Results 71 to 80 of about 88,882 (294)

Coarse-Grained Modeling of Peptide Docking Associated with Large Conformation Transitions of the Binding Protein: Troponin I Fragment–Troponin C System

Molecules, 2015
Most of the current docking procedures are focused on fine conformational adjustments of assembled complexes and fail to reproduce large-scale protein motion. In this paper, we test a new modeling approach developed to address this problem.
Jacek Wabik, Mateusz Kurcinski, Andrzej Kolinski   +2 more
doaj   +1 more source

Mouse Models of Cardiomyopathies Caused by Mutations in Troponin C. [PDF]

Int J Mol Sci, 2023
Tikunova SB, Thuma J, Davis JP.
europepmc   +1 more source

Stent Fracture of Biolimus‐Eluting Stent (Biofreedom) Complicated With Micro‐Coronary Artery Aneurysm

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Coronary stent fractures (SFs) are an emerging complication of coronary stents. There are numerous risk factors for SF, which include vessel angulation, use of sirolimus‐eluting stent (SES), long stents, multiple stent layers, stent overlap, inflammation, hypersensitivity, stenting in the right coronary artery, heavy calcification, ostial ...
Kosuke Muto, Takahide Arai, Hiroki Hoya, Shintaro Nakano   +3 more
wiley   +1 more source

Plant proteases and anti-bacterial substances in Allium sativum L. varieties

Foods and Raw Materials
Allium sativum L. protease still remains largely understudied although new varieties of garlic appear quite often, e.g., lanang garlic. This study tested the antibacterial effect of garlic and the effectiveness of various A.
Budianto Budianto, Muh Jaenal Arifin, Naryani Naryani, Endah Sukmawati, Suwaji Suwaji, Tri Handoko Moedji Wibowo, Syahilla Vanda Luviana, Lia Dekryt Vergiana Putri   +7 more
doaj   +1 more source

Infantile restrictive cardiomyopathy: cTnI-R170G/W impair the interplay of sarcomeric proteins and the integrity of thin filaments.

PLoS ONE, 2020
TNNI3 encoding cTnI, the inhibitory subunit of the troponin complex, is the main target for mutations leading to restrictive cardiomyopathy (RCM). Here we investigate two cTnI-R170G/W amino acid replacements, identified in infantile RCM patients, which ...
Diana Cimiotti, Setsuko Fujita-Becker, Desirée Möhner, Natalia Smolina, Heidi Budde, Aline Wies, Lisa Morgenstern, Alexandra Gudkova, Thomas Sejersen, Gunnar Sjöberg, Andreas Mügge, Marc M Nowaczyk, Peter Reusch, Gabriele Pfitzer, Robert Stehle, Rasmus R Schröder, Hans G Mannherz, Anna Kostareva, Kornelia Jaquet   +18 more
doaj   +1 more source

YTnC2, an improved genetically encoded green calcium indicator based on toadfish troponin C. [PDF]

FEBS Open Bio, 2023
Subach OM, Vlaskina AV, Agapova YK, Nikolaeva AY, Varizhuk AM, Podgorny OV, Piatkevich KD, Patrushev MV, Boyko KM, Subach FV.   +9 more
europepmc   +1 more source

DCM troponin C mutant Gly159Asp blunts the response to troponin phosphorylation

Biochemical and Biophysical Research Communications, 2007
Dilated cardiomyopathy (DCM) can be caused by a Gly159Asp mutation in cardiac troponin C (cTnC). Our previous work found that partial replacement of endogenous troponin in skinned muscle fibres with human cardiac troponin containing Gly159Asp cTnC had no significant effect on maximum force generation, Ca(2+)-sensitivity or cooperativity, but halved the
Preston, L, Ashley, C, Redwood, C
openaire   +4 more sources

A Rare Case of Nitroglycerin Resistant Coronary Arterial Vasospasm During Coronary Artery Bypass Surgery

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Coronary artery vasospasm following coronary artery bypass grafting (CABG) is a rare but potentially life‐threatening complication that can lead to myocardial ischemia, arrhythmias, and cardiogenic shock. Nitroglycerin‐resistant vasospasm, particularly involving the left main coronary artery (LMCA), poses significant diagnostic and ...
Dina Soliman, Cristian Castillo‐Rodriguez, Diego Cruz, John Abdelmalek   +3 more
wiley   +1 more source

Computational Exploration and Characterization of Potential Calcium Sensitizing Mutations in Cardiac Troponin C. [PDF]

J Chem Inf Model, 2022
Hantz ER, Lindert S.
europepmc   +1 more source

Increased Thrombogenicity is Associated With Coronary Microvascular Dysfunction in Patients With STEMI—A Proof‐of‐Concept Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Up to 50% of patients with ST‐segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) develop coronary microvascular dysfunction (CMD). Aims This study aims to assess whether a prothrombotic state of coronary blood, defined by thromboelastography (TEG), is associated with post ...
Roberto Scarsini, Denis Leonardi, Andrea Bottardi, Concetta Mammone, Leonardo Portolan, Caterina Butturini, Verdiana Galli, Francesco Della Mora, Alessandro Ruzzarin, Sara Pazzi, Anna Piccoli, Simone Fezzi, Domenico Tavella, Gabriele Pesarini, Leonardo Gottin, Flavio Ribichini   +15 more
wiley   +1 more source