Results 261 to 270 of about 176,809 (302)
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2014
The Drosophila "transient receptor potential" channel is the prototypical TRP channel, belonging to and defining the TRPC subfamily. Together with a second TRPC channel, trp-like (TRPL), TRP mediates the transducer current in the fly's photoreceptors. TRP and TRPL are also implicated in olfaction and Malpighian tubule function.
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The Drosophila "transient receptor potential" channel is the prototypical TRP channel, belonging to and defining the TRPC subfamily. Together with a second TRPC channel, trp-like (TRPL), TRP mediates the transducer current in the fly's photoreceptors. TRP and TRPL are also implicated in olfaction and Malpighian tubule function.
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Direct recognition of the trp operator by the trp holorepressor — a review
Gene, 1994Two different X-ray co-crystal structures of the Escherichia coli trp holorepressor complexed with DNA suggest that the TrpR protein recognizes specific DNA sequences primarily with a network of water-mediated H-bonds. However, the more recent nuclear magnetic resonance (NMR) solution structures of the holorepressor-operator complex show no long-lived,
P, Youderian, D N, Arvidson
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2014
The mammalian olfactory system has become an excellent model system to understand the function of transient receptor potential (TRP) channels within their native cellular and circuit environment. The discovery that the canonical TRP channel TRPC2 is highly expressed in sensory neurons of the vomeronasal organ (VNO) has led to major advances in our ...
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The mammalian olfactory system has become an excellent model system to understand the function of transient receptor potential (TRP) channels within their native cellular and circuit environment. The discovery that the canonical TRP channel TRPC2 is highly expressed in sensory neurons of the vomeronasal organ (VNO) has led to major advances in our ...
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Current Pharmaceutical Design, 2009
Preclinical research has identified an array of ion channels in sensory neurons involved in the generation and transduction of pain as potential targets for pharmacological intervention. Paramount among these new targets is the family of thermosensitive transient receptor potential channels, referred to as "thermoTRPs".
Daniel N, Cortright, Arpad, Szallasi
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Preclinical research has identified an array of ion channels in sensory neurons involved in the generation and transduction of pain as potential targets for pharmacological intervention. Paramount among these new targets is the family of thermosensitive transient receptor potential channels, referred to as "thermoTRPs".
Daniel N, Cortright, Arpad, Szallasi
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Current Drug Target -CNS & Neurological Disorders, 2004
Noxious thermal, mechanical, or chemical stimuli evoke pain through excitation of the peripheral terminals called nociceptor, and many kinds of ionotropic and metabotropic receptors are involved in this process. Capsaicin receptor TRPV1 is a nociceptor-specific ion channel that serves as the molecular target of capsaicin.
Mitsuko, Numazaki, Makoto, Tominaga
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Noxious thermal, mechanical, or chemical stimuli evoke pain through excitation of the peripheral terminals called nociceptor, and many kinds of ionotropic and metabotropic receptors are involved in this process. Capsaicin receptor TRPV1 is a nociceptor-specific ion channel that serves as the molecular target of capsaicin.
Mitsuko, Numazaki, Makoto, Tominaga
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An Introduction on TRP Channels
Handbook of Experimental Pharmacology, 2007The transient receptor potential (TRP) ion channels are named after the role of the channels in Drosophila phototransduction. Mammalian TRP channel subunit proteins are encoded by at least 28 genes. TRP cation channels display an extraordinary assortment of selectivities and activation mechanisms, some of which represent previously unrecognized modes ...
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Comprehensive Physiology, 2012
Abstract TRP channels constitute a large superfamily of cation channel forming proteins, all related to the gene product of the transient receptor potential ( trp ) locus in Drosophila .
Maarten, Gees +3 more
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Abstract TRP channels constitute a large superfamily of cation channel forming proteins, all related to the gene product of the transient receptor potential ( trp ) locus in Drosophila .
Maarten, Gees +3 more
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Pflügers Archiv - European Journal of Physiology, 2005
The transient receptor potential (TRP) superfamily comprises a large group of related cation channels that display surprising diversity in the specific modes of activation and cation selectivities. However, a unifying theme is that many TRP channels play important roles in sensory physiology.
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The transient receptor potential (TRP) superfamily comprises a large group of related cation channels that display surprising diversity in the specific modes of activation and cation selectivities. However, a unifying theme is that many TRP channels play important roles in sensory physiology.
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2010
Microbes have made numerous contributions to the study of biology and medicine. Those contributions also include many original discovery's in the study of ion channels often thought as the province of neuroscientists or cardiophysiologists. Yeast have long been used as a model organism and TRP channel genes and their transmembrane products touted as ...
Marta, Kaleta, Christopher, Palmer
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Microbes have made numerous contributions to the study of biology and medicine. Those contributions also include many original discovery's in the study of ion channels often thought as the province of neuroscientists or cardiophysiologists. Yeast have long been used as a model organism and TRP channel genes and their transmembrane products touted as ...
Marta, Kaleta, Christopher, Palmer
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2017
The transient receptor potential (TRP) ion channels are named after the discovery of the photo-transducted channels in Drosophila. TRPs, activated by various extracellular and intracellular stimuli, play a plethora of physiological and pathological roles.
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The transient receptor potential (TRP) ion channels are named after the discovery of the photo-transducted channels in Drosophila. TRPs, activated by various extracellular and intracellular stimuli, play a plethora of physiological and pathological roles.
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