Distance distributions and anisotropy decays of troponin C and its complex with troponin I [PDF]
Biochemistry, 1991 We used frequency domain measurements of fluorescence resonance energy transfer to recover the distribution of distances between Met 25 and Cys 98 in rabbit skeletal troponin C. These residues were labeled with dansylaziridine as energy donor and 5-(iodoacetamido)eosin as acceptor and are located on the N- and C-terminal lobes of the two-domain protein,
Wiesław Wiczk +6 more
openaire +3 more sources
Biosensors for cardiac biomarkers detection: a review [PDF]
, 2012 The cardiovascular disease (CVD) is considered as a major threat to global health. Therefore, there is a growing demand for a range of portable, rapid and low cost biosensing devices for the detection of CVD.
Gurbuz, Yasar +3 more
core +1 more source
Computational Studies of Cardiac and Skeletal Troponin
Frontiers in Molecular Biosciences, 2019 Troponin is a key regulatory protein in muscle contraction, consisting of three subunits troponin C (TnC), troponin I (TnI), and troponin T (TnT). Calcium association to TnC initiates contraction by causing a series of dynamic and conformational changes ...
Jacob D. Bowman, Steffen Lindert
doaj +1 more source
Troponin T3 regulates nuclear localization of the calcium channel Cavβ1a subunit in skeletal muscle [PDF]
, 2015 The voltage-gated calcium channel (Cav) β1a subunit (Cavβ1a) plays an important role in excitation-contraction coupling (ECC), a process in the myoplasm that leads to muscle-force generation. Recently, we discovered that the Cavβ1a subunit travels to the
Delbono, Osvaldo +7 more
core +2 more sources
Journal of Health Sciences, 2011 Introduction: The aim of this study was determination of troponin I at serum using Architect (Abbott) and AxSYM System (Abbott). Troponin is regulatory subunit of the troponin complex associate with actin filament within muscle cells and it is a marker ...
Nafija Serdarević
doaj +1 more source
A Case Series of Disproportionate Elevations of Cardiac Troponin and Macrotroponin in Fabry Disease [PDF]
Journal of Inborn Errors of Metabolism and ScreeningFabry disease is a rare X-linked lysosomal storage disorder that causes progressive cellular accumulation of glycosphingolipids, leading to various end-organ manifestations such as chronic kidney disease and cardiomyopathy.
Yvonne Moussa +5 more
doaj +1 more source
Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin. [PDF]
PLoS ONE, 2013 Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) lead to significant cardiovascular morbidity and mortality worldwide. Mutations in the genes encoding the sarcomere, the force-generating unit in the cardiomyocyte, cause familial forms ...
Ruth F Sommese +5 more
doaj +1 more source
The calcium‐induced switch in the troponin complex probed by fluorescent mutants of troponin I [PDF]
European Journal of Biochemistry, 2003 The Ca2+‐induced transition in the troponin complex (Tn) regulates vertebrate striated muscle contraction. Tn was reconstituted with recombinant forms of troponin I (TnI) containing a single intrinsic 5‐hydroxytryptophan (5HW). Fluorescence analysis of these mutants of TnI demonstrate that the regions in TnI that respond to Ca2+ binding to the ...
Deodoro Camargo Silva Gonçalves de Oliveira +1 more
openaire +3 more sources
Utility of B-type natriuretic peptide in predicting medium-term mortality in patients undergoing major non-cardiac surgery [PDF]
, 2007 We assessed the ability of pre-operative B-type natriuretic peptide (BNP) levels to predict medium-term mortality in patients undergoing major noncardiac surgery.
Amiri, Amir R. +5 more
core +1 more source
Bovine cardiac troponin subunits: binary complexes and reconstitution of whole troponin
FEBS Letters, 1982 The reconstitution of bovine cardiac troponin from its subunits has been investigated using hydrodynamic techniques. Gel filtration (Sephacryl S‐300) and sedimentation velocity experiments indicate that troponin‐C and troponin‐I from a stable binary complex (1:1 mole ratio) with an apparent Stokes' radius of 36 Å (frictional ratio = 1.6).
David M. Byers, Cyril M. Kay
openaire +3 more sources