Results 21 to 30 of about 1,267,413 (183)
Slack Potassium Channels Modulate TRPA1-Mediated Nociception in Sensory Neurons
Cells, 2022 The transient receptor potential (TRP) ankyrin type 1 (TRPA1) channel is highly expressed in a subset of sensory neurons where it acts as an essential detector of painful stimuli.
Fangyuan Zhou +8 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Transient receptor potential ankyrin 1 (TRPA1) channel is an ion channel whose gating is controlled by agonists, such as allyl isothiocyanate (AITC), and temperature.
Megumi Yoshida +4 more
doaj +1 more source
Scientific Reports, 2022 Extracellular ATP (adenosine triphosphate) and transient receptor potential ankyrin 1 (TRPA1) channels are involved in calcium signaling in odontoblasts and dental pain.
Ai Orimoto, Chiaki Kitamura, Kentaro Ono
doaj +1 more source
Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D-Serine Signaling. [PDF]
Adv Sci (Weinh)Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Han K +11 more
europepmc +2 more sources
TRPA1 Channels Modify TRPV1-Mediated Current Responses in Dorsal Root Ganglion Neurons
Frontiers in Physiology, 2017 The transient receptor potential vanilloid 1 (TRPV1) channel is highly expressed in a subset of sensory neurons in the dorsal root ganglia (DRG) and trigeminal ganglia of experimental animals, responsible for nociception.
Takayoshi Masuoka +7 more
doaj +1 more source
Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension
Frontiers in Molecular Biosciences, 2023 Introduction: Hypoxia-induced dilation of cerebral arteries orchestrated by Ca2+-permeable transient receptor potential ankyrin 1 (TRPA1) cation channels on endothelial cells is neuroprotective during ischemic stroke, but it is unknown if the channel has
Michelle N. Sullivan +7 more
doaj +1 more source
Functional evidence of distinct electrophile-induced activation states of the ion channel TRPA1
Biochemistry and Biophysics Reports, 2021 Transient Receptor Potential Ankyrin 1 (TRPA1) is a tetrameric, nonselective cation channel expressed on nociceptive sensory nerves whose activation elicits nocifensive responses (e.g. pain).
Thomas A. Parks +2 more
doaj +1 more source
Bimodal action of menthol on the transient receptor potential channel TRPA1 [PDF]
, 2007 TRPA1 is a calcium-permeable nonselective cation transient receptor potential (TRP) channel that functions as an excitatory ionotropic receptor in nociceptive neurons. TRPA1 is robustly activated by pungent substances in mustard oil, cinnamon, and garlic
Damann, Nils +6 more
core +1 more source
Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol
eLife, 2019 The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation.
Justyna B Startek +9 more
doaj +1 more source
Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel
, 2020 The role of mammalian Transient Receptor Potential Ankyrin 1 (TRPA1) as a mechanosensor is controversial. Here, we report that purified human TRPA1 (hTRPA1) with and without its N-terminal ankyrin repeat domain responded with pressure-dependent single ...
Zygmunt, Peter M. +6 more
core +1 more source