Results 201 to 210 of about 26,834 (239)
A transient receptor potential vanilloid 1-dependent corneal-trigeminal neuroinflammatory circuit promotes corneal neuropathy. [PDF]
Exp Mol MedPizzano M +10 more
europepmc +1 more source
Vitamin D3 mediates amelioration of ulcerative colitis via the TRPV1-MAPK signaling pathway. [PDF]
Front ImmunolZhao K +5 more
europepmc +1 more source
Hormonal Dysregulation and Neuroinflammation in Endometriosis: Convergent Druggable Pathways. [PDF]
Curr Issues Mol BiolOlteanu IL +3 more
europepmc +1 more source
TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors
Cell Reports, 2022 The molecular mechanism underlying the functional interaction between H1R and TRPV1 remains unclear. We show here that H1R directly binds to the carboxy-terminal region of TRPV1 at residues 715-725 and 736-749. Cell-penetrating peptides containing these sequences suppress histamine-induced scratching behavior in a cheek injection model.
Weiji Weng, Yingping Wang, Aiwu Zhou
exaly +4 more sources
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2014
TRPV1 is a well-characterised channel expressed by a subset of peripheral sensory neurons involved in pain sensation and also at a number of other neuronal and non-neuronal sites in the mammalian body. Functionally, TRPV1 acts as a sensor for noxious heat (greater than ~42 °C). It can also be activated by some endogenous lipid-derived molecules, acidic
Bevan, Stuart +2 more
openaire +5 more sources
TRPV1 is a well-characterised channel expressed by a subset of peripheral sensory neurons involved in pain sensation and also at a number of other neuronal and non-neuronal sites in the mammalian body. Functionally, TRPV1 acts as a sensor for noxious heat (greater than ~42 °C). It can also be activated by some endogenous lipid-derived molecules, acidic
Bevan, Stuart +2 more
openaire +5 more sources
2021
Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that is intensively expressed in the peripheral nerve system and involved in a variety of physiological and pathophysiological processes in mammals. Its activity is of great significance in transmitting pain or itch signals from peripheral sensory neurons to the ...
Fengxian, Li, Fang, Wang
openaire +2 more sources
Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that is intensively expressed in the peripheral nerve system and involved in a variety of physiological and pathophysiological processes in mammals. Its activity is of great significance in transmitting pain or itch signals from peripheral sensory neurons to the ...
Fengxian, Li, Fang, Wang
openaire +2 more sources
Anandamide and vanilloid TRPV1 receptors [PDF]
British Journal of Pharmacology, 2003 A large body of evidence now exists to substantiate that the endocannabinoid, anandamide, activates TRPV1 receptors. It is a low intrinsic efficacy TRPV1 agonist that behaves as a partial agonist in tissues with a low receptor reserve, while in tissues with high receptor reserve and in circumstances associated with certain disease states, it behaves as
Ruth A Ross
exaly +3 more sources
TRPV1 and Synaptic Transmission
Current Pharmaceutical Biotechnology, 2011Transient Receptor Potential Vanilloid Type 1 is a prominent "pain" receptor expressed in sensory afferent neurons. TRPV1 on peripheral nerve terminals detects a variety of noxious stimuli generated at sites of injury and inflammation, and in turn, drives the excitation and sensitization of C-fibers neurons.
Jose A, Matta, Gerard P, Ahern
openaire +2 more sources