Results 31 to 40 of about 43,375 (307)

Crystal structure of troponin C in complex with troponin I fragment at 2.3-Å resolution [PDF]

Proceedings of the National Academy of Sciences, 1998
Troponin (Tn), the complex of three subunits (TnC, TnI, and TnT), plays a key role in Ca 2+ -dependent regulation of muscle contraction. To elucidate the interactions between the Tn subunits and the conformation of TnC in the Tn complex, we have determined the crystal structure of TnC (two Ca 2+
Kayo Maeda, Soichi Wakatsuki, Yuichiro Maéda, Dmitry G. Vassylyev, Soichi Takeda   +4 more
openaire   +3 more sources

Modeling Human Cardiac Thin Filament Structures

Frontiers in Physiology, 2022
Striated muscle contraction is regulated in a calcium-dependent manner through dynamic motions of the tropomyosin/troponin polymer, a multicomponent complex wrapped around actin-containing thin filaments.
Michael J. Rynkiewicz, Elumalai Pavadai, William Lehman   +2 more
doaj   +1 more source

Crosstalk within Cardiac Troponin Complex with the R145W Mutation in Cardiac Troponin I [PDF]

Biophysical Journal, 2016
The cardiac troponin I (cTnI) inhibitory peptide (IPcTnI) and N-terminal domains (NtcTnI) both regulate the affinity of troponin C (cTnC) to Ca2+ being substrates for protein kinases -C (PKC; T143) and -A (PKA; S23/24), respectively. The R145W mutation localized next to the T143 site has been linked to the development of restrictive cardiomyopathy (RCM)
Alexey V. Dvornikov, Jodi L. Martin, Nikolai Smolin, Seth L. Robia, Pieter P. de Tombe   +4 more
openaire   +2 more sources

Phosphorylation of troponin and the effects of interactions between the components of the complex [PDF]

Biochemical Journal, 1974
1. The troponin complex from skeletal muscle contains approximately 1 mol of phosphate/80000g of complex, covalently bound to the troponin T component. 2. On prolonged incubation of the troponin complex or troponin T with phosphorylase kinase the phosphate content of troponin T was increased to approx. 3mol/mol. 3. On prolonged incubation of troponin I
S. V. Perry, H. A. Cole
openaire   +4 more sources

Prognostically Significant Myocardial Injury in Patients Undergoing Transcatheter Aortic Valve Replacement

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Troponin elevation occurs commonly in the setting of transcatheter aortic valve replacement (TAVR). There is a lack of information on the extent of troponin elevation post TAVR that is prognostically significant. We assessed the optimal cutoff
Vikram Sharma, Tanujit Dey, Kesavan Sankaramangalam, Shehab A. R. Alansari, Louis Williams, Stephanie Mick, Amar Krishnaswamy, Lars G. Svensson, Samir Kapadia   +8 more
doaj   +1 more source

The Solution Structure of a Cardiac Troponin C−Troponin I−Troponin T Complex Shows a Somewhat Compact Troponin C Interacting with an Extended Troponin I−Troponin T Component [PDF]

Biochemistry, 2002
We have investigated the structure of the cTnC-cTnI-cTnT(198-298) calcium-saturated, ternary cardiac troponin complex by small-angle scattering with contrast variation. Shape restoration was also applied to the scattering information resulting from the deuterated cTnC subunit, the unlabeled cTnI-cTnT(198-298) subunits, and the entire complex.
Paul R. Rosevear, William T. Heller, Jill Trewhella, Natosha Finley, Ekram Abusamhadneh   +4 more
openaire   +3 more sources

Clinical Biochemistry of Serum Troponin

Diagnostics
Accurate measurement and interpretation of serum levels of troponin (Tn) is a central part of the clinical workup of a patient presenting with chest pain suspicious for acute coronary syndrome (ACS).
Ilhan Gokhan, Weilai Dong, Daniel Grubman, Kenechukwu Mezue, David Yang, Yanting Wang, Parul U. Gandhi, Jennifer M. Kwan, Jiun-Ruey Hu   +8 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Abnormal elevation of myocardial necrosis biomarkers after coronary artery bypass grafting without established myocardial infarction assessed by cardiac magnetic resonance

Journal of Cardiothoracic Surgery, 2017
Background The diagnosis of peri-procedural myocardial infarction is complex, especially after the emergence of high-sensitivity markers of myocardial necrosis. Methods In this study, patients with normal baseline cardiac biomarkers and formal indication
Fernando Teiichi Costa Oikawa, Whady Hueb, Cesar Higa Nomura, Alexandre Ciappina Hueb, Alexandre Volney Villa, Leandro Menezes Alves da Costa, Rodrigo Morel Vieira de Melo, Paulo Cury Rezende, Carlos Alexandre Wainrober Segre, Cibele Larrosa Garzillo, Eduardo Gomes Lima, Jose Antonio Franchini Ramires, Roberto Kalil Filho   +12 more
doaj   +1 more source

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

Advanced Functional Materials, EarlyView.
In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García, María Flandes‐Iparraguirre, Pilar Montero‐Calle, Ricardo M. Rosales, Asier Ullate‐Agote, Andrea Sánchez‐Bueno, Eduardo Larequi, Ilazki Anaut‐Lusar, Nicolás Laita, Aida Oliván‐Viguera, Elena Iglesias, Gloria Abizanda, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Xabier L. Aranguren, Manuel García de Yébenes, Juan José Gavira, Miguel Ángel Martínez, Estefanía Peña, Manuel Doblaré, Elena M. de‐Juan‐Pardo, Esther Pueyo, Felipe Prosper, Manuel M. Mazo Vega   +23 more
wiley   +1 more source