Results 31 to 40 of about 11,892 (197)
BMC Research Notes, 2021 Objective Transient receptor potential ankyrin 1 (TRPA1) is an excitatory ion channel expressed on a subset of sensory neurons. TRPA1 is activated by a host of noxious stimuli including pollutants, irritants, oxidative stress and inflammation, and is ...
Parmvir K. Bahia, Thomas E. Taylor-Clark
doaj +1 more source
ROS/TRPA1/CGRP signaling mediates cortical spreading depression
The Journal of Headache and Pain, 2019 Objectives The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-related peptide (CGRP) are targets for migraine prophylaxis.
Liwen Jiang +3 more
doaj +1 more source
TRPA1 Contributes to Cold Hypersensitivity [PDF]
The Journal of Neuroscience, 2010 TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely accepted that TRPA1 serves as a broad irritancy receptor for a variety of reactive chemicals, its role in cold sensation remains controversial. Here, we demonstrate that mild cooling markedly increases agonist-evoked rat TRPA1 currents.
Donato, del Camino +17 more
openaire +2 more sources
Molecular Pain, 2007 Agonists of TRPA1 such as mustard oil and its key component AITC cause pain and neurogenic inflammation in humans and pain behavior in rodents. TRPA1 is activated by numerous reactive compounds making it a sensor for reactive compounds in the body ...
Immke David C +6 more
doaj +1 more source
TRPA1‐mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1 [PDF]
European Journal of Neuroscience, 2009 AbstractThe transient receptor potential (TRP)A1 channel is involved in the transduction of inflammation‐induced noxious stimuli from the periphery. Previous studies have characterized the properties of TRPA1 in heterologous expression systems. However, there is little information on the properties of TRPA1‐mediated currents in sensory neurons.
Margaux M, Salas +2 more
openaire +2 more sources
TRPA1 mediates formalin-induced pain [PDF]
Proceedings of the National Academy of Sciences, 2007 The formalin model is widely used for evaluating the effects of analgesic compounds in laboratory animals. Injection of formalin into the hind paw induces a biphasic pain response; the first phase is thought to result from direct activation of primary afferent sensory neurons, whereas the second phase has been proposed to reflect the ...
Colleen R, McNamara +10 more
openaire +2 more sources
TRPA1 expression and its functional activation in rodent cortex [PDF]
Open Biology, 2017 TRPA1 is a non-selective cation channel involved in pain sensation and neurogenic inflammation. Although TRPA1 is well established in a number of organs including the nervous system, its presence and function in the mammalian cortex remains unclear. Here,
Ehsan Kheradpezhouh +3 more
doaj +1 more source
TRPA1: Acrolein meets its target [PDF]
Toxicology and Applied Pharmacology, 2017 Two papers in this issue of Toxicology and Applied Pharmacology reveal that the sensory irritant receptor, Transient Receptor Potential Ankyrin 1 (TRPA1), plays a key role in the morbidity and mortality caused by inhalation of acrolein, the major electrophile in smoke from fires, tobacco and in automobile exhaust (Conklin et al., 2016; Kurhanewicz et ...
Satyanarayana Achanta, Sven-Eric Jordt
openaire +2 more sources
Cells, 2018 The chemosensory transient receptor potential ankyrin 1 (TRPA1) ion channel perceives different sensory stimuli. It also interacts with reactive exogenous compounds including the chemical warfare agent sulfur mustard (SM).
Robin Lüling +6 more
doaj +1 more source
Pharmaceuticals, 2021 Transient receptor potential ankyrin 1 (TRPA1), a nonselective cation channel, contributes to several (patho)physiological processes. Smell loss is an early sign in several neurodegenerative disorders, such as multiple sclerosis, Parkinson’s and ...
János Konkoly +9 more
doaj +1 more source