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Agonist-Induced Changes in Ca2+ Permeation through the Nociceptor Cation Channel TRPA1 [PDF]

Biophysical Journal, 2010
The Ca(2+)-permeable cation channel TRPA1 acts as an ionotropic receptor for various pungent compounds and as a noxious cold sensor in sensory neurons. It is unclear what proportion of the TRPA1-mediated current is carried by Ca(2+) ions and how the permeation pathway changes during stimulation.
Thomas Voets, Karel Talavera, Bernd Nilius   +2 more
exaly   +3 more sources

Nicotine activates the chemosensory cation channel TRPA1 [PDF]

Nature Neuroscience, 2009
Topical application of nicotine, as used in nicotine replacement therapies, causes irritation of the mucosa and skin. This reaction has been attributed to activation of nicotinic acetylcholine receptors (nAChRs) in chemosensory neurons. In contrast with this view, we found that the chemosensory cation channel transient receptor potential A1 (TRPA1) is ...
Jeroen Vanoirbeek, Thomas Voets, Rudi Vennekens   +2 more
exaly   +5 more sources

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Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cells

Biochemical Pharmacology, 2013
TRPA1, a member of the transient receptor potential (TRP) family of cation channels, has mainly been characterized as a chemosensory protein in neuronal cells. TRPA1 is activated by toxic or irritating volatile agents like allyl isothiocyanate (AITC), tear gas, formalin, or cigarette smoke.
Thomas Gudermann, Achim Aigner
exaly   +3 more sources

Lacking TRPA1 Cation Channel Impairs Primary Closure of a Stromal Incision Injury in a Mouse Cornea

Laboratory Investigation
The cornea is a highly sensory, innervated, avascular tissue that consists of epithelium, keratocytes, endothelium, and an extracellular matrix. We evaluated the effects of gene knockout (KO) of the TRPA1, a membrane cation channel potentially activated by various external stimuli, on the wound-healing process in corneal stroma following an incision ...
Takayoshi Sumioka, Peter Reinach, Shingo Yasuda   +2 more
exaly   +3 more sources

Expression and distribution of the transient receptor potential cationic channel ankyrin 1 (TRPA1) in the human vagina

International Journal of Impotence Research, 2014
The transient receptor potential cationic channel type A1 (TRPA1), belonging to a superfamily of cationic membrane channels, has been suggested to act as mechano- and pain sensor and, thus, to play a role in neurotransmission in the human body, including the urogenital tract.
S, Ückert, J E, Sonnenberg, K, Albrecht, M A, Kuczyk, P, Hedlund   +4 more
openaire   +2 more sources

A role for transient receptor potential ankyrin 1 cation channel (TRPA1) in airway hyper-responsiveness?

Canadian Journal of Physiology and Pharmacology, 2015
Airway smooth muscle (ASM) contraction controls the airway caliber. Airway narrowing is exaggerated in obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD). The mechanism by which ASM tone is dysregulated in disease is not clearly understood.
Aruni, Jha, Pawan, Sharma, Vidyanand, Anaparti, Min H, Ryu, Andrew J, Halayko   +4 more
openaire   +2 more sources

Expression and distribution of the transient receptor potential cationic channel A1 (TRPA1) in the human clitoris—comparison to male penile erectile tissue

International Journal of Impotence Research, 2017
The transient receptor potential cationic channel ankyrin 1 (TRPA1) is a channel protein assumed to act in various human tissues as mechano- and pain sensor and play a role in neurotransmission. The expression of TRPA has already been investigated in the human prostate and urethra, however, only very few studies have addressed the expression and ...
S, Ückert, K, Albrecht, A, Bannowsky, M, Sohn, M A, Kuczyk, P, Hedlund   +5 more
openaire   +2 more sources

Borneol inhibits TRPA1, a proinflammatory and noxious pain-sensing cation channel.

Pakistan journal of pharmaceutical sciences, 2016
Borneol, a natural product isolated from several species of Artemisia, Blumea and Kaempferia, has a widespread use in traditional medicine. TRP ion channels are a class of nonselective cation channel proteins involved in a variety of physiological and pathological processes in mammals.
Muhammad Azhar, Sherkheli, Benjamin, Schreiner, Rizwanul, Haq, Markus, Werner, Hanns, Hatt   +4 more
openaire   +1 more source

Mechanisms Regulating Transient Receptor Potential Cation Channel A1 (TRPA1) and Their Roles in Nociception and Nociceptive Sensitization

2020
Nociception is the sensory nervous system that detects harmful stimuli including excessive heat, cold, toxic chemicals, and noxious mechanical stimulations. Transient receptor potential (TRP) channels are a group of evolutionarily conserved ion channels consisting of 4 subunits, each with 6 transmembrane spans, and detect a variety of external and ...
openaire   +2 more sources

Expression des Transient Receptor Potential Cationic Channel A1 (TRPA1) im humanen Corpus cavernosum penis und den Vesicula seminalis – Eine immunhistochemische Studie

2015
Fragestellung: Die Ergebnisse basiswissenschaftlicher Arbeiten geben Hinweise darauf, dass das Kanalprotein Transient Receptor Potential Cationic Channel A1 (TRPA1) am Mechanismus der mechano-afferenten/efferenten Signalübertragung in der Harnblase, Prostata und Urethra beteiligt ist. Die [for full text, please go to the a.m. URL]
Ückert, S, Bannowsky, A, Kuczyk, MA, Hedlund, P   +3 more
openaire   +2 more sources