Results 61 to 70 of about 6,764,388 (368)
The 99th percentile of reference population for cTnI and cTnT assay: Methodology, pathophysiology and clinical implications [PDF]
, 2017 According to recent international guidelines, including the 2012 Third Universal Definiton of Myocardial Infarction by the Joint ESC/ACCF/AHA/WHF Task Force, an increase in cardiac troponin (cTn) levels over the 99th percentile upper reference limit ...
Clerico, Aldo +6 more
core +1 more source
Calcium induced regulation of skeletal troponin--computational insights from molecular dynamics simulations. [PDF]
PLoS ONE, 2013 The interaction between calcium and the regulatory site(s) of striated muscle regulatory protein troponin switches on and off muscle contraction. In skeletal troponin binding of calcium to sites I and II of the TnC subunit results in a set of structural ...
Georgi Z Genchev +2 more
doaj +1 more source
HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation [PDF]
, 2020 Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Allen, George F. G. +4 more
core +3 more sources
Modeling Human Cardiac Thin Filament Structures
Frontiers in Physiology, 2022 Striated muscle contraction is regulated in a calcium-dependent manner through dynamic motions of the tropomyosin/troponin polymer, a multicomponent complex wrapped around actin-containing thin filaments.
Michael J. Rynkiewicz +2 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Troponin elevation occurs commonly in the setting of transcatheter aortic valve replacement (TAVR). There is a lack of information on the extent of troponin elevation post TAVR that is prognostically significant. We assessed the optimal cutoff
Vikram Sharma +8 more
doaj +1 more source
Development of Optical Biosensor Technologies for Cardiac Troponin Recognition [PDF]
, 2015 Acute myocardial infarction (AMI) is the leading cause of death among cardiovascular diseases. Among the numerous attempts to develop coronary marker concepts into clinical strategies, cardiac troponin is known as a specific marker for coronary events ...
Abdolrahim, Mojgan +5 more
core +1 more source
Utility of B-type natriuretic peptide in predicting medium-term mortality in patients undergoing major non-cardiac surgery [PDF]
, 2007 We assessed the ability of pre-operative B-type natriuretic peptide (BNP) levels to predict medium-term mortality in patients undergoing major noncardiac surgery.
Amiri, Amir R. +5 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu +5 more
wiley +1 more source
Crosstalk within Cardiac Troponin Complex with the R145W Mutation in Cardiac Troponin I [PDF]
Biophysical Journal, 2016 The cardiac troponin I (cTnI) inhibitory peptide (IPcTnI) and N-terminal domains (NtcTnI) both regulate the affinity of troponin C (cTnC) to Ca2+ being substrates for protein kinases -C (PKC; T143) and -A (PKA; S23/24), respectively. The R145W mutation localized next to the T143 site has been linked to the development of restrictive cardiomyopathy (RCM)
Smolin, Nikolai +4 more
openaire +1 more source
Advanced Functional Materials, EarlyView.This review highlights recent advances in label‐free optical biosensors based on 2D materials and rationally designed mixed‐dimensional nanohybrids, emphasizing their synergistic effects and novel functionalities. It also discusses multifunctional sensing platforms and the integration of machine learning for intelligent data analysis.
Xinyi Li, Yonghao Fu, Yuehe Lin, Dan Du
wiley +1 more source