Results 161 to 170 of about 52,480 (256)

Relationship between vancomycin-induced nephrotoxicity and vancomycin trough concentration in older adults: A retrospective observational study.

Indian J Pharmacol, 2023
Dai N, Jiang C, Wang Y.
europepmc   +1 more source

Ustekinumab trough concentration affects clinical and endoscopic outcomes in patients with refractory Crohn's disease: a Chinese real-world study. [PDF]

BMC Gastroenterol, 2021
Yao JY, Zhang M, Wang W, Peng X, Zhao JZ, Liu T, Li ZW, Sun HT, Hu P, Zhi M.   +9 more
europepmc   +1 more source

Direct Observation of Vortex Liquid Droplets in the Iron Pnictide Superconductor CaKFe4As4 at 0.5Tc

Advanced Science, EarlyView.
Vortex matter in the iron‐based superconductor CaKFe4As4${\rm CaKFe}_4{\rm As}_4$ is visualized at the nanoscale, revealing the unexpected emergence of vortex‐liquid droplets far below the critical temperature. These localized fluctuating regions coexist with a vortex solid, demonstrating that dissipation‐related dynamics arise well before macroscopic ...
Óscar Bou Marqués, Jose A. Moreno, Pablo García Talavera, Mingyu Xu, Juan Schmidt, Sergey L. Bud'ko, Paul C. Canfield, Isabel Guillamón, Edwin Herrera, Hermann Suderow   +9 more
wiley   +1 more source

Factors Affecting Vancomycin Trough Concentration; a Population Pharmacokinetic Model in Non-Critical Care Saudi Patients. [PDF]

Drug Des Devel Ther
Alqurain AA, Alrashidi LN, Aloraifej SK, Alkhalifah M, Alsayed HA, Abohelaika S, Alshabeeb MA, Aldhafeeri AS, Almuslim M, Bumozah TN, Alomar MJ, Alshehab AA, Alamer AA, Al-Matouq J, Bidasee KR, Alomar FA.   +15 more
europepmc   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Monitoring of the trough concentration of valproic acid in pediatric epilepsy patients: a machine learning-based ensemble model. [PDF]

Front Pharmacol
Chen YW, Lin XK, Chen S, Zhang YL, Wu W, Huang C, Rao X, Lu ZX, Liu ZJ.   +8 more
europepmc   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

The Role of Plasma Trough Concentration of Voriconazole and Voriconazole N-Oxide in Its Hepatotoxicity in Adult Patients. [PDF]

Drug Des Devel Ther
Cheng L, You X, Wang X, Yu M, Jia C.
europepmc   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source