Results 121 to 130 of about 76,365 (337)

Structural evidence of tropomyosin in purified smooth muscle thin filaments from chicken gizzard

Journal of Analytical Science and Technology
Tropomyosin is one of the key components involved in actin–myosin interactions, which are essential for muscle contraction and regulation of cytoskeletal dynamics.
Anahita Vispi Bharda, Yoon Ho Park, Hyuntae Hong, Young Kwan Kim, Hyun Suk Jung   +4 more
doaj   +1 more source

Assessing diagnostic tests for shrimp allergy in children: A multicenter trial

Journal of Allergy and Clinical Immunology: Global
Background: Clinical research on pediatric shrimp allergy is limited. Objective: We sought to evaluate the diagnostic accuracy and safety of testing methods for shrimp allergy.
Yuri Takaoka, MD, PhD, Yuki Tsurinaga, MD, Yukiko Hiraguchi, MD, PhD, Masaaki Hamada, MD, PhD, Atsuko Nakano, MD, Tomoko Kawakami, MD, Ikuo Okafuji, MD, PhD, Nayu Iwakoshi, MD, Masaaki Doi, MD, PhD, Keita Otsuka, MD, Yukiko Sugimoto, MD, Norihito Iba, MD, Junko Kumon, MD, Rumi Ueno, MD, Tamana Nakano, MD, Tomohiro Yamaguchi, MD, Yohei Fuksawa, MD, Amane Shigekawa, MD, Yukinori Yoshida, MD, PhD, Makoto Kameda, MD   +19 more
doaj   +1 more source

Potentiality in Biology [PDF]

, 2018
We take the potentialities that are studied in the biological sciences (e.g., totipotency) to be an important subtype of biological dispositions. The goal of this paper is twofold: first, we want to provide a detailed understanding of what biological ...
A Bird, A Hüttemann, A Hüttemann, AC Love, B Alberts, CF Craver, CF Craver, CF Craver, CR Townsend, D Lewis, DH Mellor, E Prior, G Molnar, J Frydman, J Mackie, J McKitrick, J Woodward, KF Schaffner, L Darden, L Darden, M Kirschner, N Cartwright, NA Campbell, P Machamer, R Carnap, RN Brandon, RN Brandon, S Glennan, S Mumford, S Mumford, SC Stearns, SD Mitchell, SD Mitchell, SF Gilbert, SK Mills, T Handfield, W Bechtel, W Bechtel   +37 more
core   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d) [PDF]

, 2006
Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species. Calpains play a role in cell differentiation, apoptosis, cytoskeletal remodeling, signal transduction and ...
Croall, Dayton, Fischer, Fuchs, Goll, Harris, Inomata, Kuboki, Lee, Molinari, Nicotera, Ruas, Sasaki, Smialowski   +13 more
core   +2 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks

eLife, 2017
The fission yeast actin cytoskeleton is an ideal, simplified system to investigate fundamental mechanisms behind cellular self-organization. By focusing on the stabilizing protein tropomyosin Cdc8, bundling protein fimbrin Fim1, and severing protein ...
Jenna R Christensen, Glen M Hocky, Kaitlin E Homa, Alisha N Morganthaler, Sarah E Hitchcock-DeGregori, Gregory A Voth, David R Kovar   +6 more
doaj   +1 more source

A Stochastic Multiscale Model of Cardiac Thin Filament Activation Using Brownian-Langevin Dynamics. [PDF]

, 2019
We use Brownian-Langevin dynamics principles to derive a coarse-graining multiscale myofilament model that can describe the thin-filament activation process during contraction.
Aboelkassem, Yasser, Huber, Gary A, McCabe, Kimberly J, McCammon, J Andrew, McCulloch, Andrew D, Regnier, Michael   +5 more
core  

Amino Acid Changes at Arginine 204 of Troponin I Result in Increased Calcium Sensitivity of Force Development. [PDF]

, 2016
Mutations in human cardiac troponin I (cTnI) have been associated with restrictive, dilated, and hypertrophic cardiomyopathies. The most commonly occurring residue on cTnI associated with familial hypertrophic cardiomyopathy (FHC) is arginine (R), which ...
Cui, Ziyou, Dewey, Shannamar, Gomes, Aldrin V, Nguyen, Susan, Siu, Rylie   +4 more
core   +2 more sources

Precision medicine in cutaneous melanoma—A comprehensive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Precision medicine tailors treatment to each patient, beginning with detailed diagnostics. In melanoma, it has advanced considerably: Some methods are in practice and guidelines, while others are commercially available but not routine. This review highlights current and emerging approaches, including molecular profiling, imaging, biomarkers and AI ...
Markus Reitmajer, Lukas Flatz
wiley   +1 more source