Results 31 to 40 of about 1,267,413 (183)

The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives

, 2015
Background and purpose Although still used by hundreds of millions of people worldwide, the mechanism of the analgesic action of the pyrazolone derivatives (PDs), dipyrone, propyphenazone and antipyrine, remains unknown. The transient receptor potential
Benemei S., Chiarugi A, Coppi E, Marone IM, Tonello R, Fusi C, Nassini R, TUCCINARDI, TIZIANO, Materazzi S, Preti D, Geppetti P, Patacchini R, De Logu F   +12 more
core   +2 more sources

Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. [PDF]

PLoS ONE, 2012
BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism.
Romina Nassini, Pamela Pedretti, Nadia Moretto, Camilla Fusi, Chiara Carnini, Fabrizio Facchinetti, Arturo Roberto Viscomi, Anna Rita Pisano, Susan Stokesberry, Charlott Brunmark, Naila Svitacheva, Lorcan McGarvey, Riccardo Patacchini, Anders B Damholt, Pierangelo Geppetti, Serena Materazzi   +15 more
doaj   +1 more source

Non-Analgesic Symptomatic or Disease—Modifying Potential of TRPA1

Medical Sciences, 2019
TRPA1, a versatile ion channel of the Transient Receptor Potential (TRP) channel family, detects a large variety of chemicals and can contribute to signal processing of other stimuli, e.g., due to its sensitivity to cytosolic calcium elevation or ...
Stefan Heber, Michael J.M. Fischer
doaj   +1 more source

Prerequisite Binding Modes Determine the Dynamics of Action of Covalent Agonists of Ion Channel TRPA1

Pharmaceuticals, 2021
Transient receptor potential ankyrin 1 (TRPA1) is a transmembrane protein channeling the influx of calcium ions. As a polymodal nocisensor, TRPA1 can be activated by thermal, mechanical stimuli and a wide range of chemically damaging molecules including ...
Balázs Zoltán Zsidó, Rita Börzsei, Erika Pintér, Csaba Hetényi   +3 more
doaj   +1 more source

Tumor Necrosis Factor-α Regulates the TRPA1 Expression in Human Odontoblast-Like Cells

Journal of Pain Research, 2020
Jie Liu,1,* Kehua Que,1,* Yangqiu Liu,1 Chengcheng Zang,1 Jing Wen1,2 1Department of Endodontics, College of Stomatology, Tianjin Medical University, Tianjin, People’s Republic of China; 2Lotus Dental Clinic, Guangzhou, Guangdong Province, People ...
Liu J, Que K, Liu Y, Zang C, Wen J
doaj  

Transient receptor potential ankyrin 1 (TRPA1) mediates reactive oxygen species-induced Ca2+ entry, mitochondrial dysfunction, and caspase-3/7 activation in primary cultures of metastatic colorectal carcinoma cells

Cell Death Discovery, 2023
Colorectal carcinoma (CRC) represents the fourth most common cancer worldwide and is the third most common cause of malignancy-associated mortality. Distant metastases to the liver and lungs are the main drivers of CRC-dependent death.
Pawan Faris, Agnese Rumolo, Giorgia Pellavio, Matteo Tanzi, Mauro Vismara, Roberto Berra-Romani, Andrea Gerbino, Salvatore Corallo, Paolo Pedrazzoli, Umberto Laforenza, Daniela Montagna, Francesco Moccia   +11 more
doaj   +1 more source

TRPA1 channel mediates organophosphate-induced delayed neuropathy

, 2017
The organophosphate-induced delayed neuropathy (OPIDN), often leads to paresthesias, ataxia and paralysis, occurs in the late-stage of acute poisoning or after repeated exposures to organophosphate (OP) insecticides or nerve agents, and may contribute to
Jian Li, Sui Fang, Bernard Attali, Qiang Ding, Youxin Wang, Xueqin Chen, Fuyun Tian, Xiang Xu, Xin Xie, Zhaobing Gao   +9 more
core   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli

Advanced Science, EarlyView.
An innervated human skin equivalent is integrated with high‐density microelectrode arrays to reveal how engineered free nerve ending–like structures translate touch and temperature into electrical codes. Mechanical indentation and thermal stimulation engage the engineered somatosensory circuitry and evoke distinct firing and waveform signatures ...
Daniele Bellantoni, Costantino Casale, Marika Sperduti, Nevio L. Tagliamonte, Giorgia Imparato, Loredana Zollo, Paolo A. Netti   +6 more
wiley   +1 more source

Envolvimento do receptor de potencial transitório A1 (TRPA1) na manutenção da hiperalgesia mecânica e térmica (Frio) na inflamação persistente [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2010O presente estudo investiga o papel do receptor TRPA1 no esenvolvimento e manutenção da ...
Costa, Diogo Santos Martins da
core