Results 21 to 30 of about 88,882 (294)
Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates. [PDF]
The contractile response of the heart can be altered by disease-related protein modifications to numerous contractile proteins. By utilizing an IAANS labeled fluorescent troponin C, [Formula: see text], we examined the effects of ten disease-related ...
Bin Liu+4 more
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Structural dynamics of calmodulin and troponin C [PDF]
We present the results of computational simulation studies of the structures of calmodulin (CAM) and troponin C (TNC). Possible differences between the structures of these molecules in the crystal and in solution were suggested by results from some recent experimental studies, which implied that their conformations in solution may be more compacted ...
Mehler, Ernest L.+2 more
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BackgroundThe treatment of myopericarditis is different than that of acute myocardial infarction (AMI). However, since their clinical presentation is frequently similar it may be difficult to distinguish between these entities despite a disparate ...
Simcha R Meisel+13 more
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Characterization of a Cardiac Troponin C-Troponin I Chimera Protein [PDF]
Association of the regulatory N-domain of cardiac troponin C (cNTnC) with the switch region of cardiac troponin I (cTnI147-163) is a major step in Ca2+ regulation of myocardial contraction by troponin as it triggers a series of downstream events that leads to contraction.
Sandra E. Pineda-Sanabria+3 more
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Analysis of myofibrillar and sarcoplasmic proteins in pork meat by capillary gel electrophoresis
Myofibrillar and sarcoplasmic proteins were extracted from pork meat (M. Longissimus dorsi) and then separated by capillary gel electrophoresis (CGE). Migration time and peak areas of individual protein molecules in the electropherogram were analysed ...
Radoslav Grujić, Danica Savanović
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Evaluation of troponin I and C in horses intoxicated by salinomycin
: Ionophores are antibiotics frequently used in animals of production. The most common are monensin, salinomycin, narasin, and lasalocid. The equine species is highly susceptible to ionophores poisoning.
Camila B. Pohl+7 more
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Irisin regulates cardiac physiology in zebrafish.
Irisin is a myokine encoded in its precursor fibronectin type III domain containing 5 (FNDC5). It is abundantly expressed in cardiac and skeletal muscle, and is secreted upon the activation of peroxisome proliferator-activated receptor gamma coactivator ...
Lakshminarasimhan Sundarrajan+4 more
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Familial hypertrophic cardiomyopathy related cardiac troponin C L29Q mutation alters length-dependent activation and functional effects of phosphomimetic troponin I*. [PDF]
The Ca(2+) binding properties of the FHC-associated cardiac troponin C (cTnC) mutation L29Q were examined in isolated cTnC, troponin complexes, reconstituted thin filament preparations, and skinned cardiomyocytes. While higher Ca(2+) binding affinity was
Alison Y Li+6 more
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Aluminum fluoride interactions with troponin C
The increasing interest in the metal ion aluminum fluoride and beryllium fluoride complexes as phosphate analogs in the myosin ATPase reaction and in muscle fiber studies prompted the examination of their interactions with the regulatory system of troponin and tropomyosin.
Emil Reisler, B.C. Phan
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Drug Binding to Cardiac Troponin C [PDF]
Compounds that sensitize cardiac muscle to Ca(2+) by intervening at the level of regulatory thin filament proteins would have potential therapeutic benefit in the treatment of myocardial infarctions. Two putative Ca(2+) sensitizers, EMD 57033 and levosimendan, are reported to bind to cardiac troponin C (cTnC).
John A. Putkey, Quinn Kleerekoper
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