The implementation of persuasive technology principles in mobile application development: a qualitative study [PDF]
, 2012 Preceding studies of persuasive technology have mentioned several benefits on the implementation of persuasive design features of the Persuasive System Design (PSD) model such as creating users' engagement and acceptance and continuous usage.
Abd Rahim, Mohd Hilmi Izwan +4 more
core +3 more sources
Modeling Human Cardiac Thin Filament Structures
Frontiers in Physiology, 2022 Striated muscle contraction is regulated in a calcium-dependent manner through dynamic motions of the tropomyosin/troponin polymer, a multicomponent complex wrapped around actin-containing thin filaments.
Michael J. Rynkiewicz +2 more
doaj +1 more source
Tissue-specific interactions of TNI isoforms with other TN subunits and tropomyosins in C. elegans: The role of the C- and N-terminal extensions [PDF]
, 2007 The aim of this study is to investigate the function of the C-terminal extension of three troponin I isoforms, that are unique to the body wall muscles of Caenorhabditis elegans and to understand the molecular interactions within the TN complex between ...
al-Hillawi +35 more
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Bovine cardiac troponin subunits: binary complexes and reconstitution of whole troponin
FEBS Letters, 1982 The reconstitution of bovine cardiac troponin from its subunits has been investigated using hydrodynamic techniques. Gel filtration (Sephacryl S‐300) and sedimentation velocity experiments indicate that troponin‐C and troponin‐I from a stable binary complex (1:1 mole ratio) with an apparent Stokes' radius of 36 Å (frictional ratio = 1.6).
David M. Byers, Cyril M. Kay
openaire +3 more sources
Calcium induced regulation of skeletal troponin--computational insights from molecular dynamics simulations. [PDF]
PLoS ONE, 2013 The interaction between calcium and the regulatory site(s) of striated muscle regulatory protein troponin switches on and off muscle contraction. In skeletal troponin binding of calcium to sites I and II of the TnC subunit results in a set of structural ...
Georgi Z Genchev +2 more
doaj +1 more source
Crystal structure of troponin C in complex with troponin I fragment at 2.3-Å resolution [PDF]
Proceedings of the National Academy of Sciences, 1998 Troponin (Tn), the complex of three subunits (TnC, TnI, and TnT), plays a key role in Ca 2+ -dependent regulation of muscle contraction. To elucidate the interactions between the Tn subunits and the conformation of TnC in the Tn complex, we have determined the crystal structure of TnC (two Ca 2+
Kayo Maeda +4 more
openaire +3 more sources
The side chain of glutamine 13 is the acyl-donor amino acid modified by type 2 transglutaminase in subunit T of the native rabbit skeletal muscle troponin complex. [PDF]
, 2013 Subunit T of the native muscle troponin complex is a recognised substrate of transglutaminase both in vitro and in situ with formation of isopeptide bonds.
B. Ura +9 more
core +1 more source
Crosstalk within Cardiac Troponin Complex with the R145W Mutation in Cardiac Troponin I [PDF]
Biophysical Journal, 2016 The cardiac troponin I (cTnI) inhibitory peptide (IPcTnI) and N-terminal domains (NtcTnI) both regulate the affinity of troponin C (cTnC) to Ca2+ being substrates for protein kinases -C (PKC; T143) and -A (PKA; S23/24), respectively. The R145W mutation localized next to the T143 site has been linked to the development of restrictive cardiomyopathy (RCM)
Alexey V. Dvornikov +4 more
openaire +2 more sources
The cardiac Ca-sensitive regulatory switch, a system in dynamic equilibrium [PDF]
, 2008 The Ca-sensitive regulatory switch of cardiac muscle is a paradigmatic example of protein assemblies that communicate ligand binding through allosteric change. The switch is a dimeric complex of troponin C (TnC), an allosteric sensor for Ca, and troponin I (TnI), an allosteric reporter.
arxiv +1 more source
ST2 and Multimarker Testing in Acute Decompensated Heart Failure [PDF]
, 2015 Most data on heart failure biomarkers have been derived from patient cohorts with chronic disease. However, risk prediction in patients admitted with acute decompensated heart failure (ADHF) remains a challenge.
Antoni, Md +7 more
core +1 more source