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Architecture of the human TRPM2 channel
Science, 2018Structural Biology Adenosine diphosphate–ribose (ADPR) mediates calcium (Ca2+) release by activating the transient receptor potential melastatin 2 (TRPM2) channel. Three structures now elucidate the conformational regulation mechanism of TRPM2 gating. Wang et al.
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Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole
Naunyn-Schmiedeberg's Archives of Pharmacology, 2004TRPM2 is a Ca(2+)-permeable non-selective cation channel that uniquely is activated by intracellular ADP-ribose. To date, only one pharmacological blocker of this channel, namely flufenamic acid (FFA), has been described. Here we demonstrate, using patch clamp electrophysiology, that the antifungal imidazoles clotrimazole and econazole inhibit ADP ...
K, Hill, S, McNulty, A D, Randall
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Nociceptive Roles of TRPM2 Ion Channel in Pathologic Pain
Molecular Neurobiology, 2018Pain is a protective mechanism that enables us to avoid potentially harmful environments. However, when pathologically persisted and aggravated under severely injured or inflamed conditions, pain often reduces the quality of life and thus is considered as a disease to eliminate.
Yongwoo Jang +3 more
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Regulation of TRP channel TRPM2 by the tyrosine phosphatase PTPL1
American Journal of Physiology-Cell Physiology, 2007TRPM2, a member of the transient receptor potential (TRP) superfamily, is a Ca2+-permeable channel, which mediates susceptibility to cell death following activation by oxidative stress, TNFα, or β-amyloid peptide. We determined that TRPM2 is rapidly tyrosine phosphorylated after stimulation with H2O2 or TNFα.
Wenyi, Zhang +5 more
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Potential functions of TRPM2 and TRPM7 channels in the tumor microenvironment
Journal of Leukocyte BiologyAbstract The tumor microenvironment (TME) is a complex and dynamic ecosystem consisting of both cellular and non-cellular components that collectively modulate the antitumor immune response, as well as cancer growth, invasion, metastasis, immune evasion, and resistance to therapy.
Irma Yadira Izaguirre-Hernández +1 more
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Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels
Progress in Biophysics and Molecular Biology, 2010The ability to sense and adapt to a wide variety of environmental changes is crucial for the survival of all cells. Transient receptor potential (TRP) channels play pivotal roles in these sensing and adaptation reactions. In vertebrates, there are about 30 TRP channels; these are divided into six subfamilies by homology of the protein sequences.
Yamamoto, Shinichiro +2 more
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The molecular nature of temperature dependence of the TRPM2 channel
Biophysical Journal, 2022Adam Bartok, Laszlo Csanady
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Structural and Functional Basis of the Selectivity Filter as a Gate in Human TRPM2 Channel
Cell Reports, 2021Xiaokang Zhang +2 more
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Architecture of the TRPM2 Channel and Its Activation Mechanism by ADP-Ribose and Calcium
Nature, 2018Wei Lü, Weinan Sun, Juan Du
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