Results 21 to 30 of about 14,118 (233)
Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity [PDF]
Nature Communications, 2013 Transient receptor potential ankyrin 1 (TRPA1) protein is a nonselective cation channel. Although many studies suggest that TRPA1 is involved in inflammatory and neuropathic pain, its mechanism remains unclear. Here we identify an alternative splice variant of the mouse Trpa1 gene.
Zhou, Yiming +3 more
openaire +4 more sources
Application of PASS Algorithm for the Discovery of New Trpa1 Antagonists
Proceedings, 2019 TRPA1 is a calcium ion channel found on the plasma membrane of many animal cells and it is [...]
Trif Comin +4 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Transient receptor potential ankyrin 1 (TRPA1) channel is an ion channel whose gating is controlled by agonists, such as allyl isothiocyanate (AITC), and temperature.
Megumi Yoshida +4 more
doaj +1 more source
Pharmaceuticals, 2021 Oligodendrocytes produce myelin, which provides insulation to axons and speeds up neuronal transmission. In ischaemic conditions, myelin is damaged, resulting in mental and physical disabilities.
Wendy Lajoso +7 more
doaj +1 more source
Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke
eLife, 2018 Hypoxia and ischemia are linked to oxidative stress, which can activate the oxidant-sensitive transient receptor potential ankyrin 1 (TRPA1) channel in cerebral artery endothelial cells, leading to vasodilation.
Paulo Wagner Pires, Scott Earley
doaj +1 more source
TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide. [PDF]
PLoS ONE, 2012 Hydrogen sulfide (H(2)S), which is produced endogenously from L-cysteine, is an irritant with pro-nociceptive actions. We have used measurements of intracellular calcium concentration, electrophysiology and behavioral measurements to show that the ...
David A Andersson +2 more
doaj +1 more source
TRPA1: A Gatekeeper for Inflammation [PDF]
Annual Review of Physiology, 2013 Tissue damage evokes an inflammatory response that promotes the removal of harmful stimuli, tissue repair, and protective behaviors to prevent further damage and encourage healing. However, inflammation may outlive its usefulness and become chronic. Chronic inflammation can lead to a host of diseases, including asthma, itch, rheumatoid arthritis, and ...
Diana M, Bautista +2 more
openaire +2 more sources
Function and therapeutic potential of transient receptor potential ankyrin 1 in fibrosis
Frontiers in Pharmacology, 2022 The transient receptor potential (TRP) protein superfamily is a special group of cation channels expressed in different cell types and signaling pathways.
Yicheng Wei +10 more
doaj +1 more source
Ultrasonic Neuromodulation via Astrocytic TRPA1 [PDF]
Current Biology, 2019 Low-intensity, low-frequency ultrasound (LILFU) is the next-generation, non-invasive brain stimulation technology for treating various neurological and psychiatric disorders. However, the underlying cellular and molecular mechanism of LILFU-induced neuromodulation has remained unknown.
Soo-Jin, Oh +17 more
openaire +3 more sources
Neural Regeneration Research, 2019 Transient receptor potential ankyrin 1 (TRPA1) is a key player in pain and neurogenic inflammation, and is localized in nociceptive primary sensory dorsal root ganglion (DRG) neurons.
Xiao-Lei Wang +7 more
doaj +1 more source