Results 271 to 280 of about 176,809 (302)

Trp Channels In Disease

2007
The transient receptor potential (TRP) channels are a large family of proteins with six main subfamilies termed the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and TRPA (ankyrin) groups. The sheer number of different TRPs with distinct functions supports the statement that these channels are involved in ...
S E, Jordt, B E, Ehrlich
openaire   +2 more sources

Advances in TRP Channel Drug Discovery: From Target Validation to Clinical Studies

Nature Reviews Drug Discovery, 2022
Árpád Szállási, Rachelle Gaudet, Ari Koivisto   +2 more
exaly  

TRP Channels and Thermosensation

2014
Several TRP channels exhibit highly temperature-dependent gating properties, which leads to steep changes in depolarising current upon either cooling or heating. Based on this characteristic feature, these so-called "thermoTRPs" have been widely studied with the aim to elucidate their potential key role as thermosensors in the somatosensory system and ...
openaire   +2 more sources

The Physiological Sensor Channels TRP and Piezo: Nobel Prize in Physiology or Medicine 2021

Physiological Reviews, 2022
Scott Earley, Luis F. Santana, William J Lederer   +2 more
exaly  

Thermosensation and TRP Channels

Somatosensory neurons can sense external temperature by converting sensation of temperature information to neural activity via afferent input to the central nervous system. Various populations of somatosensory neurons have specialized gene expression, including expression of thermosensitive transient receptor potential (TRP) ion channels ...
Makoto, Tominaga, Makiko, Kashio
openaire   +2 more sources

Sensory TRP Channels in Three Dimensions

Annual Review of Biochemistry, 2022
Melinda M Diver, John V Lin King, Yifan Cheng   +2 more
exaly  

The Regulatory and Modulatory Roles of TRP Family Channels in Malignant Tumors and Relevant Therapeutic Strategies

Acta Pharmaceutica Sinica B, 2022
Tiecheng Zhong, Qiaojun He, Ling Ding
exaly  

TRPs revisited

Acta Physiologica, 2015
openaire   +2 more sources

Structural Pharmacology of TRP Channels

Journal of Molecular Biology, 2021
Vera Moiseenkova-Bell
exaly  

Rose Bengal-Sensitized Photooxidation of the Dipeptides Trp-Phe, Trp-Tyr and Trp-Trp. Kinetics, Mechanism and Photoproducts

Photochemistry and Photobiology, 2004
Ariana Posadaz, Alicia Biasutti, César Casale, Jesús Sanz, Francisco Amat-Guerri, Norman A. Garcia   +5 more
openaire   +1 more source