Results 1 to 10 of about 11,892 (197)
Nanoparticles-Mediated Modulation of TRP Channels: Advances and Therapeutic Potential. [PDF]
Wiley Interdiscip Rev Nanomed NanobiotechnolNanoparticle‐mediated modulation of TRP channels, highlighting the interplay between external stimuli, tailored nanomaterials, and TRP channel activation across a range of physiological contexts. This review examines the roles of TRP channels in cellular signaling and disease, providing insights into how advances in nanotechnology can facilitate ...
Foster KA +3 more
europepmc +2 more sources
TRPA1 Expressed by Hepatocytes and Liver Macrophages Does Not Mediate Inflammatory Infiltration and Steatosis in a Mouse Model of Chronic Alcohol-Induced Liver Injury [PDF]
CellsTransient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel, and its activator, the alcohol breakdown product acetaldehyde, plays a key role in the pathomechanism of alcoholic liver disease (ALD).
Dorottya Luca Fehér +7 more
doaj +2 more sources
Chronic alcohol consumption downregulates TRPA1 ion channel and the main peptidergic messengers of the Edinger-Westphal nucleus [PDF]
Scientific ReportsThe urocortin 1 (UCN1) and cocaine- and amphetamine-regulated transcript (CART) co-expressing neurons of the centrally projecting Edinger-Westphal nucleus (EWcp), regulate the function of reward- and addiction-related brain areas.
Ammar Al-Omari +11 more
doaj +2 more sources
The Journal of Poultry Science, 2022 The pungency induced by spices and herbs plays an important role in food choice and appetite, and it is suggested that adding spices and herbs to feed as natural alternatives to antibiotics has beneficial effects in poultry farming.
Fuminori Kawabata +5 more
doaj +1 more source
Methylglyoxal evokes pain by stimulating TRPA1. [PDF]
PLoS ONE, 2013 Diabetic neuropathy is a severe complication of long-standing diabetes and one of the major etiologies of neuropathic pain. Diabetes is associated with an increased formation of reactive oxygen species and the electrophilic dicarbonyl compound ...
David A Andersson +7 more
doaj +1 more source
TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex
Scientific Reports, 2023 Transient receptor potential ankyrin 1 (TRPA1) is a member of the TRP channel family and is expressed in peripheral and central nervous systems. In the periphery, TRPA1 senses cold and pain. However, the functions of TRPA1 in the CNS are unclear.
Ryo Kawabata +5 more
doaj +1 more source
Czech Journal of Animal Science, 2012 Thymol's antimicrobial properties urged researchers to study its effect on animal performance and intestinal health in pigs. However, thymol has the characteristic sharp odor of thyme and a bitter, aromatic, and sometimes burning sensation which may ...
J. Michiels +5 more
doaj +1 more source
Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. [PDF]
PLoS ONE, 2012 BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism.
Romina Nassini +15 more
doaj +1 more source
Frontiers in Oncology, 2021 Melanoma skin cancer is extremely aggressive with increasing incidence and mortality. Among the emerging therapeutic targets in the treatment of cancer, the family of transient receptor potential channels (TRPs) has been reported as a possible ...
Maria Fernanda Forni +7 more
doaj +1 more source
Application of PASS Algorithm for the Discovery of New Trpa1 Antagonists
Proceedings, 2019 TRPA1 is a calcium ion channel found on the plasma membrane of many animal cells and it is [...]
Trif Comin +4 more
doaj +1 more source