Results 251 to 260 of about 176,809 (302)
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Current Opinion in Pharmacology, 2015
Evidence is accumulating on the role of transient receptor potential (TRP) channels, namely TRPV1, TRPA1, TRPV4 and TRPM8, expressed by C- and Aδ-fibres primary sensory neurons, in cough mechanism. Selective stimuli for these channels have been proven to provoke and, more rarely, to inhibit cough.
BENEMEI, SILVIA +3 more
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Evidence is accumulating on the role of transient receptor potential (TRP) channels, namely TRPV1, TRPA1, TRPV4 and TRPM8, expressed by C- and Aδ-fibres primary sensory neurons, in cough mechanism. Selective stimuli for these channels have been proven to provoke and, more rarely, to inhibit cough.
BENEMEI, SILVIA +3 more
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TRP Channels and Analgesia [PDF]
Life Sciences, 2013 Since cloning and characterizing the first nociceptive ion channel Transient Receptor Potential (TRP) Vanilloid 1 (TRPV1), other TRP channels involved in nociception have been cloned and characterized, which include TRP Vanilloid 2 (TRPV2), TRP Vanilloid 3 (TRPV3), TRP Vanilloid 4 (TRPV4), TRP Ankyrin 1 (TRPA1) and TRP Melastatin 8 (TRPM8), more ...
Louis S Premkumar
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TRP channels and mice deficient in TRP channels
Pflügers Archiv - European Journal of Physiology, 2005Transient receptor potential (TRP) channels are a superfamily of functionally versatile cation-permeant ion channels present in almost all mammalian cell types. Although they were initially proposed as store-operated calcium channels, recent progress shows that they exhibit a variety of regulatory and functional themes.
Bimal N, Desai, David E, Clapham
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2014
Pain usually occurs as a result of tissue damage and has a role in healing and protection. However, in certain conditions it has no functional purpose and can become chronic and debilitating. A demand for more effective treatments to deal with this highly prevalent problem requires a better understanding of the underlying mechanisms.
Jane E, Sexton +2 more
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Pain usually occurs as a result of tissue damage and has a role in healing and protection. However, in certain conditions it has no functional purpose and can become chronic and debilitating. A demand for more effective treatments to deal with this highly prevalent problem requires a better understanding of the underlying mechanisms.
Jane E, Sexton +2 more
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2014
Hearing is a particularly sensitive form of mechanosensation that relies on dedicated ion channels transducing sound-induced vibrations that hardly exceed Brownian motion. Attempts to molecularly identify these auditory transduction channels have put the focus on TRPs in ears.
Damiano, Zanini, Martin C, Göpfert
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Hearing is a particularly sensitive form of mechanosensation that relies on dedicated ion channels transducing sound-induced vibrations that hardly exceed Brownian motion. Attempts to molecularly identify these auditory transduction channels have put the focus on TRPs in ears.
Damiano, Zanini, Martin C, Göpfert
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2012
The Transient receptor potential (TRP) family of cation channels is a large protein family, which is mainly structurally uniform. Proteins consist typically of six transmembrane domains and mostly four subunits are necessary to form a functional channel.
Rudi, Vennekens +2 more
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The Transient receptor potential (TRP) family of cation channels is a large protein family, which is mainly structurally uniform. Proteins consist typically of six transmembrane domains and mostly four subunits are necessary to form a functional channel.
Rudi, Vennekens +2 more
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Seminars in Immunopathology, 2015
Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cerebral cortex, where pain is finally
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Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cerebral cortex, where pain is finally
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Interaction of the trp repressor and RNA polymerase with the trp operon
Journal of Molecular Biology, 1975Abstract An in vitro transcription system for the tryptophan operon of Escherichia coli was used to determine the mechanism by which trp † repressor inhibits transcription of the operon. It was found that trp repressor-binding prevents binding of RNA polymerase to the operon. It was also observed that when polymerase is prebound to the trp promoter,
C L, Squires, F D, Lee, C, Yanofsky
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Interaction of the trp repressor with trp operator DNA fragments
European Biophysics Journal, 1993The interaction of the trp repressor with several trp operator DNA fragments has been examined by DNA gel retardation assays and by circular dichroism, in the absence and presence of the corepressor L-tryptophan. The holorepressor binds stoichiometrically to both the trpO and aroH operators, forming 1:1 complexes.
P, Beckmann, S R, Martin, A N, Lane
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