Results 41 to 50 of about 14,118 (233)

Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 (HSPA6) In Vitro

Cells, 2018
The chemosensory transient receptor potential ankyrin 1 (TRPA1) ion channel perceives different sensory stimuli. It also interacts with reactive exogenous compounds including the chemical warfare agent sulfur mustard (SM).
Robin Lüling, Harald John, Thomas Gudermann, Horst Thiermann, Harald Mückter, Tanja Popp, Dirk Steinritz   +6 more
doaj   +1 more source

Chilling injury mechanism in the immature oocytes of zebrafish (Danio rerio)

The Journal of Reproduction and Development
Immature zebrafish oocytes are sensitive to chilling, and their survival is markedly reduced by exposure to 0°C. In the present study, we investigated the involvement of cold-sensitive channels and lipid mediators in chilling injury in immature zebrafish ...
Yanuar ACHADRI, Shino SONODA, Saki OKUBO, Kazutsugu MATSUKAWA, Keisuke EDASHIGE   +4 more
doaj   +1 more source

TRPA1 expression and its functional activation in rodent cortex [PDF]

Open Biology, 2017
TRPA1 is a non-selective cation channel involved in pain sensation and neurogenic inflammation. Although TRPA1 is well established in a number of organs including the nervous system, its presence and function in the mammalian cortex remains unclear. Here,
Ehsan Kheradpezhouh, Julian M. C. Choy, Vincent R. Daria, Ehsan Arabzadeh   +3 more
doaj   +1 more source

TMEM100, a regulator of TRPV1-TRPA1 interaction, contributes to temporomandibular disorder pain

Frontiers in Molecular Neuroscience, 2023
There is an unmet need to identify new therapeutic targets for temporomandibular disorder (TMD) pain because current treatments are limited and unsatisfactory.
Peng Wang, Qiaojuan Zhang, Fabiana C. Dias, Abbie Suttle, Xinzhong Dong, Yong Chen, Yong Chen, Yong Chen   +7 more
doaj   +1 more source

Annexin A2 Regulates TRPA1-Dependent Nociception [PDF]

The Journal of Neuroscience, 2014
The transient receptor potential A1 (TRPA1) channel is essential for vertebrate pain. Even though TRPA1 activation by ligands has been studied extensively, the molecular machinery regulating TRPA1 is only poorly understood. Using an unbiased proteomics-based approach we uncovered the physical association of Annexin A2 (AnxA2) with native TRPA1 in mouse
Luca Avenali, Pratibha Narayanan, Tom Rouwette, Ilaria Cervellini, Michael Sereda, David Gomez-Varela, Manuela Schmidt   +6 more
openaire   +5 more sources

TRPA1 as Target in Myocardial Infarction

International Journal of Molecular Sciences, 2023
Transient receptor potential cation channel subfamily A member 1 (TRPA1), an ion channel primarily expressed on sensory neurons, can be activated by substances occurring during myocardial infarction. Aims were to investigate whether activation, inhibition, or absence of TRPA1 affects infarcts and to explore underlying mechanisms.
Clara Hoebart, Attila Kiss, Patrick M. Pilz, Petra L. Szabo, Bruno K. Podesser, Michael J. M. Fischer, Stefan Heber   +6 more
openaire   +2 more sources

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Effect of Functional Nasal Surgery on Craniofacial Pain: A Prospective Cohort Study

The Laryngoscope, EarlyView.
About 40% of patients presenting for nasal obstruction had craniofacial pain (CPF) preoperatively. In patients with nasal obstruction and CFP preoperatively, functional nasal surgery led to significant improvements in both nasal obstruction and CFP, and these improvements persisted at about 6 months postoperatively. ABSTRACT Objectives Functional nasal
John R. Craig, Jeewanjot S. Grewal, Anne Grossbauer, Carl Wilson, Robert H. Deeb   +4 more
wiley   +1 more source

Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation [PDF]

Royal Society Open Science, 2015
We show that the physiological activity of solid aerosolized benzylidenemalononitriles (BMNs) including ‘tear gas’ (CS) in historic human volunteer trials correlates with activation of the human transient receptor potential ankyrin 1 ion channel (hTRPA1).
Christopher D. Lindsay, Christopher Green, Mike Bird, James T. A. Jones, James R. Riches, Katherine K. McKee, Mark S. Sandford, Debra A. Wakefield, Christopher M. Timperley   +8 more
doaj   +1 more source

The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Environmental pollution and climate change seriously affect human health, leading to the onset and exacerbation of chronic respiratory diseases, such as allergic rhinitis and lung diseases. Over the past several decades, increasing air pollution and environmental exposure owing to global urbanization, industrialization, and rapid economic ...
Xin‐Yan Liu, Rui‐Ming Han, Yong‐Tai Wang, Dong‐Dong Zhu, Cui‐Da Meng   +4 more
wiley   +1 more source