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TRPM2 functions as Ca2+ release channel in beta-cells
TRPM2 functions as Ca2+ release channel in beta-cellsopenaire +1 more source
Structural and functional characterization of Nudix motif in TRPM2 channel
Structural and functional characterization of Nudix motif in TRPM2 channelopenaire +1 more source
A critical role of TRPM2 channel in inflammatory and neuropathic pain
A critical role of TRPM2 channel in inflammatory and neuropathic painopenaire +1 more source
Curcumin Inhibits Activation of TRPM2 Channels in Rat Hepatocytes
Redox Biology, 2016 Oxidative stress is a hallmark of many liver diseases including viral and drug-induced hepatitis, ischemia-reperfusion injury, and non-alcoholic steatohepatitis. One of the consequences of oxidative stress in the liver is deregulation of Ca(2+) homeostasis, resulting in a sustained elevation of the free cytosolic Ca(2+) concentration ([Ca(2+)]c) in ...
Grigori Y Rychkov, Ehsan Kheradpezhouh
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Lys1110 of TRPM2 is critical for channel activation
Biochemical Journal, 2013TRPM2 (transient receptor potential melastatin 2) is a non-selective Ca2+-permeable cation channel activated by ADPR (adenosine diphosphoribose) and H2O2. It is widely expressed in mammalian cells and plays an important role in the regulation of various cell functions.
Taek-Keun, Kim +11 more
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Flufenamic acid is a pH-dependent antagonist of TRPM2 channels
Neuropharmacology, 2004Like a number of other TRP channels, TRPM2 is a Ca(2+)-permeable non-selective cation channel, the activity of which is regulated by intracellular and extracellular Ca(2+). A unique feature of TRPM2 is its activation by ADP-ribose and chemical species that arise during oxidative stress, for example, NAD(+) and H(2)O(2).
K, Hill +3 more
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Divalent Copper Is a Potent Extracellular Blocker for TRPM2 Channel
Biochemical and Biophysical Research Communications, 2012Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cationic channel in the TRP channel family. The channel activity can be regulated by reactive oxygen species (ROS) and cellular acidification, which has been implicated to the pathogenesis of diabetes and some neuronal disorders.
Shang-Zhong Xu
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TRPM2 channel properties, functions and therapeutic potentials
Expert Opinion on Therapeutic Targets, 2010Oxidative stress, through production of reactive oxygen species, triggers disturbance in intracellular calcium [Ca(2+)](i) homeostasis, which has been identified as an important causative factor in the pathogenesis of numerous inflammatory, cardiovascular and neurodegenerative diseases.Transient receptor potential melastatin 2 (TRPM2) protein forms a ...
Lin-Hua, Jiang +3 more
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The Juvenile Myoclonic Epilepsy-Related Protein EFHC1 Interacts With the Redox-Sensitive TRPM2 Channel Linked to Cell Death [PDF]
Cell Calcium, 2012 The transient receptor potential M2 channel (TRPM2) is the Ca(2+)-permeable cation channel controlled by cellular redox status via β-NAD(+) and ADP-ribose (ADPR).
Kazuhiro Yamakawa +2 more
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TRPM2 Channel Regulates Endothelial Barrier Function
2009Oxidative [Au1]stress, through the production of oxygen metabolites such as hydrogen peroxide[Au2] (H(2)O(2)), increases vascular endothelial permeability and plays a crucial role in several lung diseases. The transient receptor potential (melastatin) 2 (TRPM2) is an oxidant-sensitive, nonselective cation channel that is widely expressed in mammalian ...
Claudie M, Hecquet +2 more
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