Results 21 to 30 of about 88,882 (294)

Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates. [PDF]

PLoS ONE, 2012
The contractile response of the heart can be altered by disease-related protein modifications to numerous contractile proteins. By utilizing an IAANS labeled fluorescent troponin C, [Formula: see text], we examined the effects of ten disease-related ...
Bin Liu, Svetlana B Tikunova, Kristopher P Kline, Jalal K Siddiqui, Jonathan P Davis   +4 more
doaj   +1 more source

Structural dynamics of calmodulin and troponin C [PDF]

"Protein Engineering, Design and Selection", 1991
We present the results of computational simulation studies of the structures of calmodulin (CAM) and troponin C (TNC). Possible differences between the structures of these molecules in the crystal and in solution were suggested by results from some recent experimental studies, which implied that their conformations in solution may be more compacted ...
Mehler, Ernest L., Pascual-Ahuir, Juan-Luis, Weinstein, Harel   +2 more
openaire   +3 more sources

Differentiation between myopericarditis and acute myocardial infarction on presentation in the emergency department using the admission C-reactive protein to troponin ratio.

PLoS ONE, 2021
BackgroundThe treatment of myopericarditis is different than that of acute myocardial infarction (AMI). However, since their clinical presentation is frequently similar it may be difficult to distinguish between these entities despite a disparate ...
Simcha R Meisel, Hamuda Nashed, Randa Natour, Rami Abu Fanne, Majdi Saada, Naama Amsalem, Carmel Levin, Ofer Kobo, Aaron Frimerman, Yaniv Levi, Jameel Mohsen, Avraham Shotan, Ariel Roguin, Michael Kleiner-Shochat   +13 more
doaj   +1 more source

Characterization of a Cardiac Troponin C-Troponin I Chimera Protein [PDF]

Biophysical Journal, 2013
Association of the regulatory N-domain of cardiac troponin C (cNTnC) with the switch region of cardiac troponin I (cTnI147-163) is a major step in Ca2+ regulation of myocardial contraction by troponin as it triggers a series of downstream events that leads to contraction.
Sandra E. Pineda-Sanabria, Monica X. Li, Olivier Julien, Brian D. Sykes   +3 more
openaire   +2 more sources

Analysis of myofibrillar and sarcoplasmic proteins in pork meat by capillary gel electrophoresis

Foods and Raw Materials, 2018
Myofibrillar and sarcoplasmic proteins were extracted from pork meat (M. Longissimus dorsi) and then separated by capillary gel electrophoresis (CGE). Migration time and peak areas of individual protein molecules in the electropherogram were analysed ...
Radoslav Grujić, Danica Savanović
doaj   +1 more source

Evaluation of troponin I and C in horses intoxicated by salinomycin

Pesquisa Veterinária Brasileira, 2023
: Ionophores are antibiotics frequently used in animals of production. The most common are monensin, salinomycin, narasin, and lasalocid. The equine species is highly susceptible to ionophores poisoning.
Camila B. Pohl, Bianca S. Cecco, Luan C. Henker, Marcele B. Bandinelli, Ronaldo M. Bianchi, Welden Panziera, Saulo P. Pavarini, David Driemeier   +7 more
doaj   +1 more source

Irisin regulates cardiac physiology in zebrafish.

PLoS ONE, 2017
Irisin is a myokine encoded in its precursor fibronectin type III domain containing 5 (FNDC5). It is abundantly expressed in cardiac and skeletal muscle, and is secreted upon the activation of peroxisome proliferator-activated receptor gamma coactivator ...
Lakshminarasimhan Sundarrajan, Chanel Yeung, Logan Hahn, Lynn P Weber, Suraj Unniappan   +4 more
doaj   +1 more source

Familial hypertrophic cardiomyopathy related cardiac troponin C L29Q mutation alters length-dependent activation and functional effects of phosphomimetic troponin I*. [PDF]

PLoS ONE, 2013
The Ca(2+) binding properties of the FHC-associated cardiac troponin C (cTnC) mutation L29Q were examined in isolated cTnC, troponin complexes, reconstituted thin filament preparations, and skinned cardiomyocytes. While higher Ca(2+) binding affinity was
Alison Y Li, Charles M Stevens, Bo Liang, Kaveh Rayani, Sean Little, Jonathan Davis, Glen F Tibbits   +6 more
doaj   +1 more source

Aluminum fluoride interactions with troponin C

Biophysical Journal, 1993
The increasing interest in the metal ion aluminum fluoride and beryllium fluoride complexes as phosphate analogs in the myosin ATPase reaction and in muscle fiber studies prompted the examination of their interactions with the regulatory system of troponin and tropomyosin.
Emil Reisler, B.C. Phan
openaire   +3 more sources

Drug Binding to Cardiac Troponin C [PDF]

Journal of Biological Chemistry, 1999
Compounds that sensitize cardiac muscle to Ca(2+) by intervening at the level of regulatory thin filament proteins would have potential therapeutic benefit in the treatment of myocardial infarctions. Two putative Ca(2+) sensitizers, EMD 57033 and levosimendan, are reported to bind to cardiac troponin C (cTnC).
John A. Putkey, Quinn Kleerekoper
openaire   +3 more sources