Results 41 to 50 of about 11,892 (197)
Research Results in PharmacologyIntroduction: Oxaliplatin is a platinum-based chemotherapy agent that often causes chemotherapy-induced peripheral neuropathy (CIPN). This effect limits the potential activity and decreases the cancer patient’s quality of life. Melanocortin and transient
Alma Nuril Aliya +11 more
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Annexin A2 Regulates TRPA1-Dependent Nociception [PDF]
The Journal of Neuroscience, 2014 The transient receptor potential A1 (TRPA1) channel is essential for vertebrate pain. Even though TRPA1 activation by ligands has been studied extensively, the molecular machinery regulating TRPA1 is only poorly understood. Using an unbiased proteomics-based approach we uncovered the physical association of Annexin A2 (AnxA2) with native TRPA1 in mouse
Luca Avenali +6 more
openaire +5 more sources
TRPA1 as Target in Myocardial Infarction
International Journal of Molecular Sciences, 2023 Transient receptor potential cation channel subfamily A member 1 (TRPA1), an ion channel primarily expressed on sensory neurons, can be activated by substances occurring during myocardial infarction. Aims were to investigate whether activation, inhibition, or absence of TRPA1 affects infarcts and to explore underlying mechanisms.
Clara Hoebart +6 more
openaire +2 more sources
Chilling injury mechanism in the immature oocytes of zebrafish (Danio rerio)
The Journal of Reproduction and DevelopmentImmature zebrafish oocytes are sensitive to chilling, and their survival is markedly reduced by exposure to 0°C. In the present study, we investigated the involvement of cold-sensitive channels and lipid mediators in chilling injury in immature zebrafish ...
Yanuar ACHADRI +4 more
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Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation [PDF]
Royal Society Open Science, 2015 We show that the physiological activity of solid aerosolized benzylidenemalononitriles (BMNs) including ‘tear gas’ (CS) in historic human volunteer trials correlates with activation of the human transient receptor potential ankyrin 1 ion channel (hTRPA1).
Christopher D. Lindsay +8 more
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Medicine Bulletin, EarlyView.ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang +5 more
wiley +1 more source
TMEM100, a regulator of TRPV1-TRPA1 interaction, contributes to temporomandibular disorder pain
Frontiers in Molecular Neuroscience, 2023 There is an unmet need to identify new therapeutic targets for temporomandibular disorder (TMD) pain because current treatments are limited and unsatisfactory.
Peng Wang +7 more
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Environmental Toxicology, EarlyView.ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye +5 more
wiley +1 more source
Linkage of alternative exon assembly in Drosophila TrpA1 transcripts
Molecules and Cells: Drosophila TrpA1 (transient receptor potential ankyrin 1) transcripts are alternatively spliced at 2 distinct sites each with a choice of mutually exclusive exons.
Eun Jo Du +5 more
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Cells, 2020 Insulin secretion from the β-cells of the islets of Langerhans is triggered mainly by nutrients such as glucose, and incretin hormones such as glucagon-like peptide-1 (GLP-1).
Md. Shahidul Islam
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