Results 1 to 10 of about 14,118 (233)

Chronic alcohol consumption downregulates TRPA1 ion channel and the main peptidergic messengers of the Edinger-Westphal nucleus [PDF]

Scientific Reports
The urocortin 1 (UCN1) and cocaine- and amphetamine-regulated transcript (CART) co-expressing neurons of the centrally projecting Edinger-Westphal nucleus (EWcp), regulate the function of reward- and addiction-related brain areas.
Ammar Al-Omari, Izabella Török, Balázs Zoltán Zsidó, Csaba Hetényi, Erika Pintér, Zoltán Sándor, Gergely Berta, Péter Szocsics, Péter Gombás, Tünde Biró-Sütő, Balázs Gaszner, Viktória Kormos   +11 more
doaj   +2 more sources

Schwann cell Lrp1 deletion drives trigeminal neuron sensitization and orofacial pain by modulating mitochondrial function and TRPV1/TRPA1 activity. [PDF]

J Headache Pain
Gong Z, Zhang M, Liu N, Asam K, Martellucci S, Aouizerat B, Campana W, Ye Y.   +7 more
europepmc   +2 more sources

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

Nature, 2007
Lindsey J Macpherson, Ardem Patapoutian
exaly   +2 more sources

Identification of Ligands for Chicken Transient Receptor Potential Ankyrin 1 Channel and Chemosensory Perception of Herbal Compounds in Chickens

The Journal of Poultry Science, 2022
The pungency induced by spices and herbs plays an important role in food choice and appetite, and it is suggested that adding spices and herbs to feed as natural alternatives to antibiotics has beneficial effects in poultry farming.
Fuminori Kawabata, Kana Murayama, Yuta Yoshida, Ruojun Liang, Shotaro Nishimura, Shoji Tabata   +5 more
doaj   +1 more source

Proof of Pharmacology, Safety, and Pharmacokinetics of the Novel TRPA1 Antagonist BI 1839100: A Randomized, Placebo-Controlled, Parallel Group, First-In-Human Study in Healthy Male Participants. [PDF]

Clin Transl Sci
van Ruissen MCE, van Kraaij SJW, Wolfova J, Herrmann FE, Botilde Y, Wollin L, Klarenbeek NB.   +6 more
europepmc   +2 more sources

Methylglyoxal evokes pain by stimulating TRPA1. [PDF]

PLoS ONE, 2013
Diabetic neuropathy is a severe complication of long-standing diabetes and one of the major etiologies of neuropathic pain. Diabetes is associated with an increased formation of reactive oxygen species and the electrophilic dicarbonyl compound ...
David A Andersson, Clive Gentry, Emily Light, Nisha Vastani, Julie Vallortigara, Angelika Bierhaus, Thomas Fleming, Stuart Bevan   +7 more
doaj   +1 more source

TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex

Scientific Reports, 2023
Transient receptor potential ankyrin 1 (TRPA1) is a member of the TRP channel family and is expressed in peripheral and central nervous systems. In the periphery, TRPA1 senses cold and pain. However, the functions of TRPA1 in the CNS are unclear.
Ryo Kawabata, Shuji Shimoyama, Shinya Ueno, Ikuko Yao, Akiko Arata, Kohei Koga   +5 more
doaj   +1 more source

Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. [PDF]

PLoS ONE, 2012
BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism.
Romina Nassini, Pamela Pedretti, Nadia Moretto, Camilla Fusi, Chiara Carnini, Fabrizio Facchinetti, Arturo Roberto Viscomi, Anna Rita Pisano, Susan Stokesberry, Charlott Brunmark, Naila Svitacheva, Lorcan McGarvey, Riccardo Patacchini, Anders B Damholt, Pierangelo Geppetti, Serena Materazzi   +15 more
doaj   +1 more source

An Immunometabolic Shift Modulates Cytotoxic Lymphocyte Activation During Melanoma Progression in TRPA1 Channel Null Mice

Frontiers in Oncology, 2021
Melanoma skin cancer is extremely aggressive with increasing incidence and mortality. Among the emerging therapeutic targets in the treatment of cancer, the family of transient receptor potential channels (TRPs) has been reported as a possible ...
Maria Fernanda Forni, Omar Alberto Domínguez-Amorocho, Leonardo Vinícius Monteiro de Assis, Gabriela Sarti Kinker, Maria Nathalia Moraes, Ana Maria de Lauro Castrucci, Ana Maria de Lauro Castrucci, Niels Olsen Saraiva Câmara   +7 more
doaj   +1 more source

Effect of dose of thymol and supplemental flavours or camphor on palatability in a choice feedings study with piglets

Czech Journal of Animal Science, 2012
Thymol's antimicrobial properties urged researchers to study its effect on animal performance and intestinal health in pigs. However, thymol has the characteristic sharp odor of thyme and a bitter, aromatic, and sometimes burning sensation which may ...
J. Michiels, J. Missotten, A. Ovyn, N. Dierick, D. Fremaut, S. De Smet   +5 more
doaj   +1 more source