchetti P., Marco Bugliani, Masini M., Mathilde Masini, Meloni A. R., Mueller C. M., Piero Marchetti, Planas R., Poukkula M., Rabinovitch A., Rasschaert J., Rieneck K., Rolin B., Rondas D., Sarkar S. A., Sarkar S. A., Sparre T., Srinivasan M., Suen C. S., Tews D., Thurmond D. C., Tourrel C., Velmurugan K., Wang C., Wannes D’Hertog, Watanabe T., Weber A.   +64 more
core   +2 more sources

Proteomic profiling of circulating β‐thalassaemia/haemoglobin E extra‐cellular vesicles reveals that association with immunoglobulin induces membrane vesiculation

British Journal of Haematology, Volume 204, Issue 5, Page 2025-2039, May 2024.
Medium extra‐cellular vesicles (mEVs) from splenectomised β‐thalassaemia/haemoglobin E (HbE) patients play important roles in thromboembolic complications. A proteomic analysis identified 72 proteins unique to splenectomised mEVs, including immunoglobulin subunits and cytoskeleton proteins.
Kunwadee Phongpao, Nuttanan Pholngam, Daranee Chokchaichamnankit, Khanita Nuamsee, Rattanaporn Praneetponkang, Puey Ounjai, Kittiphong Paiboonsukwong, Panjaree Siwaponanan, Kovit Pattanapanyasat, Jisnuson Svasti, Chantragan Srisomsap, Churat Weeraphan, Pornthip Chaichompoo, Saovaros Svasti   +13 more
wiley   +1 more source

Supplementary Figure S1 from Tropomodulin 1 Expression Driven by NF-κB Enhances Breast Cancer Growth

, 2023
Taku Ito-Kureha, Naohiko Koshikawa, Mizuki Yamamoto, Kentaro Semba, Noritaka Yamaguchi, Tadashi Yamamoto, Motoharu Seiki, Jun-ichiro Inoue   +7 more
openalex   +2 more sources

Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise

Journal of Extracellular Vesicles, Volume 13, Issue 1, January 2024.
Abstract In healthy individuals, physical exercise improves cardiovascular health and muscle strength, alleviates fatigue and reduces the risk of chronic diseases. Although exercise is suggested as a lifestyle intervention to manage various chronic illnesses, it negatively affects people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS),
Ludovic Giloteaux, Katherine A. Glass, Arnaud Germain, Carl J. Franconi, Sheng Zhang, Maureen R. Hanson   +5 more
wiley   +1 more source