Results 161 to 170 of about 3,697 (189)
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Discovery and characterization of novel TRPML1 agonists
Bioorganic and Medicinal Chemistry LettersScreening a library of >100,000 compounds identified the substituted tetrazole compound 1 as a selective TRPML1 agonist. Both enantiomers of compound 1 were separated and profiled in vitro and in vivo. Their selectivity, ready availability and CNS penetration should enable them to serve as the tool compounds of choice in future TRPML1 channel ...
Duane Burnett +2 more
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TRPML1 and TFEB, an Intimate Affair
2022Ca2+ is a universal second messenger that plays a wide variety of fundamental roles in cellular physiology. Thus, to warrant selective responses and to allow rapid mobilization upon specific stimuli, Ca2+ is accumulated in organelles to keep it at very low levels in the cytoplasm during resting conditions.
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TRPML1: An Ion Channel in the Lysosome
2014The first member of the mammalian mucolipin TRP channel subfamily (TRPML1) is a cation-permeable channel that is predominantly localized on the membranes of late endosomes and lysosomes (LELs) in all mammalian cell types. In response to the regulatory changes of LEL-specific phosphoinositides or other cellular cues, TRPML1 may mediate the release of Ca(
Wuyang, Wang +3 more
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Lysosomal TRPML1 Channel: Implications in Cardiovascular and Kidney Diseases
2021Lysosomal ion channels mediate ion flux from lysosomes and regulate membrane potential across the lysosomal membrane, which are essential for lysosome biogenesis, nutrient sensing, lysosome trafficking, lysosome enzyme activity, and cell membrane repair.
Guangbi, Li, Pin-Lan, Li
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TRPML1-induced autophagy inhibition triggers mitochondrial mediated apoptosis
Cancer Letters, 2022Previous studies have demonstrated that autophagy tightly regulates apoptosis. However, the underlying mechanism whereby autophagy regulates apoptosis remains unclear. Here, we discover a "autophagy inhibition-mitochondrial turnover disruption-ROS elevation-DNA damage-p53 transactivation-apoptosis" axis that explicates the process of autophagy ...
Yucheng Liu +8 more
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TRPML1-/TFEB-Dependent Regulation of Lysosomal Exocytosis
2019Emerging experimental evidences indicate that the lysosome can trigger a calcium signaling, via TRPML1/calcineurin/TFEB pathway, that promotes lysosomal exocytosis and clearance of lysosomal accumulation in various cellular models of lysosomal storage disorders (LSDs).
Di Paola, Simone, Medina, DL
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MCOLN1/TRPML1 in the lysosome: a promising target for autophagy modulation in diverse diseases
AutophagyMCOLN1/TRPML1 is a nonselective cationic channel specifically localized to the late endosome and lysosome. With its property of mediating the release of several divalent cations such as Ca2+, Zn2+ and Fe2+ from the lysosome to the cytosol, MCOLN1 plays a pivotal role in regulating a variety of cellular events including endocytosis, exocytosis ...
Jiansong Qi +11 more
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Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin
Proceedings of the National Academy of Sciences of the United States of America, 2022Ninghai Gan, Yan Han, Youxing Jiang
exaly
The Regulation of Lysosomal TRPML1 Channel on Insulin Secretion
SSRN Electronic Journal, 2022Wei Su +4 more
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