Results 121 to 130 of about 4,124 (226)

Leiomodins: Larger Members of the Tropomodulin (Tmod) Gene Family

Genomics, 2001
The 64-kDa autoantigen D1 or 1D, first identified as a potential autoantigen in Graves' disease, is similar to the tropomodulin (Tmod) family of actin filament pointed end-capping proteins. A novel gene with significant similarity to the 64-kDa human autoantigen D1 has been cloned from both humans and mice, and the genomic sequences of both genes have ...
C A, Conley, K L, Fritz-Six, A, Almenar-Queralt, V M, Fowler   +3 more
openaire   +2 more sources

Recessive TMOD1 mutation causes childhood cardiomyopathy

Communications Biology
Familial cardiomyopathy in pediatric stages is a poorly understood presentation of heart disease in children that is attributed to pathogenic mutations. Through exome sequencing, we report a homozygous variant in tropomodulin 1 (TMOD1; c.565C>T, p.R189W)
Catalina Vasilescu, Mert Colpan, Tiina H. Ojala, Tuula Manninen, Aino Mutka, Kaisa Ylänen, Otto Rahkonen, Tuija Poutanen, Laura Martelius, Reena Kumari, Helena Hinterding, Virginia Brilhante, Simo Ojanen, Pekka Lappalainen, Juha Koskenvuo, Christopher J. Carroll, Velia M. Fowler, Carol C. Gregorio, Anu Suomalainen   +18 more
doaj   +1 more source

An Always Correlated gene expression landscape for ovine skeletal muscle, lessons learnt from comparison with an “equivalent” bovine landscape [PDF]

, 2012
BACKGROUND: We have recently described a method for the construction of an informative gene expression correlation landscape for a single tissue, longissimus muscle (LM) of cattle, using a small number (less than a hundred) of diverse samples.
Antonio Reverter, Ashley J Waardenberg, Brian P Dalrymple, Keren Byrne, Nicholas J Hudson, Ross L Tellam, Tony Vuocolo, Wei Sun   +7 more
core   +1 more source

Tubules of plant reoviruses exploit tropomodulin to regulate actin-based tubule motility in insect vector

Scientific Reports, 2017
Plant reoviruses are known to exploit virion-packaging tubules formed by virus-encoding non-structural proteins for viral spread in insect vectors. Tubules are propelled by actin-based tubule motility (ABTM) to overcome membrane or tissue barriers in ...
Qian Chen, Linghua Zhang, Yanshuang Zhang, Qianzhuo Mao, T. Wei   +4 more
semanticscholar   +1 more source

Contemporary blood doping—Performance, mechanism, and detection

Scandinavian Journal of Medicine &Science in Sports, Volume 34, Issue 1, January 2024.
Abstract Blood doping is prohibited for athletes but has been a well‐described practice within endurance sports throughout the years. With improved direct and indirect detection methods, the practice has allegedly moved towards micro‐dosing, that is, reducing the blood doping regime amplitude.
Andreas Breenfeldt Andersen, Nikolai Baastrup Nordsborg, Thomas Christian Bonne, Jacob Bejder   +3 more
wiley   +1 more source

Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic [PDF]

, 2015
YesContext: Urinary biomarkers are promising as simple alternatives to cystoscopy for the diagnosis of de novo and recurrent bladder cancer. Objective: To identify a highly sensitive and specific biomarker candidate set with potential clinical utility ...
De Paoli, M., Feng, G.J., Lukas, A., Marquette, C., Morgan, Richard, Mühlberger, I., Pandha, H.S., Perco, P.   +7 more
core   +1 more source

Changes in the membrane proteome of human chronic kidney diseased erythrocytes [PDF]

, 2011
Comunicaciones a ...
Barderas, María G., Cuesta, Fernando de la, Ortiz, A., Ramos, A., Sanz, A., Vivanco, Fernando, Zubiri, Irene, Álvarez-Llamas, Gloria   +7 more
core  

Plasmodium falciparum infection induces dynamic changes in the erythrocyte phospho-proteome [PDF]

, 2016
The phosphorylation status of red blood cell proteins is strongly altered during the infection by the malaria parasite Plasmodium falciparum. We identify the key phosphorylation events that occur in the erythrocyte membrane and cytoskeleton during ...
Bouyer, Guillaume, D. Phillips, Lee, Egee, Stephane, Langsley, Gordon, Lasonder, Edwin, Ramdani, Ghania, Reininger, Luc, Sharma, Vikram   +7 more
core   +4 more sources

A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers [PDF]

, 2013
Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug that provokes tumor apoptosis are in demand; acquisition of longitudinal tumor
Brown, G., Brown, Gill, Cawthorne, C., Dawson, M. J., Dive, C., Dive, Caroline, Hodgkinson, C. L., Kadirvel, M., MacFarlane, M., Simpson, K. L., Trapani, F., Walker, M. J., Whetton, A. D., Williams, K. J., Zhou, C.   +14 more
core   +3 more sources

Nanomechanics of Multiple Units in the Erythrocyte Membrane Skeletal Network [PDF]

, 2010
Erythrocytes undergo deformations when they transport O(2) and CO(2) across the membrane, yet the 3D nanomechanics of the skeletal network remains poorly understood. Expanding from our previous single isolated unit, we now simulate networks consisting of
Carlos Vera, Lanping Amy Sung, Mauricio de Oliveira, Pierre Valdez, Robert Skelton, Yasha Sharma   +5 more
core   +3 more sources